Results 61 to 70 of about 295,040 (235)

Cancer of Thyroid [PDF]

The Journal of Nervous and Mental Disease, 1919
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openaire   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

QPRT: a potential marker for follicular thyroid carcinoma including minimal invasive variant : a gene expression, RNA and immunohistochemical study

, 2009
Background The differential diagnosis between follicular thyroid adenoma and minimal invasive follicular thyroid carcinoma is often difficult for several reasons.
Hansmann Martin-Leo, Vorländer Christian, Frank, Matthias, Döring Claudia, Hinsch, Nora, Frank Matthias, Döring, Claudia, Hansmann, Martin-Leo, Hinsch Nora, Vorländer, Christian   +9 more
core   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

USP25 attenuates the immunosuppressive tumor microenvironment via the deubiquitination of TAB2 in head and neck squamous cell carcinoma

Cell Death Discovery
The role of deubiquitinating enzymes in the tumor immune microenvironment (TIME) remains understudied. Here, we sought to identify the mechanisms of USP25 modulation in the TIME of head and neck squamous cell carcinoma (HNSCC).
Xingchen Li, Yidi Jia, Runfang Zhang, Xu Zheng, Chuang Li, Weike Ma, Yang Han, Chen Zheng, Yanqing Li, Qianqian Shi, Hu Hei, Songtao Zhang, Jianwu Qin   +12 more
doaj   +1 more source

Acoustic radiation force impulse imaging for differentiation of thyroid nodules

, 2012
Background: Acoustic Radiation Force Impulse (ARFI)-imaging is an ultrasound-based elastography method enabling quantitative measurement of tissue stiffness.
Stefan Zeuzem, Lisa Voelkl (139194), Holzer, Katharina, Katharina Holzer (139190), Schroeter, Hartmut, Friedrich-Rust, Mireen, Dauth, Nina, Christian Berner, Katharina Holzer, Joerg Bojunga, Gesine Meyer (139188), Hartmut Schroeter (139199), Joerg Bojunga (139182), Berner, Christian, Meyer, Gesine, Lisa Voelkl, Herrmann, Eva, Nina Dauth (139184), Hartmut Schroeter, Voelkl, Lisa, Nina Dauth, Mireen Friedrich-Rust, Bojunga, Jörg, Eva Herrmann (139197), Gesine Meyer, Christian Berner (139186), Eva Herrmann, Mireen Friedrich-Rust (139200), Zeuzem, Stefan, Stefan Zeuzem (22856)   +29 more
core   +1 more source

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
wiley   +1 more source

DNA topoisomerases participate in fragility of the oncogene RET [PDF]

, 2013
Fragile site breakage was previously shown to result in rearrangement of the RET oncogene, resembling the rearrangements found in thyroid cancer. Common fragile sites are specific regions of the genome with a high susceptibility to DNA breakage under ...
Yuh-Hwa Wang (457429), Dillon, LW, Yuh-Hwa Wang, Christine E. Lehman (457427), Laura W Dillon, Dillon Laura W., Nikiforov Yuri E., Pierce Levi C. T., Wang, YH, Laura W. Dillon (457426), Lehman, Christine E., Christine E Lehman, Lehman, CE, Pierce, Levi C. T., Nikiforov, Yuri E., Pierce, LCT, Yuri E. Nikiforov (457428), Levi C T Pierce, Rybenkov, Valentin V, Wang, Yuh-Hwa, Wang Yuh-Hwa, Levi C. T. Pierce (454414), Lehman Christine E., Yuri E Nikiforov, Dillon, Laura W., Nikiforov, YE   +25 more
core   +1 more source

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

Optimizing surgical outcomes in papillary thyroid carcinoma with Hashimoto’s Thyroiditis: a retrospective comparative study of unilateral and total thyroidectomy

Scientific Reports
The management of papillary thyroid carcinoma (PTC) concurrent with Hashimoto’s thyroiditis (HT) lacks standardized guidelines, especially concerning surgical strategies. This study aimed to compare unilateral thyroidectomy (UT) with total thyroidectomy (
Xiaoyong Wen, Shiwei Zhou, Wu Li, Hui Li, Xiaohua Song, Yu Mao, Zeyu Li, Guangji Chen, Xiaowei Peng, Peng Wu   +9 more
doaj   +1 more source