Results 91 to 100 of about 148,119 (303)

Laboratory evaluation of thyroid function: Dilemmas and pitfalls

Medical Journal of Dr. D.Y. Patil University, 2016
Among all endocrine disorders, thyroid dysfunction is possibly most common endocrine disorder barring obesity. This implies that thyroid function tests (TFT) are routinely ordered for laboratory test for its evaluation.
M K Garg, Namita Mahalle, K.V. S. Hari Kumar   +2 more
doaj   +1 more source

Thyroid Function Tests in Preeclampsia

, 2018
Background: The thyroid hormones are protein-bound in the serum, and only 0.02% of T4 and 0.2% of T3 are free, biologically active hormones. 45–70% of thyroid hormones are bound to thyroxine-binding globulin (TBG), and the rest to transthyretin and ...
Shaugfta Aara, Sumaira Chowdhary, Masarat Nazeer, Musadiq Allaqband   +3 more
core   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Prevalence of Thyroid Function Abnormalities and Its Association with Physical Fatigue in First-Year Medical Students

International Journal of Integrated Health Sciences
Objective: To estimate prevalence and type of thyroid function abnormalities and explore their associations with physical fatigue in first-year medical students.
Arindam Ghosh, Debdeep Dasgupta, Susumna Biswas   +2 more
doaj   +1 more source

Novel associations for hypothyroidism include known autoimmune risk loci

, 2011
Hypothyroidism is the most common thyroid disorder, affecting about 5% of the general population. Here we present the first large genome-wide association study of hypothyroidism, in 2,564 cases and 24,448 controls from the customer base of 23andMe, Inc.,
Amy K. Kiefer (160836), David A. Hinds (128908), Eriksson Nicholas, Kiefer Amy K., Joanna L. Mountain (173244), Joyce Y. Tung (160861), Francke Uta, Chuong B. Do, Nicholas Eriksson (54415), Uta Francke (41540), Hinds David A., David A Hinds, Tung Joyce Y., Joyce Y Tung, Nicholas Eriksson, Amy K Kiefer, Joanna L Mountain, Chuong B. Do (22097), Mountain Joanna L., Joanna L. Mountain, Do Chuong B., Uta Francke, Joyce Y. Tung, Chuong B Do, Amy K. Kiefer, David A. Hinds   +25 more
core   +1 more source

Dual‐Physical‐Field Nanocatalysis: Injectable Hydrogel Enables Piezo‐Photothermal Synergy for Breast Cancer Therapy

Advanced Science, EarlyView.
ABSTRACT Piezocatalytic therapy (PCT) harnesses mechanical energy to generate tumor‐lethal reactive oxygen species (ROS), but its efficacy is limited by rapid electron‐hole recombination and poor intratumoral retention. To overcome these limitations, we engineered heterostructured BiOCl@CuO nanosheets embedded in an injectable, conductive ...
Can Tian, Shihan Xiao, Xuan Chen, Danni Zhang, Zizhen Liu, Jing Wang, Ning Xie, Wei Li   +7 more
wiley   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

Early prediction of transient versus permanent congenital hypothyroidism: a retrospective cohort study [PDF]

Annals of Pediatric Endocrinology & Metabolism
Purpose Early differentiation between transient congenital hypothyroidism (TCH) and permanent congenital hypothyroidism (PCH) is crucial for optimizing the duration of treatment.
Myung Ji Yoo, Ji-Eun Lee, Eun Young Joo, Jisun Park, Young Ju Suh, Su Jin Kim   +5 more
doaj   +1 more source

Exploring reasons for variation in ordering thyroid function tests in primary care: a qualitative study

, 2014
Background: The ordering of thyroid function tests (TFTs) is increasing but there is not a similar increase in thyroid disorders in the general population, leading some to query whether inappropriate testing is taking place.
Child, S, Hamilton, W, Fleming, S., Hardwick, R., Vaidya, Bijay, Patterson, A, Tomlinson, J., Hardwick, RJL, Zhelev, Z., Tomlinson, J, Zhelev, Z, Hamilton, W. T., Heaton, J, Fleming, S, Hyde, C, Vaidya, B, Griffiths, G, Griffiths, G., Child, S., Patterson, A., Hyde, C., Heaton, J.   +21 more
core  

Results of Thyroid Function Tests in Premature Infants

, 2016
Introduction: To determine the rate, etiology and morbidity association of disorders of thyroid function tests (TFTs) in premature babies.Materials and Methods: A total of 139 premature babies who were admitted to Uludag University Faculty of Medicine ...
Onur Bağcı, Doğan, Pelin, Cansu Canbolat, Eren, Erdal, Sağlam, Halil, Erdal Eren, Varal, İpek Güney, Pelin Doğan, Hilal Özkan, Canbolat, Cansu, İpek Güney Varal, Nilgün Köksal, Köksal, Nilgün, Özkan, Hilal, Halil Sağlam, Bağcı, Onur   +15 more
core   +1 more source