Results 11 to 20 of about 164,300 (382)

Sterol regulatory element-binding proteins are regulators of the rat thyroid peroxidase gene in thyroid cells. [PDF]

open access: yesPLoS ONE, 2014
Sterol regulatory element-binding proteins (SREBPs)-1c and -2, which were initially discovered as master transcriptional regulators of lipid biosynthesis and uptake, were recently identified as novel transcriptional regulators of the sodium-iodide ...
Christine Rauer   +4 more
doaj   +1 more source

Evolution of the Thyroid Hormone-Binding Protein, Transthyretin [PDF]

open access: yesGeneral and Comparative Endocrinology, 2000
Transthyretin (TTR) belongs to a group of proteins, which includes thyroxine-binding globulin and albumin, that bind to and transport thyroid hormones in the blood. TTR is also indirectly implicated in the carriage of vitamin A through the mediation of retinol-binding protein (RBP). It was first identified in 1942 in human serum and cerebrospinal fluid
Power, Deborah   +5 more
openaire   +3 more sources

Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat [PDF]

open access: yes, 2002
Earlier studies at our laboratory indicated that several hydroxylated polychlorinated biphenyls (OH-PCBs) detected in human blood could specifically inhibit thyroxine (T4) transport by competitive binding to the thyroid hormone transport protein ...
Assink, Y.   +7 more
core   +7 more sources

Laboratory Assessment of Thyroid Function in Patients with Proteinuria [PDF]

open access: yesJournal of Biomedical & Clinical Research, 2018
Significant losses of functional proteins such as hormones and hormone-binding proteins are seen in patients suffering from proteinuria. Studies have reported loss of thyroid hormones and thyroxine-binding globulin in the urine.
Irena Gencheva-Angelova   +2 more
doaj   +3 more sources

Assessment of the endocrine-disrupting effects of diethyl phosphate, a nonspecific metabolite of organophosphorus pesticides, by in vivo and in silico approaches

open access: yesEnvironment International, 2020
Organophosphorus pesticides (OPs) remain one of the most commonly used pesticides, and their detection rates and residues in agricultural products, foods and environmental samples have been underestimated.
Fang-Wei Yang   +4 more
doaj   +1 more source

Endoplasmic reticulum stress inhibits expression of genes involved in thyroid hormone synthesis and their key transcriptional regulators in FRTL-5 thyrocytes. [PDF]

open access: yesPLoS ONE, 2017
Endoplasmic reticulum (ER) stress is characterized by the accumulation of misfolded proteins due to an impairment of ER quality control pathways leading to the activation of a defense system, called unfolded protein response (UPR).
Gaiping Wen, Robert Ringseis, Klaus Eder
doaj   +1 more source

The Effect of Chronic Renal Failure on Thyroid Hormones

open access: yesIraqi Journal of Pharmaceutical Sciences, 2017
Chronic renal failure (CRF) affects thyroid function in multiple ways, including low circulating thyroid hormone concentration, altered peripheral hormone metabolism, disturbed binding to carrier proteins, possible reduction in tissue thyroid hormone ...
Layla K. Ali
doaj   +3 more sources

Persisting neuroendocrine abnormalities and their association with physical impairment 5 years after critical illness

open access: yesCritical Care, 2021
Background Critical illness is hallmarked by neuroendocrine alterations throughout ICU stay. We investigated whether the neuroendocrine axes recover after ICU discharge and whether any residual abnormalities associate with physical functional impairments
Ilse Vanhorebeek   +5 more
doaj   +1 more source

Urinary excretion of thyroid hormone in CKD patients: a proof-of-concept of nephrogenic hypothyroidism

open access: yesRenal Failure, 2023
Purpose Patients with chronic kidney disease (CKD) complicated by hypothyroidism exhibit a higher prevalence of urine protein than that in the general population. This study was aimed at investigating thyroid hormones and thyroid hormone-binding proteins
Rena Yuasa   +6 more
doaj   +1 more source

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