Results 151 to 160 of about 37,327 (207)

Influence of thyrotropin-free serum on the radioimmunoassay of human thyrotropin

Clinica Chimica Acta, 1973
Abstract The addition of thyrotropin-free serum to the reagents of the standard curve modifies the results of thyrotropin measurements in human serum. This modification, related to a decrease in the antibody-bound labelled human thyrotropin and to a shift to the left of the standard curve, varies greatly according to the anti-human thyrotropin ...
Golstein Golaire, Jacqueline, Vanhaelst, Luc   +1 more
openaire   +3 more sources

Thyrotropin secretion before and after ovariectomy in premenopausal women

Gynecological Endocrinology, 1993
Many studies have shown a physiological reduction in thyroid function with age in animals, and less clearly in humans, with an increase in the incidence of age-dependent clinical and subclinical hypothyroidism.
Vincenzo de Leo
exaly   +2 more sources

The Thyrotropin Receptor

1995
This chapter has outlined the complex process required for thyroid growth and function. Both events are regulated by TSHR via a multiplicity of signals, with the aid of and requirement for a multiplicity of hormones that regulate the TSHR via receptor cross-talk: insulin, IGF-I, adrenergic receptors, and purinergic receptors.
L. D. Kohn, H. Shimura, Y. Shimura, A. Hidaka, GIULIANI, Cesidio, NAPOLITANO, Giorgio, M. Ohmori, G. Laglia, M. Saji   +8 more
openaire   +3 more sources

Resistance to thyrotropin

Journal of Endocrinological Investigation, 2003
Resistance to TSH is a syndrome of reduced sensitivity to a biologically active TSH molecule. Subjects have elevated TSH levels but no goiter. However, thyroid hormone concentration may vary from normal to very high, depending on the severity of the resistance.
openaire   +2 more sources

Thyrotropin and Thyrotropin-Releasing Hormone

1987
Pituitary thyrotropin, or thyroid-stimulating hormone (TSH), as the name implies, is the principal regulator that governs the growth and function of the thyroid gland. The secretion, metabolism, regulatory control, and actions of this important glycoprotein form the basis of this chapter.
openaire   +1 more source

Analysis of the Thyrotropin Receptor-Thyrotropin Interaction by Comparative Modeling

Thyroid, 2004
We have used the most advanced programs currently available to construct the first three-domain structure of the human thyrotropin receptor (TSHR) using comparative modeling. The model consists of a leucine-rich domain (LRD; amino acids 36-281; porcine ribonuclease inhibitor used as a template for modeling), a cleavage domain (CD; amino acids 282-409 ...
Ricardo, Núñez Miguel, Jane, Sanders, Jennifer, Jeffreys, Hilde, Depraetere, Michele, Evans, Tonya, Richards, Tom L, Blundell, Bernard, Rees Smith, Jadwiga, Furmaniak   +8 more
openaire   +2 more sources

POSITIVE REGULATION OF HUMAN THYROTROPIN RECEPTOR mRNA BY THYROTROPIN

The Journal of Clinical Endocrinology & Metabolism, 1991
We have assessed the influence of natural and recombinant thyrotropin (TSH) on mRNA specific for the human TSH receptor (TSHR) in normal and abnormal adult human thyroid monolayer cells. Using physiological concentrations of TSH (less than 100 mU/L), a marked increase in the level of TSHR mRNA was observed within 12 hours and reached a greater than ...
G K, Huber, E S, Concepcion, P N, Graves, T F, Davies   +3 more
openaire   +2 more sources

Cleavage of the human thyrotropin receptor by ADAM10 is regulated by thyrotropin

Journal of Molecular Recognition, 2007
AbstractThe thyrotropin receptor (TSHR) has a unique 50 residue (317–366) ectodomain insertion that sets it apart from other glycoprotein hormone receptors (GPHRs). Other ancient members of the leucine‐rich repeat G protein‐coupled receptor (GPCR) (LGR) family do exhibit ectodomain insertions of variable lengths and sequences.
Viktoria, Kaczur, Laszlo G, Puskas, Zsuzsanna U, Nagy, Nabil, Miled, Ahmed, Rebai, Ferenc, Juhasz, Zoltan, Kupihar, Agnes, Zvara, Laszlo, Hackler, Nadir R, Farid   +9 more
openaire   +2 more sources

Binding of thyrotropin releasing hormone by thyrotropin-secreting cells

Biochemical and Biophysical Research Communications, 1973
Abstract In order to localize and identify receptor structures, the binding of radiolabeled thyrotropin releasing hormone (TRH) to thyrotropin (TSH)-secreting cells from rat and bovine anterior pituitaries and from a mouse TSH-secreting tumor was studied in vitro . The binding of TRH to rat anterior pituitaries increased linearly with the log of
Eddy, L J, Hershman, J M, Taylor, R E, Barker, S B   +3 more
openaire   +2 more sources

Comparison of Recombinant Human Thyrotropin Receptors Versus Porcine Thyrotropin Receptors in the Thyrotropin Binding Inhibition Assay for Thyrotropin Receptor Autoantibodies

Thyroid, 1999
Thyrotropin receptor autoantibodies (TRAb) are most commonly measured in a thyrotropin-binding inhibition (TBI) assay using solubilized porcine thyrotropin receptors (pTSHR). Recently, we reported modifications in recombinant human thyrotropin receptor (hTSHR) production and extraction that made substitution of this antigen for the pTSHR practical.
A, Kakinuma, I, Morimoto, T, Kuroda, T, Fujihira, S, Eto, S M, McLachlan, B, Rapoport   +6 more
openaire   +2 more sources