Results 51 to 60 of about 209,512 (264)

Gelsolin (GSN) as a key regulator in estrogen receptor-positive breast cancer: implications for prognosis, chemotherapy sensitivity, and immune infiltration

Discover Oncology
Background Gelsolin (GSN), a cytoskeletal regulatory protein implicated in cancer progression, remains understudied in estrogen receptor-positive breast cancer (ER + BC), particularly regarding its links to immune infiltration and drug resistance ...
Mian Lv, Huiling Wang, Guanqing Feng, Qingxiao Nong, Shouwen Tao, Yanfei Ma, Dalang Fang   +6 more
doaj   +1 more source

Single‐Cell Reveal GALNT7‐Dependent Ferroptosis Suppression as a Mechanism of Immunotherapy Resistance in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Integrated clinical and mechanistic analyses identify GALNT7 as a ferroptosis‐suppressive regulator associated with immunotherapy resistance in non‐small cell lung cancer. GALNT7 depletion promotes lipid peroxidation, mitochondrial dysfunction, and ferroptosis, enhances CD8+ T‐cell activation and IFN‐γ production, and sensitizes tumors to PD‐1 blockade,
Jiadi Gan, Qian Zheng, Deng Liu, Ruichao Nie, Menglin Yao, Xiaolong Tang, Renjie Xu, Jinghong Xian, Wenjun Meng, Wenxin Luo, Dan Liu, Guiyi Ji   +11 more
wiley   +1 more source

Thyroid Gland in Patients with Rheumatoid Arthritis

Клиническая и экспериментальная тиреоидология, 2009
The purpose of our study was to investigate the main parameters of thyroid status in patients with rheumatoid arthritis (RA), as well as particularities of course of this disease depending on of thyroid gland function disorder. Materials and methods.

doaj   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

Establishment and validation survival prediction models for T1 locally advanced breast cancer after breast conservation surgery versus mastectomy

Scientific Reports
Previous reports have indicated that the survival rate of total mastectomy (TM) is higher than that of breast-conserving surgery (BCS). This study established survival prediction models for T1-stage locally advanced breast cancer (LABC) comparing TM and ...
Fang Qian, Haoyuan Shen, Chenghao Liu, Dongtao Liu, Wei Chen   +4 more
doaj   +1 more source

Thyroid anomalies with its embryological and clinical correlation

CHRISMED Journal of Health and Research, 2015
Objective: Thyroid gland is the first endocrine gland to start developing in the embryo. It is well-known for its developmental anomalies such as persistence of pyramidal lobe, thyroglossal duct, agenesis of isthmus, agenesis or hemiagenesis of thyroid ...
R Sharada, Chandni Gupta, Sneha Kalthur, Shakuntala R Pai, G B Rairam   +4 more
doaj   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

Advanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li, Zhongya Zhai, Haiyi Yu, Renjie Qiu, Fengyu Li, Luxi Xiao, Boxi Huang, Huiying Liu, Jiayong He, Bowen Cai, Jiawen Chen, Jiang Yu, Guoxin Li, Tao Chen   +13 more
wiley   +1 more source

Morphometry, topography and arterial supply of the thyroid gland in rhesus monkeys (Macaca mulatta Zimmermann, 1780) [PDF]

Brazilian Journal of Biology
The purpose of this research was to investigate the measures, topography, and vascularization of the thyroid gland in Macaca mulatta, a non-human primate. The study involved the dissection of ten male adult cadavers of Macaca mulatta.
A. V. Stocco, R. Medeiros-do-Nascimento, C. T. Messias, C. A Santos-Sousa, P. Souza-Junior, A. Pissinatti, M. Abidu-Figueiredo   +6 more
doaj   +1 more source

Dysfunctional ectopic thyroid gland: A case report [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2014
Introduction. Lingual thyroid gland is a rare anomaly of thyroid gland development, occurring more frequently in females. If it causes local symptomatology such as dysphagia, dysphonia or dyspnea it is diagnosed in childhood, however, if it is ...
Stokić Edita, Kljajić Vladimir, Iđuški Stevan, Benc Damir, Popović Đorđe, Protić Mlađan, Crnobrnja Veljko   +6 more
doaj   +1 more source

RHINO: An Integrative Multi‐Omics Framework Linking Circadian Physiology to Precision Medicine

Advanced Science, EarlyView.
RHINO (RHythmic Interacting Network for multi‐Omics) is an integrative framework that maps circadian regulation across diverse genetic and disease contexts and prioritizes druggable circadian targets. Released as an AI‐powered interactive web portal, RHINO unifies genetic, regulatory, disease, and drug–target information, enabling context‐specific ...
Ying Chen, Chengxuan Chen, Dishu Zhou, Panpan Liu, Roberto E. López‐Valiente, Yuan Liu, Cam Mong La, Isabella Beraldo Xavier, Sean M. Hartig, Pradip Saha, Zheng Sun, Leng Han, Dongyin Guan   +12 more
wiley   +1 more source