Results 51 to 60 of about 7,032 (221)

PDGFRα+DPP4+ Fibroblasts‐Macrophage Crosstalk Induces Orbital Fibrosis in Treatment‐Resistant Thyroid Eye Disease via the GAS6‐AXL Pathway

Advanced Science, Volume 12, Issue 45, December 4, 2025.
This study elucidates macrophage‐induced orbital fibrosis in TED via the GAS6‐AXL pathway, a treatment‐resistant disorder lacking non‐surgical therapies. Using a novel patient cell‐derived orthotopic animal model of orbital fibrosis for TED, we repurpose an existing fibrosis therapy, addressing the absence of stable models and offering a potential ...
Lu Cheng, Jinwei Cheng, Guiling Liang, Xiaorui Wang, Yanwen Ge, Jiapei Liu, Luwei Cai, Hui Ying, Fenfen Wang, Jing Hu, Yufan Wang, Philipp E. Scherer, Ben Zhou, Mengle Shao, Fang Zhang   +14 more
wiley   +1 more source

Incidental Finding of Thyroid Tuberculosis by Operation for Graves’ Disease: A Rare Case Presentation

Case Reports in Endocrinology
Thyroid tuberculosis is a rare form of extrapulmonary tuberculosis, even in endemic countries such as Morocco; its precise incidence is not well-defined. The clinical presentation of thyroid tuberculosis can vary, often being asymptomatic.
Zineb El Azime, Samira Handa, Ghita Bourkadi, Hayat Aynaou, Houda Salhi, Hanan El Ouahabi   +5 more
doaj   +1 more source

Results of diplopia and strabismus in patients with severe thyroid ophthalmopathy after orbital decompression

Indian Journal of Ophthalmology, 2014
Purpose: It has been frequently stated that the orbital decompression, in patients with thyroid ophthalmopathy, does not usually improve extraocular muscles function and that after the operation there is often a deterioration of these functions.
Radmilo Roncevic, Zorica Savkovic, Dusan Roncevic   +2 more
doaj   +1 more source

Selenium improves mild Graves’Orbitopathy: a randomized, double-blind, placebo-controlled study. [PDF]

, 2011
Background Free oxygen radicals and cytokines play a pathogenic role in Graves’ orbitopathy (GO). This study reports the results of a randomized, double-blind, placebo-controlled trial on the effect of selenium, an antioxidant agent, or pentoxifylline ...
ALTEA, MARIA ANTONIETTA
core  

Erdheim-Chester Disease: a comprehensive review of the literature [PDF]

, 2013
Erdheim-Chester Disease (ECD) is a rare form of non Langerhans' cell histiocytosis. Individuals affected by this disease are typically adults between their 5th and 7th decades of life. Males and females are almost equally affected.
Mirra Manevich-Mazor, Roei D Mazor, Yehuda Shoenfeld   +2 more
core   +1 more source

Hyperthyroid Hypokalemic Periodic Paralysis in a Nepali Male; A Case Report

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Hyperthyroid Hypokalemic Periodic Paralysis (HHPP), marked by acute weakness and hypokalemia. Prompt potassium replacement and hyperthyroidism management are essential to prevent life‐threatening outcomes. This case highlights its presentation in a Nepali male, reinforcing the need for high clinical suspicion.
Ashish Tamang, Prakash Sapkota, Sankalpa Humagain, Kemisha Dhakal, Chhavi Sachdeva, Deshant Shah, Prakriti Lamsal   +6 more
wiley   +1 more source

Clinical characteristics of moderate-to-severe thyroid associated ophthalmopathy in 354 Chinese cases.

PLoS ONE, 2017
Thyroid associated ophthalmopathy (TAO) is an autoimmune inflammatory disorder which disfigures appearance, threatens vision, and results in a pronounced loss of quality of life. The diversity and ethnic difference of the disease manifestations have made
Qian Li, Huijing Ye, Yungang Ding, Guo Chen, Zhichang Liu, Jianan Xu, Rongxin Chen, Huasheng Yang   +7 more
doaj   +1 more source

Does thyroid surgery for Graves' disease improve health-related quality of life? [PDF]

, 2012
PURPOSE: Graves' disease can induce alterations of the psychosocial well-being that negatively influence the overall well-being of patients. Among the current treatments, surgery has limited indications, and its impact on the health-related quality of ...
AMODIO, Emanuele, BONVENTRE, Sebastiano, DI PAOLA, Valentina, GULOTTA, Gaspare, MORFINO, Giuditta, PALADINO, Nunzia Cinzia, Scerrino,G   +6 more
core   +1 more source

Worth the Effort: Lessons for Discovery and Care From an Unusual Case of Gorlin Syndrome

American Journal of Medical Genetics Part A, Volume 197, Issue 9, September 2025.
ABSTRACT Gorlin‐Goltz Syndrome (GGS) is a rare autosomal dominant genetic disorder encompassing a diverse range of clinical manifestations, including congenital anomalies and predisposition to cancer. Pathogenic variants in PTCH1 and SUFU account for up to 79% and 6% of cases, respectively. Currently, an estimated 15%–27% of individuals with a clinical
V. Taliercio, J. Zhao, S. E. Boyden, R. Mao, P. Bayrak‐Toydemir, A. Pflaum, J. Palumbos, A. Andrews, E. E. Baldwin, C. Welt, Mackenzie Fait, Undiagnosed Diseases Network, L. D. Botto, D. Viskochil   +13 more
wiley   +1 more source

What are the psychosocial outcomes of treatment for thyroid eye disease? A systematic review [PDF]

, 2014
Background: Thyroid eye disease (TED) causes a number of esthetic and visual problems and its treatment requires close clinical assessment, often for several years.
Bahmani-Kashkouli M, Boboridis KG, Daniel G. Ezra, Geoffrey E. Rose, Hayley B. McBain, Kulig G, Nasr E, Rajendram R, Sadie Wickwar, Shashivadan P. Hirani, Stanton P. Newman, Yeatts RP   +11 more
core   +1 more source