Results 21 to 30 of about 108,163 (351)

Assessment of the endocrine-disrupting effects of diethyl phosphate, a nonspecific metabolite of organophosphorus pesticides, by in vivo and in silico approaches

open access: yesEnvironment International, 2020
Organophosphorus pesticides (OPs) remain one of the most commonly used pesticides, and their detection rates and residues in agricultural products, foods and environmental samples have been underestimated.
Fang-Wei Yang   +4 more
doaj   +1 more source

Spatially Dependent Tissue Distribution of Thyroid Hormones by Plasma Thyroid Hormone Binding Proteins

open access: yesPflügers Archiv - European Journal of Physiology, 2023
AbstractPlasma thyroid hormone (TH) binding proteins (THBPs), including thyroxine-binding globulin (TBG), transthyretin (TTR), and albumin (ALB), carry THs to extrathyroidal sites, where THs are unloaded locally and then taken up via membrane transporters into the tissue proper.
Anish D. Bagga   +2 more
openaire   +3 more sources

Synthesis of Thyroid Hormone Binding Proteins Transthyretin and Albumin by Human Trophoblast [PDF]

open access: bronzeThe Journal of Clinical Endocrinology & Metabolism, 2005
Context: Mechanisms regulating materno-fetal transfer of thyroid hormone are not well understood. Modulation of trophoblast type 3 iodothyronine deiodinase (D3) may play an important role.Objective: The objective of this study was to investigate trophoblast thyroid hormone binding proteins that may modulate interactions between D3 and T4.Design ...
Brett McKinnon   +3 more
openalex   +4 more sources

Endoplasmic reticulum stress inhibits expression of genes involved in thyroid hormone synthesis and their key transcriptional regulators in FRTL-5 thyrocytes. [PDF]

open access: yesPLoS ONE, 2017
Endoplasmic reticulum (ER) stress is characterized by the accumulation of misfolded proteins due to an impairment of ER quality control pathways leading to the activation of a defense system, called unfolded protein response (UPR).
Gaiping Wen, Robert Ringseis, Klaus Eder
doaj   +1 more source

The Effect of Chronic Renal Failure on Thyroid Hormones

open access: yesIraqi Journal of Pharmaceutical Sciences, 2017
Chronic renal failure (CRF) affects thyroid function in multiple ways, including low circulating thyroid hormone concentration, altered peripheral hormone metabolism, disturbed binding to carrier proteins, possible reduction in tissue thyroid hormone ...
Layla K. Ali
doaj   +3 more sources

Persisting neuroendocrine abnormalities and their association with physical impairment 5 years after critical illness

open access: yesCritical Care, 2021
Background Critical illness is hallmarked by neuroendocrine alterations throughout ICU stay. We investigated whether the neuroendocrine axes recover after ICU discharge and whether any residual abnormalities associate with physical functional impairments
Ilse Vanhorebeek   +5 more
doaj   +1 more source

Urinary excretion of thyroid hormone in CKD patients: a proof-of-concept of nephrogenic hypothyroidism

open access: yesRenal Failure, 2023
Purpose Patients with chronic kidney disease (CKD) complicated by hypothyroidism exhibit a higher prevalence of urine protein than that in the general population. This study was aimed at investigating thyroid hormones and thyroid hormone-binding proteins
Rena Yuasa   +6 more
doaj   +1 more source

Potential Disruption of Systemic Hormone Transport by Tobacco Alkaloids Using Computational Approaches

open access: yesToxics, 2022
Tobacco/nicotine is one of the most toxic and addictive substances and continues to pose a significant threat to global public health. The harmful effects of smoking/nicotine affect every system in the human body.
Mohd Rehan   +6 more
doaj   +1 more source

Glycosylation in the thyroid gland : vital aspects of glycoprotein function in thyrocyte physiology and thyroid disorders [PDF]

open access: yes, 2018
The key proteins responsible for hormone synthesis in the thyroid are glycosylated. Oligosaccharides strongly affect the function of glycosylated proteins.
Ewa Pocheć   +2 more
core   +1 more source

Molecular docking studies of human MCT8 protein with soy isoflavones in Allan-Herndon-Dudley syndrome (AHDS)

open access: yesJournal of Pharmaceutical Analysis, 2018
Monocarboxylate transporter-8 (MCT8) is a specific thyroid hormone transporter, essential for the uptake of thyroid hormone into target tissues. Mutations in the MCT8 gene have been identified as the cause of Allan-Herndon-Dudley syndrome (AHDS).
Divya Shaji
doaj   +1 more source

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