Results 141 to 150 of about 1,147,749 (362)

Long-term survival outcomes of neoadjuvant chemotherapy in stage II-III HR+/HER2- breast cancer

open access: yesScientific Reports
Breast cancer is the most common malignant tumor among women worldwide. Hormone receptor-positive/HER2-negative (HR+/HER2-) breast cancer is the largest subgroup among these cases.
Jiaxing Liu   +11 more
doaj   +1 more source

Assessment of Various Insulin Resistance Surrogate Indices in Thai People with Type 2 Diabetes Mellitus

open access: yesJournal of the ASEAN Federation of Endocrine Societies
Objective. To compare insulin surrogate indices with the homeostasis model assessment of insulin resistance (HOMA-IR) in Thai people with type 2 diabetes (T2D). Methodology.
Waralee Chatchomchuan   +5 more
doaj   +1 more source

Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
Metabolic rewiring in cancer is mapped across glucose, amino acid, lipid, nucleotide, and mitochondrial pathways, with emphasis on immune regulation. The review integrates mechanisms linking these pathways to tumor progression and therapy resistance, and profiles nanomaterial platforms that both deliver therapeutics and actively reprogram ...
Xiaosu Zhou   +7 more
wiley   +1 more source

GLM7 – A Novel Composite Glycolipid Index Derived from Routine Health Indicators for Enhanced Diagnosis and Prediction of Multimorbidity

open access: yesAdvanced Science, EarlyView.
This study leverages NHANES data to analyze 49 routine indicators, identifying the top 10 diagnostic markers for five major diseases and introducing GLM7, a novel indicator. Restricted cubic spline analyses, forest plot evaluations, and XGBoost modeling demonstrate conventional indicators' efficacy and GLM7's value for disease diagnosis/prediction ...
Zhihua Wang   +8 more
wiley   +1 more source

PDGFRα+DPP4+ Fibroblasts‐Macrophage Crosstalk Induces Orbital Fibrosis in Treatment‐Resistant Thyroid Eye Disease via the GAS6‐AXL Pathway

open access: yesAdvanced Science, EarlyView.
This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng   +14 more
wiley   +1 more source

The role of epigenetic methylations in thyroid Cancer

open access: yesWorld Journal of Surgical Oncology
Thyroid cancer (TC) represents one of the most prevalent endocrine malignancies, with a rising incidence worldwide. Epigenetic alterations, which modify gene expression without altering the underlying DNA sequence, have garnered significant attention in ...
Xiaojie Yu   +8 more
doaj   +1 more source

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