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A minimal human physiologically based kinetic model of thyroid hormones and chemical disruption of plasma thyroid hormone binding proteins [PDF]

open access: yesFrontiers in Endocrinology, 2023
The thyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3), are under homeostatic control by the hypothalamic-pituitary-thyroid axis and plasma TH binding proteins (THBPs), including thyroxine-binding globulin (TBG), transthyretin (TTR), and ...
Anish D. Bagga   +2 more
doaj   +2 more sources

Studies on Cytosol Thyroid Hormone Binding Proteins in Rat Liver

open access: diamondFolia Endocrinologica Japonica, 1987
Alterations of binding characteristics of cytosolic thyroid hormone binding proteins (CTHBPs) were examined in livers of rats with different thyroid function. Seven days after thyroidectomy, rats were divided into three groups. Group I received no treatment. Group II was treated with 230 ng triiodothyronine (T3)/100 g body weight per day for three days,
M, Nanno   +5 more
  +9 more sources

µ-Crystallin: A thyroid hormone binding protein [PDF]

open access: yesEndocrine Regulations, 2021
µ-Crystallin is a NADPH-regulated thyroid hormone binding protein encoded by the CRYM gene in humans. It is primarily expressed in the brain, muscle, prostate, and kidney, where it binds thyroid hormones, which regulate metabolism and thermogenesis.
Kinney Christian J., Bloch Robert J.
doaj   +3 more sources

Synthesis of thyroid hormone binding proteins transthyretin and albumin by human trophoblast. [PDF]

open access: yesThe Journal of Clinical Endocrinology & Metabolism, 2005
Context: Mechanisms regulating materno-fetal transfer of thyroid hormone are not well understood. Modulation of trophoblast type 3 iodothyronine deiodinase (D3) may play an important role.Objective: The objective of this study was to investigate trophoblast thyroid hormone binding proteins that may modulate interactions between D3 and T4.Design ...
B. McKinnon   +3 more
semanticscholar   +4 more sources

T3 levels and thyroid hormone signaling

open access: yesFrontiers in Endocrinology, 2022
The clinical availability of tissue-specific biomarkers of thyroid hormone (TH) action constitutes a “holy grail” for the field. Scientists have investigated several TH-dependent markers, including the tissue content of triiodothyronine (T3)—the active ...
Federico Salas-Lucia, Antonio C. Bianco
doaj   +2 more sources

The Free Hormone Hypothesis: When, Why, and How to Measure the Free Hormone Levels to Assess Vitamin D, Thyroid, Sex Hormone, and Cortisol Status

open access: yesJBMR Plus, 2021
The free hormone hypothesis postulates that only the nonbound fraction (the free fraction) of hormones that otherwise circulate in blood bound to their carrier proteins is able to enter cells and exert biologic effects.
Daniel D Bikle
doaj   +2 more sources

Thyroid hormone and thyroid hormone nuclear receptors: History and present state of art

open access: yesEndocrine Regulations, 2021
The present review traces the road leading to discovery of L-thyroxine, thyroid hormone (3,5,3´-triiodo-L-thyronine, T3) and its cognate nuclear receptors.
Brtko Julius
doaj   +2 more sources

Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion

open access: yesFrontiers in Endocrinology, 2022
Thyroid hormones (THs), including T4 and T3, are produced and released by the thyroid gland under the stimulation of thyroid-stimulating hormone (TSH).
Li Jing, Qiang Zhang
doaj   +2 more sources

Studies on the Hormone-Binding Function of Thyroid Hormone-Binding Proteins by Heat Treatment

open access: diamondFolia Endocrinologica Japonica, 1994
Thyroxine-binding globulin (TBG), a major thyroid hormone-binding protein, is denatured by heat and subsequently loses its binding activity. This study aimed to investigate changes in the function of thyroid hormone-binding proteins utilizing a method of heat treatment.
Youichi Ikegami, Nakaaki Ohsawa
openaire   +4 more sources

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