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Nongenomic Actions of Thyroid Hormones: From Basic Research to Clinical Applications. An Update
, 2013Extranuclear or nongenomic actions of thyroid hormones are unaffected by the inhibitors of protein synthesis, their site of action has been localized at the plasma membrane but also in the cytoplasm and organelles such as the mitochondria.
R. G. Ahmed +7 more
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Annual Review of Medicine, 1992
Generalized resistance to thyroid hormone (GRTH) encompasses a heterogeneous group of conditions characterized by reduced responses of target tissues to thyroid hormone due to defects at the site of hormone action. In the majority of patients, GRTH is inherited as a dominant trait associated with mutations in the hormone-binding domain of the thyroid ...
Roy E. Weiss, Samuel Refetoff
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Generalized resistance to thyroid hormone (GRTH) encompasses a heterogeneous group of conditions characterized by reduced responses of target tissues to thyroid hormone due to defects at the site of hormone action. In the majority of patients, GRTH is inherited as a dominant trait associated with mutations in the hormone-binding domain of the thyroid ...
Roy E. Weiss, Samuel Refetoff
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Current Opinion in Endocrinology, Diabetes & Obesity, 2012
To review several of the most recent and most important clinical studies regarding the effects of thyroid treatments on weight change, associations between thyroid status and weight, and the effects of obesity and weight change on thyroid function.Weight decreases following treatment for hypothyroidism.
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To review several of the most recent and most important clinical studies regarding the effects of thyroid treatments on weight change, associations between thyroid status and weight, and the effects of obesity and weight change on thyroid function.Weight decreases following treatment for hypothyroidism.
openaire +2 more sources
Metabolism of the Thyroid Hormones
Hormone Research, 1987This review covers the current knowledge about the various metabolic pathways involved in the conversion of thyroid hormones to the thyromimetically active and inactive iodothyronines. The concerted mechanism of systemic and local production of iodothyronines by tissue-specific iodothyronine deiodinase isozymes will ultimately determine the expression ...
Josef Köhrle +2 more
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Thyroid Hormones and Derivatives: Endogenous Thyroid Hormones and Their Targets
2018More than a century after the discovery of L-Thyroxine, the main thyroid hormone secreted solely by the thyroid gland, several metabolites of this iodinated, tyrosine-derived ancestral hormone have been identified. These are utilized as hormones during development, differentiation, metamorphosis, and regulation of most biochemical reactions in ...
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Endocrine Research, 1988
The gastrointestinal tract interacts actively with the thyroid hormones, T4 and T3. Both T4 and T3 are absorbed well but incompletely from the gut, and many factors affect this absorption. The mechanism of absorption is unknown. It is decreased in most malabsorption conditions, but is increased in the postgastrojejunotomy syndrome.
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The gastrointestinal tract interacts actively with the thyroid hormones, T4 and T3. Both T4 and T3 are absorbed well but incompletely from the gut, and many factors affect this absorption. The mechanism of absorption is unknown. It is decreased in most malabsorption conditions, but is increased in the postgastrojejunotomy syndrome.
openaire +3 more sources
Hormonal Signaling in Biology and Medicine, 2020
Yan-Yun Liu, A. Milanesi, G. Brent
semanticscholar +1 more source
Yan-Yun Liu, A. Milanesi, G. Brent
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The Role of Thyroid Hormones in Heart Failure
Cardiovascular Drugs and Therapy, 2019C. Vale +4 more
semanticscholar +1 more source