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Thyroid hormone binding protein contains glycosylation site binding protein activity
Biochemical and Biophysical Research Communications, 1990Several lines of evidence provided by other workers indicate that within the same species thyroid hormone binding protein, the beta-subunit of prolyl hydroxylase, and protein disulfide isomerase are the same protein. We sought to determine if glycosylation site binding protein, a lumenal protein of the endoplasmic reticulum, also has the same primary ...
H, Kimura +6 more
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Thyroid Hormone-Binding Plasma Proteins
1986The thyroid hormones thyroxine (T4) and 3,3′,5-triiodothyronine (T3) are bound to serum proteins for more than 99%. These proteins are thyroxine-binding protein (TBG), thyroxine-binding prealbumin (TBPA), and albumin. TBG is the most important T4 transport protein as it binds about 75 to 80% of T4, while both TBPA and albumin bind approximately 10% (1).
Georg Hennemann +2 more
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Glutathione-S-transferases are major cytosolic thyroid hormone binding proteins
Archives of Biochemistry and Biophysics, 1989Thyroid hormone binding proteins of rat liver cytosol were characterized. Glutathione-S-transferases were identified among major cytosolic proteins adsorbed by thyroxine affinity matrices. The Ya and Yb subunits of the glutathione-S-transferases were also principal proteins of cytosol covalently labeled with 3,3',5-triiodo-L-thyronine (T3) or 3,3',5,5'-
S, Ishigaki, M, Abramovitz, I, Listowsky
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A cytoplasmic thyroid hormone binding protein: characterization using monoclonal antibodies
Biochemistry, 1989We have previously purified a cellular thyroid hormone binding protein (p58) from a human carcinoma cell line [Kitagawa, S., Obata, T., Hasumura, S., Pastan, I., & Cheng, S.-y. (1987) J. Biol. Chem. 262, 3903-3908]. In the present study, the binding characteristics, the molecular properties, and subcellular localization of p58 were further ...
T, Obata +4 more
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Recent Achievements in Studies on Thyroid Hormone-Binding Proteins*
Endocrine Reviews, 1990Introduction THYROID hormones circulate in the bloodstream mostly bound to a set of plasma proteins which widely differ in their concentration and affinity for the hormones (1). The three major transport proteins are T4-binding globulin (TBG), T4-binding prealbumin (TBPA), and albumin.
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Effects of hypo or hyper‐thyroidism on growth hormone‐binding protein
Clinical Endocrinology, 1991Summary. objective Growth hormone (GH) receptors are Influenced by the thyroidal state of experimental animals. It has been suggested that GH‐binding protein (BP) might serve as an Indirect measure of the GH receptors. The present study was undertaken to investigate the growth hormone binding protein in patients with hypo or hyperthyroidism.patients ...
T, Amit +6 more
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Purification and partial characterization of thyroid hormone binding proteins in canine serum
Domestic Animal Endocrinology, 1987Thyroxine-binding prealbumin (TBPA) and thyroxine-binding globulin (TBG) were isolated from canine serum and partially characterized. TBPA was isolated by retinol-binding protein (RBP) affinity chromatography and further purified by preparative agarose gel electrophoresis or FPLC ion exchange chromatography. TBG was purified by thyroxine (T4)-Sepharose
M, Larsson, T, Pettersson
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Reviews on Environmental Health, 2006
In vertebrates, thyroid hormones are essential for post-embryonic development, such as establishing the central nervous system in mammals and metamorphosis in amphibians. The present paper summarizes the possible extra-thyroidal processes that environmental chemicals are known to or suspected to target in the thyroid hormone-signaling pathway.
Kiyoshi, Yamauchi, Akinori, Ishihara
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In vertebrates, thyroid hormones are essential for post-embryonic development, such as establishing the central nervous system in mammals and metamorphosis in amphibians. The present paper summarizes the possible extra-thyroidal processes that environmental chemicals are known to or suspected to target in the thyroid hormone-signaling pathway.
Kiyoshi, Yamauchi, Akinori, Ishihara
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The Journal of Clinical Endocrinology & Metabolism, 1979
A 9-yr-old boy is described in whom increased serum T4 concentration, increased T3 uptake, and increased free T4 index were associated with a euthyroid clinical state with normal total serum T3. T4-binding globulin (TBG), measured by RIA, was decreased.
W N, Lee +4 more
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A 9-yr-old boy is described in whom increased serum T4 concentration, increased T3 uptake, and increased free T4 index were associated with a euthyroid clinical state with normal total serum T3. T4-binding globulin (TBG), measured by RIA, was decreased.
W N, Lee +4 more
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Secretion and transfer of the thyroid hormone binding protein transthyretin by human placenta
Placenta, 2012The thyroid hormone and retinol binding protein transthyretin (TTR) is synthesised by human trophoblasts. Polarised JEG-3 choriocarcinoma cells grown in bicameral chambers secrete TTR predominantly apically but also basally and these cells and human trophoblasts also take up TTR suggesting that there may be a placental TTR shuttle that participates in ...
Mortimer, Robin +6 more
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