A minimal human physiologically based kinetic model of thyroid hormones and chemical disruption of plasma thyroid hormone binding proteins [PDF]
Frontiers in Endocrinology, 2023 The thyroid hormones (THs), thyroxine (T4) and triiodothyronine (T3), are under homeostatic control by the hypothalamic-pituitary-thyroid axis and plasma TH binding proteins (THBPs), including thyroxine-binding globulin (TBG), transthyretin (TTR), and ...
Anish D. Bagga +2 more
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µ-Crystallin: A thyroid hormone binding protein [PDF]
Endocrine Regulations, 2021 µ-Crystallin is a NADPH-regulated thyroid hormone binding protein encoded by the CRYM gene in humans. It is primarily expressed in the brain, muscle, prostate, and kidney, where it binds thyroid hormones, which regulate metabolism and thermogenesis.
Kinney Christian J., Bloch Robert J.
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Cytosolic thyroid hormone-binding protein is a monomer of pyruvate kinase [PDF]
Proceedings of the National Academy of Sciences, 1990 openalex +2 more sources
Studies on the Hormone-Binding Function of Thyroid Hormone-Binding Proteins by Heat Treatment
Folia Endocrinologica Japonica, 1994 Thyroxine-binding globulin (TBG), a major thyroid hormone-binding protein, is denatured by heat and subsequently loses its binding activity. This study aimed to investigate changes in the function of thyroid hormone-binding proteins utilizing a method of heat treatment.
Youichi Ikegami, Nakaaki Ohsawa
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JBMR Plus, 2021 The free hormone hypothesis postulates that only the nonbound fraction (the free fraction) of hormones that otherwise circulate in blood bound to their carrier proteins is able to enter cells and exert biologic effects.
Daniel D Bikle
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Sterol regulatory element-binding proteins are regulators of the rat thyroid peroxidase gene in thyroid cells. [PDF]
PLoS ONE, 2014 Sterol regulatory element-binding proteins (SREBPs)-1c and -2, which were initially discovered as master transcriptional regulators of lipid biosynthesis and uptake, were recently identified as novel transcriptional regulators of the sodium-iodide ...
Christine Rauer +4 more
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T3 levels and thyroid hormone signaling
Frontiers in Endocrinology, 2022 The clinical availability of tissue-specific biomarkers of thyroid hormone (TH) action constitutes a “holy grail” for the field. Scientists have investigated several TH-dependent markers, including the tissue content of triiodothyronine (T3)—the active ...
Federico Salas-Lucia, Antonio C. Bianco
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Laboratory Assessment of Thyroid Function in Patients with Proteinuria [PDF]
Journal of Biomedical & Clinical Research, 2018 Significant losses of functional proteins such as hormones and hormone-binding proteins are seen in patients suffering from proteinuria. Studies have reported loss of thyroid hormones and thyroxine-binding globulin in the urine.
Irena Gencheva-Angelova +2 more
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Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat [PDF]
, 2002 Earlier studies at our laboratory indicated that several hydroxylated polychlorinated biphenyls (OH-PCBs) detected in human blood could specifically inhibit thyroxine (T4) transport by competitive binding to the thyroid hormone transport protein ...
Assink, Y. +7 more
core +7 more sources
Evolution of the Thyroid Hormone-Binding Protein, Transthyretin [PDF]
General and Comparative Endocrinology, 2000 Transthyretin (TTR) belongs to a group of proteins, which includes thyroxine-binding globulin and albumin, that bind to and transport thyroid hormones in the blood. TTR is also indirectly implicated in the carriage of vitamin A through the mediation of retinol-binding protein (RBP). It was first identified in 1942 in human serum and cerebrospinal fluid
Power, Deborah +5 more
openaire +3 more sources