Results 41 to 50 of about 2,969 (182)

Gabpα‐Pparγ Complex Determines Glycolytic Capacity and Lactic Acid Homeostasis in Brown Fat

Advanced Science, Volume 13, Issue 8, 9 February 2026.
This study identifies the Gabpα–Pparγ complex as a key transcriptional regulator that couples glycolysis to lactate‐driven thermogenesis in brown adipose tissue by directly activating Eno1 transcription. ‌Competitive disruption of this interaction impairs lactate metabolism and thermogenic capacity.
Zhihan Wang, Huanyu Wang, Qianqian Kang, Ruping Pan, Rui He, Min Yang, Jiadai Liu, Xuemin Peng, Yuyu Xie, Hongyan Deng, Wenshe Wang, Zengzhe Zhu, Jing Ge, Yulian Liu, Ronghui Gao, Yaming Guo, Peng Yu, Limeng Pan, Danpei Li, Pema Maretich, Xiaoping Luo, Xuefeng Yu, Yong Chen   +22 more
wiley   +1 more source

A Human Model of Oligodendrocyte Development Shows MCL‐1 Influences Oligodendrocyte Morphogenesis

Glia, Volume 74, Issue 2, February 2026.
A unified model of oligodendrocyte differentiation from human embryonic stem cells revealed that MCL‐1 is critical for regulating the expression of oligodendrocyte‐related genes and the morphogenesis of myelinating oligodendrocytes. ABSTRACT Oligodendrocytes are the myelinating cells of the central nervous system.
Melanie Gil, Marina R. Hanna, Vivian Gama   +2 more
wiley   +1 more source

Validation of grizzly bear hair hormone profiles as a tool to monitor population demographics

The Journal of Wildlife Management, Volume 90, Issue 2, February 2026.
We measured 16 steroid and thyroid hormone concentrations in grizzly bear hair to predict sex, age class, and reproductive status. Models were highly accurate when predicting sex and age class and showed promise for assessing reproductive status. Results illustrate the potential for hair hormone profiles as non‐invasive population monitoring tools ...
Abbey E. Wilson, Cameron J. R. McClelland, Sarah A. Michaud, Jun Han, Gordon Stenhouse, David R. Goodlett, Kristenn Magnusson, Karen Graham, Hugo Fernández‐Bellon, David M. Janz, Darío Fernández‐Bellon   +10 more
wiley   +1 more source

Up-take of thyronines and 3-iodothyronamine in liver cells

, 2012
Objectives: 3,5-diiodothyronine (T2) and 3-iodothyronamine (T1AM) are thyroid hormone derivatives which have been shown to produce significant biological effects. Some of these effects appear to involve the interaction with specific intracellular targets.
SABA, ALESSANDRO, GHELARDONI, SANDRA, CHIELLINI, GRAZIA, Marchini M, ZUCCHI, RICCARDO, Frascarelli S   +5 more
core  

Effect of Combined Levothyroxine (L-T₄) and 3-Iodothyronamine (T₁AM) Supplementation on Memory and Adult Hippocampal Neurogenesis in a Mouse Model of Hypothyroidism. [PDF]

Int J Mol Sci, 2023
Rutigliano G, Bertolini A, Grittani N, Frascarelli S, Carnicelli V, Ippolito C, Moscato S, Mattii L, Kusmic C, Saba A, Origlia N, Zucchi R.   +11 more
europepmc   +1 more source

Substantial impact of 3-iodothyronamine (T1AM) on the regulations of fluorescent thermoprobe-measured cellular temperature and natriuretic peptide expression in cardiomyocytes. [PDF]

Sci Rep, 2022
Takahashi H, Nagoshi T, Kimura H, Tanaka Y, Yasutake R, Oi Y, Yoshii A, Tanaka TD, Kashiwagi Y, Yoshimura M.   +9 more
europepmc   +1 more source

Redox Properties of 3-Iodothyronamine (T1AM) and 3-Iodothyroacetic Acid (TA1). [PDF]

Int J Mol Sci, 2022
Gencarelli M, Lodovici M, Bellusci L, Raimondi L, Laurino A.   +4 more
europepmc   +1 more source

Development and validation of an LC-MS/MS methodology for the quantification of thyroid hormones in dko MCT8/OATP1C1 mouse brain. [PDF]

J Pharm Biomed Anal, 2022
De Angelis M, Maity-Kumar G, Schriever SC, Kozlova EV, Müller TD, Pfluger PT, Curras-Collazo MC, Schramm KW.   +7 more
europepmc   +1 more source

Trace Amine-Associated Receptor 1 (TAAR1) Is a Positive Prognosticator for Epithelial Ovarian Cancer. [PDF]

Int J Mol Sci, 2021
Vogelsang TLR, Vattai A, Schmoeckel E, Kaltofen T, Chelariu-Raicu A, Zheng M, Mahner S, Mayr D, Jeschke U, Trillsch F.   +9 more
europepmc   +1 more source

Bilateral Shifts in Deuterium Supply Similarly Change Physiology of the Pituitary-Thyroid Axis, but Differentially Influence Na⁺/I^- Symporter Production. [PDF]

Int J Mol Sci, 2023
Yaglova NV, Obernikhin SS, Timokhina EP, Yaglov VV, Tsomartova DA, Nazimova SV, Tsomartova ES, Ivanova MY, Chereshneva EV, Lomanovskaya TA.   +9 more
europepmc   +1 more source