Results 351 to 360 of about 467,905 (403)

Thyroid Hormone Signaling and the Liver

Hepatology, 2020
Thyroid hormone (TH) plays a critical role in maintaining metabolic homeostasis throughout life. It is well known that the liver and thyroid are intimately linked, with TH playing important roles in de novo lipogenesis, beta‐oxidation (fatty acid ...
M. Ritter, I. Amano, A. Hollenberg
semanticscholar   +1 more source

Thyroid Hormone Receptors

2010
Thyroid hormone promotes a diverse range of developmental, neurological and metabolic functions in vertebrate species. Human thyroid disorders result in a correspondingly wide range of disease symptoms. The functions of thyroid hormone are mediated by a small group of thyroid hormone receptors encoded by two conserved genes.
BjÖRn VennstrÖM, Hong Liu, Douglas Forrest   +2 more
openaire   +1 more source

Nongenomic Actions of Thyroid Hormone: the Integrin Component.

Physiological Reviews, 2020
The extracellular domain of plasma membrane integrin αvβ3 contains a cell surface receptor for thyroid hormone analogues. The receptor is largely expressed and activated in tumor cells and rapidly dividing endothelial cells. The principal ligand for this
P. Davis, S. Mousa, Hung-Yun Lin
semanticscholar   +1 more source

Thyroid hormone receptors and reproduction

Journal of Reproductive Immunology, 2011
Thyroid disorders have a great impact on fertility in both sexes. Hyperthyroidism and hypothyroidism cause changes in sex hormone-binding globulin (SHBG), prolactin, gonadotropin-releasing hormone, and sex steroid serum levels. In females, thyroid hormones may also have a direct effect on oocytes, because it is known that specific binding sites for ...
Ralf, Dittrich, Matthias W, Beckmann, Patricia G, Oppelt, Inge, Hoffmann, Laura, Lotz, Torsten, Kuwert, Andreas, Mueller   +6 more
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Thyroid Hormone Receptors

Comprehensive Physiology, 1998
Abstract The sections in this article are: 3,5,3′ Triiodo‐ L ‐Thyronine (T 3 ) Receptors: Overview
openaire   +1 more source

Selective Thyroid Hormone Receptor Modulators

Current Topics in Medicinal Chemistry, 2003
Thyroid hormone regulates many important processes in vertebrates. Analysis of the symptoms that accompany hypo- and hyperthyroidism, the most common disorders of the thyroid, suggests that there are certain desirable biological effects brought about by an excess or deficiency of thyroid hormone, and that selective thyroid hormone receptor modulators ...
Hikari A I, Yoshihara, Thomas S, Scanlan
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Thyroid Hormone Receptors and Responses

1979
Publisher Summary This chapter discusses the responses of thyroid hormone receptors. The thyroid hormone receptor is unique in that it is an intrinsic chromosomal nonhistone protein known to be involved in the regulation of the expression of specific genes. These receptors are bound to chromatin in the absence or the presence of thyroid hormone. They
J D, Baxter, N L, Eberhardt, J W, Apriletti, L K, Johnson, R D, Ivarie, B S, Schachter, J A, Morris, P H, Seeburg, H M, Goodman, K R, Latham, J R, Polansky, J A, Martial   +11 more
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Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance

Trends in Endocrinology & Metabolism, 2005
Thyroid hormone receptors (TRs) are ligand-dependent transcription factors that mediate the biological activities of thyroid hormone (T3). Two THR genes (A and B), located on different chromosomes, yield four T3-binding isoforms with highly conserved sequences in the DNA- and ligand-binding domains.
openaire   +2 more sources

The Thyroid Hormone Receptors: Molecular Basis of Thyroid Hormone Resistance

Hormone Research, 1992
Major progress has been achieved in the mechanism of action of thyroid hormones thanks to the identification of the T3 receptor as the product of the proto-oncogene c-erbA. Recognition of subsets of receptors with and without T3-binding properties and of the interaction of different receptors with each other leads to new insights in cell regulation and
openaire   +2 more sources

Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor

Nature, 1995
A. Hörlein, A. Näär, T. Heinzel, J. Torchia, B. Gloss, R. Kurokawa, A. Ryan, Yasutomi Kamei, M. Söderström, C. Glass, M. Rosenfeld   +10 more
semanticscholar   +1 more source