Results 131 to 140 of about 449,550 (308)

Design of azine antioxidants for sustainable biodiesel: integrating structural characterization and molecular modeling

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract The growing global demand for sustainable energy solutions has intensified the search for renewable alternatives to fossil fuels, with biodiesel emerging as a promising candidate due to its biodegradability and lower emissions. However, its large‐scale application is limited by low oxidative stability, which compromises storage and performance.
Patricia R. S. Wenceslau, Chris H. J. Franco, Leonardo R. de Almeida, Vitor S. Duarte, Ronaldo G. F. Junior, Guilherme Paixão, Antônio S. N. Aguiar, Gilberto L. B. de Aquino, Leonardo G. Costa, Leonardo L. Borges, Hamilton B. Napolitano   +10 more
wiley   +1 more source

Thyroid hormone and the Liver

Hepatology Communications
It is known that thyroid hormone can regulate hepatic metabolic pathways including cholesterol, de novo lipogenesis, fatty acid oxidation, lipophagy, and carbohydrate metabolism. Thyroid hormone action is mediated by the thyroid hormone receptor (THR) isoforms and their coregulators, and THRβ is the main isoform expressed in the liver. Dysregulation of
Lorraine Soares De Oliveira, Megan J. Ritter   +1 more
openaire   +2 more sources

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Evaluation of Ghrelin and Leptin in Patients with Thyroid Malfunction [PDF]

Journal of Kerman University of Medical Sciences, 2005
Introduction: Leptin and Ghrelin are hormones that have been discovered in the last decade and were shown to be involved in appetite and metabolism regulation and body weight.
Gh.R Moshtaghi-Kashanian, A Gholamhoseinian, M Sanjari, M Kor   +3 more
doaj  

Exposure‐adjusted safety and efficacy of GLP‐I and GLP‐1/GIP receptor agonists compared with non‐GLP‐I for weight management and type 2 diabetes: Based on FDA medical and statistical reports of 34 280 safety and 36 312 efficacy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims This work aimed to contextualize glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and glucose‐dependent insulinotropic polypeptide (GIP) receptor agonists safety and efficacy regarding weight management (WM); we analysed Food and Drug Administration (FDA) Medical Reviews to analyse 14 medications using patient‐exposure year normalization and ...
Aishwarya Prasad, Anshu Arora, Arun Arora, Jeena Vaid, Arif Khan   +4 more
wiley   +1 more source

Regulatory harmonization: Evolution, globalization and future directions

British Journal of Clinical Pharmacology, EarlyView.
Regulatory harmonization has become an increasingly important and accepted approach to streamline regulatory review processes and expedite access to safe, effective and high‐quality medicines globally. This review explores the evolution and current status of regulatory harmonization, convergence and reliance initiatives.
Orin Chisholm, Elaine Y. L. Blair, Christine Y. Lu   +2 more
wiley   +1 more source

Thyroid-related hormones and hypertension incidence in middle aged and older Hispanic/Latino adults - Supplemental Materials

Supplemental materials for manuscript - Abasilim, C., Persky, V., Sargis, R.M. et al.  Abasilim, C., Persky, V., Sargis, R. M., Argos, M., Daviglus, M. L., Freels, S., ... & Turyk, M. E. (2023). Association of Acculturation and Hispanic/Latino Background
Bharat Thyagarajan (14034686), Mary Turyk (10636754), Victoria Persky (10640843), Robert Sargis (10638503), Sally Freels (10638701), Chibuzor Abasilim (17076343), Gregory A. Talavera (17077279), Konstantina Tsintsifas (17463624), Brandilyn A Peters (15213273), Maria Argos (10592741), Martha Daviglus (10630433), Carmen R. Isasi (7246739)   +11 more
core   +1 more source

Safety outcomes of antidiabetic medications: A comprehensive review of the EU summaries of product characteristics and international clinical practice guidelines

British Journal of Clinical Pharmacology, EarlyView.
Aims Information on the safety profile of antidiabetic medications is essential for informed treatment decisions in type 2 diabetes mellitus. Although this information is available in regulatory documents of individual drugs, a comprehensive overview across all approved antidiabetics is lacking.
David Liang, Daniala L. Weir, Safana Thevasahayam, Vera H. M. Deneer, Arno Siebes, Helga Gardarsdottir   +5 more
wiley   +1 more source

Per- and polyfluoroalkyl substance profiles and associations with thyroid hormones in a coal mining population from Shanxi Province, China

Environment International
Background: Per- and polyfluoroalkyl substances (PFASs) exposure may cause endocrine disruption. However, PFAS exposure and their potential associations with thyroid hormones remain unclear in coal mining areas.
Liangpo Liu, Yufan Cheng, Zhipeng Sun, Yu Gao, Lu He, Yingxiao Yue, Shuqi Xu, Yalin Liu, Dan Wang, Hongying Gao, Wei Yan, Huan Song, Xiujuan Yang, Jianquan Guo, Ben Li, Qiansheng Huang, Qian Gao, Jinzhu Yin, Tong Wang   +18 more
doaj   +1 more source

New therapeutic options for metabolic‐associated steatotic liver disease

British Journal of Clinical Pharmacology, EarlyView.
An increasing number of patients are being diagnosed with metabolic dysfunction‐associated steatotic liver disease (MASLD). MASLD results from disturbances in hepatic lipid metabolism and is associated with an increased risk of cirrhosis and hepatocellular carcinoma and significant extrahepatic morbidity, including cardiovascular disease and ...
Tessa Straatmijer, Midas Mulder
wiley   +1 more source