The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target? [PDF]
Frontiers in Pharmacology, 2020 Thyrotropin releasing hormone (TRH: Glp-His-Pro-NH2) is a peptide mainly produced by brain neurons. In mammals, hypophysiotropic TRH neurons of the paraventricular nucleus of the hypothalamus integrate metabolic information and drive the secretion of ...
Jean-Louis Charli +6 more
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Thyrotropin-Releasing Hormone for Cerebellar Ataxia
Pediatric Neurology Briefs, 1989 A nine year old girl with cerebel lar ataxia that responded to thyrotropin-releasing hormone is reported from the Department of Pediatrics, Kyoto Prefectero University of Medicine, Kyoto, Japan.
J Gordon Millichap
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Efficiency of CIN2+ Detection by Thyrotropin-Releasing Hormone (TRH) Site-Specific Methylation [PDF]
Viruses, 2023 Cervical cancer screening typically involves a Pap smear combined with high-risk human papillomavirus (hr-HPV) detection. Women with hr-HPV positivity but normal cytology, as well as those with precancerous abnormal cytology, such as low-grade squamous ...
Arkom Chaiwongkot +4 more
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Journal of Medical Case Reports, 2011 Introduction While thyrotropin-releasing hormone is known to be a prolactin-release stimulating factor, thyrotropin-releasing hormone-tartrate and its derivative, taltirelin hydrate, are used for the treatment of spinocerebellar degeneration, a ...
Kanasaki Haruhiko +4 more
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Thyrotropin-Releasing Hormone and Food Intake in Mammals: An Update [PDF]
MetabolitesThyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2) is an intercellular signal produced mainly by neurons. Among the multiple pharmacological effects of TRH, that on food intake is not well understood.
Yamili Vargas +5 more
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Thyrotropin-releasing hormone neurons of different hypothalamic nuclei increase energy expenditure [PDF]
Nature CommunicationsSeveral neuronal populations in the hypothalamus and brainstem express thyrotropin-releasing hormone (TRH). While TRH neurons in the paraventricular nucleus (PVN) regulate the thyroid axis, the roles of other TRH-producing neurons remain largely unknown.
Andreea Constantinescu +18 more
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Characterization of a novel thyrotropin-releasing hormone receptor, TRHR3, in chickens [PDF]
Poultry Science, 2020 The physiological roles of thyrotropin-releasing hormone (TRH) are proposed to be mediated by TRH receptors (TRHR), which have been divided into 3 subtypes, namely, TRHR1, TRHR2, and TRHR3, in vertebrates.
Xiaoxiao Li +5 more
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Repeatability of a thyrotropin‐releasing hormone stimulation test for diagnosis of pituitary pars intermedia dysfunction in mature horses [PDF]
Journal of Veterinary Internal Medicine, 2021 Background Pituitary pars intermedia dysfunction (PPID) is a common endocrinopathy of horses diagnosed with a thyrotropin‐releasing hormone (TRH) stimulation test.
Yan Ning Kam +3 more
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Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach [PDF]
Pharmaceutics, 2019 Using thyrotropin-releasing hormone (TRH) as a model, we explored whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery ...
Katalin Prokai-Tatrai +5 more
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Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries [PDF]
Frontiers in Endocrinology, 2019 Central and peripheral mechanisms that modulate energy intake, partition and expenditure determine energy homeostasis. Thyroid hormones (TH) regulate energy expenditure through the control of basal metabolic rate and thermogenesis; they also modulate ...
Adair Rodríguez-Rodríguez +6 more
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