Results 31 to 40 of about 2,969 (182)
Developmentally Regulated Expression and Activity of Sulphotransferases in the Rat Choroid Plexuses
Journal of Neurochemistry, Volume 170, Issue 7, July 2026.The choroid plexus epithelium forms the blood–cerebrospinal fluid barrier, which plays a key role in regulating molecular exchange between blood circulation and brain. This study demonstrated that both sulphotransferase (SULT) enzymatic activity and the expression of Sult1a1 isoenzyme peaked in the rat choroid plexuses during the neonatal period ...
Fiona Qiu +3 more
wiley +1 more source
Advanced Healthcare Materials, Volume 15, Issue 24, 25 June 2026.A miniaturized drug sensitivity and resistance testing (DSRT) workflow based on the Droplet Microarray (DMA) platform enables functional drug testing using minimal patient‐derived tumor material. By screening nanoliter‐scale droplets containing as few as 300 cells, this approach generates reproducible and tumor‐specific drug response profiles ...
Maryam Salarian +7 more
wiley +1 more source
, 1976 The effects of overstimulation of the thyroid gland induced by the feeding of rapeseed meal or thiouracil during the growing period persisted for as long as 75 weeks after withdrawal of the source of goitrogen from the diet.
Peter Leung, B. E. March
core +1 more source
MedComm, Volume 7, Issue 6, June 2026.To define the mechanisms of sensitivity to PP2A inhibitors (PP2Ai), we combined molecular profiling of PP2Ai responses with genome‐wide genetic screens. PP2Ai preferentially target mesenchymal pancreatic ductal adenocarcinoma (PDAC) cells and engage pathways linked to transcriptional elongation, splicing, metabolism, and ER stress response factors ...
Janine Murr +37 more
wiley +1 more source
Relative activities of several 3'- and 3':5'-alkyl and aryl thyromimetic agents
, 1963 The biological activity of several 3:5-diiodo-3'- and 3':5'-alkyl and arylthyronines as well as of some 3:5-diiodo-3'-isopropylthyroacetic acid analogues was determined following their subcutaneous administration to adult male rats.
Benjamin Blank +3 more
core +1 more source
Photodegradable Hydrogels for On‐Demand Modeling of Age‐Related Spatiotemporal ECM Deformation
Small, Volume 22, Issue 27, 14 May 2026.A light‐tunable PEG hydrogel enables on‐demand, spatiotemporal modeling of drusen‐like ECM bulges in the aging outer retina. By precisely controlling bulge size, the platform reveals how retinal pigment epithelium morphology adapts to topographical changes without disrupting actin cytoskeleton or polarity, effectively mimicking early ageing before ...
Felix Reul +8 more
wiley +1 more source
Differential Effects of 3,5-Diiodo-L-Thyronine and 3,5,3’-Triiodo-L-Thyronine On Mitochondrial Respiratory Pathways in Liver from Hypothyroid Rats [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Both 3,5-diiodo-L-thyronine (3,5-T2) and 3,5,3’-triiodo-L-tyronine (T3) affect energy metabolism having mitochondria as a major target. However, the underlying mechanisms are poorly understood. Here, using a model of chemically induced hypothyroidism in male Wistar rats, we investigated the effect of administration of either 3,5-T2 or ...
Silvestri, Elena +9 more
openaire +5 more sources
Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth
Advanced Science, Volume 13, Issue 17, 23 March 2026.Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang +12 more
wiley +1 more source
Advanced Science, Volume 13, Issue 16, 18 March 2026.This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang +12 more
wiley +1 more source
Prostaglandin D2 Synthase Controls Schwann Cells Metabolism and Peripheral Myelin Homeostasis
Glia, Volume 74, Issue 3, March 2026.Prostaglandin D2 Synthase (L‐PGDS) controls PPNS myelin lipids’ composition and Schwann cells energetic metabolism In the absence of L‐PGDS Schwann cells turn to acetate as the main energetic source. These metabolic changes result in ketone bodies production to preserve neuronal survival.
Amelia Trimarco +16 more
wiley +1 more source