Results 271 to 280 of about 1,147,749 (362)

Serum Lipidome and Metabolome Alterations in Obese Patients Undergoing Targeted Diet and Exercise Interventions: A Marker of Thyroid Function Recovery? [PDF]

Int J Endocrinol
Zhou C, Wang H, Yu Q, Xin J, Chen H, Zhang R, Guan Q, Shao S.   +7 more
europepmc   +1 more source

Molecular Docking and Target‐Specific Binding Profiles of Benzosuberane‐Based Compounds

ChemMedChem, EarlyView.
Benzosuberane represents a promising scaffold in medicinal chemistry. Several benzosuberane‐based derivatives are described in this review as anticancer agents, including antivascular agents, DNA‐intercalators, receptor modulators and kinase inhibitors.
Michail A. Saragatsis, Gemma K. Kinsella, James F. Curtin, Tao Zhang   +3 more
wiley   +1 more source

Interaction Between Thyroid Hormones and Bone Morphogenetic Proteins in the Regulation of Steroidogenesis by Granulosa Cells. [PDF]

Int J Mol Sci
Motohashi K, Soejima Y, Yamamoto K, Iwata N, Suyama A, Nakano Y, Otsuka F.   +6 more
europepmc   +1 more source

Hallmarks of Neuroblastoma—Pathophysiology, Diagnosis, and Therapeutic Interventions

Cancer Nexus, EarlyView.
ABSTRACT Neuroblastoma, the most common extracranial solid tumor in childhood, continues to challenge clinicians and researchers because of its heterogeneous nature and complex pathophysiology. Recent breakthroughs in molecular profiling revealed intricate genetic alterations driving tumor progression, necessitating an updated perspective on the ...
Abhimanyu Thakur, Anne Dijkstra
wiley   +1 more source

The association between early-life famine exposure and adulthood risk of thyroid diseases. [PDF]

Front Nutr
Liu L, Yu L, Zheng D, Zhang D, Liu L, Wan L, Shen Y, Cheng H.   +7 more
europepmc   +1 more source

Is Aortic Balloon Occlusion Effective to Reduce Blood Loss During Lower Lumbar Tumor Resection?

Cancer Nexus, EarlyView.
ABSTRACT Purpose In this study, we evaluated the efficacy and safety of using an aortic balloon to control blood loss during lower lumbar tumor resection. Methods We retrospectively reviewed 82 patients with tumors involving the lower lumbar spine (L4, L5, or Both), who were treated at our center from July 2015 to September 2023.
Jiacheng Chen, Xiaodong Tang, Wei Guo, Rongli Yang, Dasen Li, Huayi Qu, Shun Tang, Jie Zang   +7 more
wiley   +1 more source

Different Risk Factors for Lymph Node Metastasis in Papillary Thyroid Carcinoma Patients with and without Hashimoto's Thyroiditis. [PDF]

Int J Gen Med
Chen J, Zhong H, Wang Y.
europepmc   +1 more source

A multipart phase 1 study of the safety, pharmacodynamics and pharmacokinetics of ALG‐055009, a novel thyroid hormone receptor beta (THR‐β) agonist for metabolic dysfunction‐associated steatohepatitis (MASH), in healthy participants

Clinical Pharmacology in Drug Development, EarlyView.
Abstract ALG–055009 is an oral thyroid hormone receptor beta (THR‐β) agonist being evaluated for treating metabolic dysfunction–associated steatohepatitis (MASH). This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of ALG‐055009 and bioavailability/food effect.
Hakim Charfi, Benedetta Massetto, Megan Fitzgerald, Kha Le, Stanley Wang, Ifong Kan‐Eng, Meenakshi Venkatraman, Naqvi Mohammad, Lawrence Blatt, Tse‐I Lin, Sushmita M. Chanda, John Fry   +11 more
wiley   +1 more source

Risk factors for postoperative recurrence of differentiated thyroid cancer: a retrospective study. [PDF]

Sci Rep
Han S, Yang Y, Yimaer W, Abudureheman D, Wang H.   +4 more
europepmc   +1 more source

Impact of Antihypertensive Treatment on Outcomes of Adjuvant Bevacizumab for Ovarian Cancer (IATRO), Results from a Nationwide Emulated Clinical Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Antiangiogenic therapy with bevacizumab improves outcomes in ovarian cancer but induces hypertension, leading to major adverse cardiovascular events (MACE). While calcium channel blockers (CCBs) and angiotensin‐converting enzyme inhibitors (ACEi) are recommended for managing bevacizumab‐associated hypertension, their impacts on cancer progression and ...
Floriane Jochum, Élise Dumas, Joe‐Elie Salem, Stéphane Ederhy, Anne‐Sophie Hamy, Lise Lecointre, Enora Laas, Fabien Reyal, Fabrice Lecuru, Cherif Akladios, Paul Gougis   +10 more
wiley   +1 more source