Results 131 to 140 of about 164,300 (382)

The Contribution of Cholesterol and Squalene Synthase in Cancer: Molecular Mechanisms, Lipid Rafts and Therapeutic Approaches

Medicinal Research Reviews, EarlyView.
ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi, Theodora Katavati, Angeliki P. Kourounakis   +2 more
wiley   +1 more source

Characteristics, properties and limitations of per‐ or polyfluoroalkyl substances (PFASs) and fluoropolymers

Polymer International, EarlyView.
An overview and categorization of man‐made per‐ or polyfluoroalkyl substances (PFASs) including low‐molar‐mass and high‐molar‐mass fluorochemicals, and their international regulations is presented. Though certain PFASs are toxic, bioaccumulative and cross the human cellular membranes, others, such as fluoropolymers, are safe, reliable and involved in ...
Bruno Améduri
wiley   +1 more source

Thyroid Hormone-Responsive SPOT 14 Homolog Promotes Hepatic Lipogenesis, and Its Expression Is Regulated By Liver X Receptor α Through a Sterol Regulatory Element-Binding Protein 1c–Dependent Mechanism in Mice [PDF]

, 2013
Jing Wu, Chunjiong Wang, Shuo Li, Sha Li, Wanyi Wang, Jing Li, Yujing Chi, Hang Yang, Xiaomu Kong, Yunfeng Zhou, Chengyan Dong, Fan Wang, Guoheng Xu, Jichun Yang, Jan-Ακε Gustafsson, Youfei Guan   +15 more
openalex   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

High molecular thyrotrophin ("big"-TSH) from human pituitaries : Preparation and partial characterization [PDF]

, 1977
Erhardt, F., Scriba, Peter Christian
core   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Enantioselective maternal transfer of chiral pesticide metabolite o,p’-DDD in zebrafish (Danio rerio): Implications for intergenerational thyroid disruption

Environmental Chemistry and Ecotoxicology
Recent studies show that pesticides can induce intergenerational toxicity, posing threats to wildlife populations. However, the intergenerational effects of chiral pesticide metabolites remain understudied despite their known enantioselective ...
Lili Niu, Honghong Gong, Zhuoye Xue, Xue Li, Kainan Qian, Xinkai Lin, Xiaohui Sun, Jinsong Liu, Chaonan Zhang, Chao Xu, Weiping Liu   +10 more
doaj   +1 more source

Thyroid Hormone Inhibits Vascular Remodeling Through Suppression of cAMP Response Element Binding Protein Activity [PDF]

, 2006
Kae Fukuyama, Toshihiro Ichiki, Ikuyo Imayama, Hideki Ohtsubo, Hiroki Ono, Yasuko Hashiguchi, Akira Takeshita, Kenji Sunagawa   +7 more
openalex   +1 more source

Proteomic profiling of porcine seminal extracellular vesicles reveals potential in vivo fertility biomarkers

Andrology, EarlyView.
Abstract Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in reproductive processes and maybe key to understanding male fertility.
Isabel Barranco, Pablo Martínez‐Díaz, Ana Parra, María José Martínez‐Alborcia, Xiomara Lucas, Heriberto Rodríguez‐Martínez, Jordi Roca   +6 more
wiley   +1 more source

Exploring the Role of Bifenthrin in Recurrent Implantation Failure and Pregnancy Loss Through Network Toxicology and Molecular Docking

Toxics
Bifenthrin (BF) is a widely used pyrethroid pesticide recognized as an endocrine-disrupting chemical (EDC). Previous studies have confirmed that chronic exposure to BF is associated with various health risks.
Shengyuan Jiang, Yixiao Wang, Haiyan Chen, Yuanyuan Teng, Qiaoying Zhu, Kaipeng Xie   +5 more
doaj   +1 more source