Results 101 to 110 of about 47,115 (244)

Pembrolizumab for Early‐Stage Triple‐Negative Breast Cancer: KEYNOTE‐522 Japan Subgroup Analysis

Cancer Science, EarlyView.
In the global, phase 3 KEYNOTE‐522 study of high‐risk early‐stage triple‐negative breast cancer (TNBC), neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab improved efficacy outcomes versus neoadjuvant chemotherapy alone. In this analysis of Japanese participants from KEYNOTE‐522, neoadjuvant pembrolizumab plus chemotherapy ...
Masato Takahashi, Hirofumi Mukai, Toshimi Takano, Koichiro Tsugawa, Kenichi Inoue, Mitsuya Itoh, Junichiro Watanabe, Yuko Tanabe, Naohito Yamamoto, Yasuo Miyoshi, Kenichi Watanabe, Toru Mukohara, Yibin Kong, Masashi Shimura, Francisco Beca, Peter Schmid, Hiroji Iwata   +16 more
wiley   +1 more source

Anti-Müllerian hormone: Predictor of premature ovarian insufficiency in Egyptian women with autoimmune thyroiditis

Middle East Fertility Society Journal, 2018
Background: Menopause associated with hormone-sensitive co-morbidity such as breast cancer, endometrial cancer, osteoporosis, and cardiovascular disease. Autoimmunity is one of the leading causes of primary ovarian insufficiency (POI). Thyroiditis is the
Nearmeen M. Rashad, Hala Moafy, Hend S. Saleh, Abdelaziz I. Amin, Ahmed F. Gomaa   +4 more
doaj   +1 more source

Evaluating the Link Between Thyroid Function Test Results and Levothyroxine Dose in the Management of Hypothyroidism: Can We Improve Dosing Regimes?

Clinical Endocrinology, EarlyView.
ABSTRACT Introduction Over 10 million thyroid function tests (TFTs) are carried out in England each year, most requests coming from primary care. Our previous work showed that only 25% of results for patients being treated with Levothyroxine fell within the TSH/FT4 boundary circumscribing 75% of untreated individuals.
Adrian H. Heald, Lakdasa D. Premawardhana, Peter N. Taylor, Suhani Bahl, Onyebuchi E. Okosieme, Anthony A. Fryer, Antonio Bianco, Colin M. Dayan, Michael P. Stedman   +8 more
wiley   +1 more source

A novel homozygous mutation of the AIRE gene in an APECED patient from Pakistan: case report and review of the literature [PDF]

, 2018
Autoimmune-poly-endocrinopathy-candidiasis-ectodermal-dystrophy syndrome (APECED) is a rare monogenic recessive disorder caused by mutations in the autoimmune regulator (AIRE) gene.
Bellacchio, Emanuele, Betterle, Corrado, Dhamo, Rudina, Fierabracci, Alessandra, Frasca, Federica, Pellegrino, Marsha   +5 more
core   +2 more sources

Thyroid autoimmunity [PDF]

Journal of Clinical Investigation, 2001
B, Rapoport, S M, McLachlan
openaire   +2 more sources

Vitamin D supplementation in patients with Hashimoto’s disease

Journal of Education, Health and Sport
Introduction : Hashimoto’s thyroiditis (HT) is the most common autoimmune disease and the leading cause of hypothyroidism in the world. The condition results in damage to the thyroid gland, brought about by the infiltration of lymphocytes.
Amelia Kasprzak, Aleksandra Mańkowska, Monika Truchta, Agata Kolano, Wiktoria Jabłońska, Marta Wardęszkiewicz, Szymon Markowiak, Maciej Świercz, Anna Pejas   +8 more
doaj   +1 more source

Epidemiology and Genetics of Rheumatic Diseases Suggest a Constant Rate of DNA Damage as Underlying Cause

Immunology, EarlyView.
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley   +1 more source

Autoimmune thyroiditis [PDF]

, 2006
The term autoimmune thyroiditis encompasses a group of high prevalence thyroid disorders, which have been classified in different ways throughout the years. In this article some aspects related to its classification, epidemiology, susceptibility factors,
Melo, M
core  

Immune cell infiltration correlates with intestinal permeability, inflammation, and gastrointestinal symptoms in type 1 diabetes

Journal of Diabetes Investigation, EarlyView.
In individuals with type 1 diabetes, immune cell infiltration in the colon mucosa tended to correlate with fecal and systemic markers of intestinal permeability and inflammation, as well as gastrointestinal symptoms. These findings suggest that low‐grade gut immune activation might link the intestinal barrier dysfunction with systemic endotoxin ...
Polina Zalizko, Reinis Isaks, Leonora Pahirko, Aleksejs Fedulovs, Eduards Krustins, Jurijs Nazarovs, Sergejs Dubencovs, Hanne Salmenkari, Markku Lehto, Kaspars Jēkabsons, Una Riekstiņa, Per‐Henrik Groop, Niina Sandholm, Jeļizaveta Sokolovska   +13 more
wiley   +1 more source

Molecular estimation of alteration in intestinal microbial composition in Hashimoto's thyroiditis patients [PDF]

, 2017
The gut microbiota has a crucial effect on human health and physiology. Hypothyroid Hashimoto’s thyroiditis (HT) is an autoimmune disorder manifested with environmental and genetic factors.
Guo, Hui, Hou, Yin Jian, Ishaq, Hafiz Muhammad, Ma, Chaofeng, Mohammad, Imran Shair, Naseem, Zahid, Shahzad, Muhammad, Shi, Peijie, Wu, Xiaokang, Xu, Jiru   +9 more
core   +2 more sources