Results 161 to 170 of about 11,357,056 (401)

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Prevalence of Thyroid Function Abnormalities and Its Association with Physical Fatigue in First-Year Medical Students

International Journal of Integrated Health Sciences
Objective: To estimate prevalence and type of thyroid function abnormalities and explore their associations with physical fatigue in first-year medical students.
Arindam Ghosh, Debdeep Dasgupta, Susumna Biswas   +2 more
doaj   +1 more source

Evaluation of the structure, autoimmunity, and functions of the thyroid gland in familial Mediterranean fever patients

, 2020
Müge Özsan Yılmaz, Muhammet Murat Çelik, Fatma Öztürk Keleş, Oğuzhan Özcan   +3 more
openalex   +1 more source

AI‐Guided SERS Defines a Pan‐Cancer Diagnostic Biomarker

Advanced Science, EarlyView.
An AI‐enabled SERS platform integrates automated exosome enrichment with molecular fingerprinting to enable accurate early detection and differential diagnosis of ten common cancers. The system identifies exosomal dATP as a universal Raman biomarker, offering a scalable, noninvasive, and clinically translatable approach for precision oncology ...
Cai Zhang, Wen‐Hui Zhao, Duo Zuo, Tianxing Zhou, Wenjing Hou, Lingwei Wang, Shangheng Shi, Yang Yang, Yuanyuan Liu, Shao‐Kai Sun, Li Ren, Zhaoxiang Ye, Dingbin Liu, Dong Li, Xiaoyuan Chen, Jihui Hao   +15 more
wiley   +1 more source

Polychlorinated naphthalenes in the serum of individuals with thyroid dysfunction and their potential mechanisms of impact on disease progression

Emerging Contaminants
Polychlorinated naphthalenes (PCNs) comprise 75 congeners, with varying concentrations and major congeners across different populations. Recent studies have found a relationship between PCNs and thyroid hormone levels, suggesting they may interfere with ...
Yuhao Fan, Dan Chen, Xinyu Lou, Ye Wu, Jie Sun, Zhiyan Liu, Jun Jin, Tan Chen   +7 more
doaj   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Altered thyroid function in severely injured patients

, 2012
Elena Grill, Michelle Strong, Seema S. Sonnad, Babak Sarani, José L. Pascual, Heather W. Collins, Carrie A. Sims   +6 more
openalex   +2 more sources

THYROID FUNCTION AND MENTAL HEALTH IN CHILDBEARING AGE WOMEN

, 2021
Suryati Kumorowulan, Yusi Dwi Nurcahyani, Leny Latifah, Diah Yunitawati   +3 more
openalex   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source