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New England Journal of Medicine, 1982
The modern era of neuroendocrinology was ushered in just over a decade ago with the isolation and characterization, from ovine1 and porcine2 hypothalamic tissue, of a tripeptide (pyroglutamyl-histi...
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The modern era of neuroendocrinology was ushered in just over a decade ago with the isolation and characterization, from ovine1 and porcine2 hypothalamic tissue, of a tripeptide (pyroglutamyl-histi...
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Thyrotropin-Releasing Hormone Analogs
Mini-Reviews in Medicinal Chemistry, 2006Thyrotropin releasing hormone (TRH: pyroglutamic acid-histidine-prolineamide) regulates the activity of cells in the anterior pituitary and within the central and peripheral nervous systems. TRH, which has been the subject of much research over the past three decades, exerts its effects by acting through class A G-protein coupled receptors.
A O, Colson, M C, Gershengorn
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Thyrotropin-releasing hormone in schizophrenia
American Journal of Psychiatry, 1975Oral administration of thyrotropin-releasing hormone (TRH) caused deterioration in the clinical status of seven out of nine schizophrenic men. This change was particularly apparent in the four patients diagnosed as paranoid schizophrenics. Such changes might be expected from a drug with properties similar to amphetamine.
K L, Davis, L E, Hossister, P A, Berger
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Thyrotropin-Releasing Hormone (TRH)
1995Over the past twenty years, alcoholism and alcohol abuse have been identified as behavioral disorders that arise from an interaction between genetic (biological) and experiential/environmental factors.1 As more is learned about alcoholism, it is clear that an indeterminate number of distinct and separate subgroups of the illness exist.1,2 Advances in ...
James C. Garbutt +2 more
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1985
Although the hypothalmic control of anterior pituitary function through endogenous chemical substances was postulated more than a generation ago, not until 1955 did the search begin for the hypothalamic release-modulating substances.1 Thyrotropin-releasing hormone (TRH) (Fig.
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Although the hypothalmic control of anterior pituitary function through endogenous chemical substances was postulated more than a generation ago, not until 1955 did the search begin for the hypothalamic release-modulating substances.1 Thyrotropin-releasing hormone (TRH) (Fig.
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Pharrnacokinetics of intrathecal thyrotropinâreleasing hormone
Neurology, 1987An investigation of the efficacy of thyrotropin-releasing hormone in amyotrophic lateral sclerosis included study of the intrathecal pharmacokinetics of this neuropeptide. Its mean elimination half-life in CSF was 0.90 hours and was monoexponential. During a 2-hour infusion, 2.75% crossed the CSF/blood-brain barrier.
T L, Munsat, J, Taft, I M, Jackson
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Organ distribution of thyrotropin-releasing hormone
General and Comparative Endocrinology, 1972Abstract The distribution of radioactivity after intravenous injection of [ 3 H]- or [ 14 C]thyrotropin-releasing hormone has been studied by whole-body autoradiography of the mouse or direct measurement of radioactivity in individual organs of the rat. Data obtained with the two different techniques and animal species are in good agreement.
A, Dupont +3 more
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