Results 91 to 100 of about 350,385 (360)

Research progress in effects of exposure to polycyclic aromatic hydrocarbons on thyroid function: a review

Zhongguo gonggong weisheng
Currently, the incidence of thyroid diseases is high around the world and that of thyroid cancer is increasing year by year. Thus, there is an urgent need to take preventive measures.
Bin ZHOU, Qiang ZENG, Pingxia XIANG, Ting YAO, Rui HU, Jinjun LUO   +5 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

Study of clinical profile of thyroid functions in patients of type 2 diabetes mellitus

, 2021
Jinaga Satyanarayan Rao
openalex   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

In Vivo Anabolic Androgenic Steroid Alters Thyroid Gland Functions in Female Rats

, 2022
Ali Abdulhussein, Shihab Hattab Mutlag, Mahmood Kahtan, Elaf Dawood, Nasrollah Shahidi, Andrew Parkinson, Nick Evans, Rodrigo Fortunato, A Fragkaki, Michael Bahrke, Charles Yesalis, Shehzad Basaria, Justin Wahlstrom, Adrian Dobs, A Meikle, B Dirlikov, S Lavoie, K Shem, M Alen, P Rahkila, M Reinil, R Vihko, Asma Aljaberi, Hessa Md, Boharoon, Md   +25 more
openalex   +2 more sources

The role of primary cilia in thyroid diseases

Frontiers in Endocrinology
Primary cilia (PC) are non-motile and microtube-based organelles protruding from the surface of almost all thyroid follicle cells. They maintain homeostasis in thyrocytes and loss of PC can result in diverse thyroid diseases. The dysfunction of structure
Zijiao Tian, Xinlin Li, Xue Yu, Shuxin Yan, Jingwei Sun, Wenxin Ma, Xiaoyun Zhu, Yang Tang   +7 more
doaj   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Cytological study of different thyroid lesions and its correlation with thyroid function test [PDF]

, 2023
Ruchi Yadav, Shaila Mitra, Rajesh Rai
openalex   +1 more source

Therapeutic strategies to target the receptor tyrosine kinase AXL in thyroid cancer

, 2012
The AXL receptor tyrosine kinase is overexpressed and active in various cancer types including thyroid carcinoma, and several preclinical studies suggest that targeting AXL is an effective therapeutical strategy in AXL-positive cancers.
MELILLO, ROSA MARINA, GnanaPrakasam Krisnamoorthy, VISCIANO, CARLA, CARLOMAGNO, Francesca, LIOTTI, FEDERICA, GUIDA, TERESA   +5 more
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