Results 1 to 10 of about 300 (115)
The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target?
Frontiers in Pharmacology, 2020 Thyrotropin releasing hormone (TRH: Glp-His-Pro-NH2) is a peptide mainly produced by brain neurons. In mammals, hypophysiotropic TRH neurons of the paraventricular nucleus of the hypothalamus integrate metabolic information and drive the secretion of ...
Jean-Louis Charli +6 more
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The Ups and Downs of Thyrotropin-Releasing Hormone [PDF]
Endocrinology, 2009 The synthesis and secretion of thyrotropin-releasing hormone (TRH) is absolutely required for intact thyroid function in humans and rodents. Furthermore, feedback regulation of TRH production by thyroid hormone allows for tight maintenance of circulating thyroid hormone levels and thus establishes the hypothalamic-pituitary-thyroid (H-P-T) axis ...
Anthony Hollenberg
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Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries
Frontiers in Endocrinology, 2019 Central and peripheral mechanisms that modulate energy intake, partition and expenditure determine energy homeostasis. Thyroid hormones (TH) regulate energy expenditure through the control of basal metabolic rate and thermogenesis; they also modulate ...
Adair Rodríguez-Rodríguez +6 more
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Role of the thyrotropin-releasing hormone of the limbic system in mood and eating regulation
Journal of Integrative Neuroscience, 2022 Thyrotropin-releasing hormone (TRH) and its receptors are expressed in the hypothalamus and limbic regions. Brain thyrotropin-releasing hormone actions are exerted directly through its receptors and indirectly by modulating the effects of ...
Elena Alvarez-Salas +3 more
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Receptor modulators associated with the hypothalamus -pituitary-thyroid axis
Frontiers in Pharmacology, 2023 The hypothalamus-pituitary-thyroid (HPT) axis maintains normal metabolic balance and homeostasis in the human body through positive and negative feedback regulation.
Xianbin Cheng +7 more
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Effects of arsenic exposure on E2 and TRH and their receptor mRNA expressions in rats
环境与职业医学, 2023 BackgroundArsenic can enter the hypothalamus to induce estrogen effect and interfere with the function of the neuroendocrine system. The thyroid endocrine system (hypothalamic-pituitary-thyroid axis) is one of the main endocrine systems, and the ...
Yuanyan LAI +4 more
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Frontiers in Endocrinology, 2021 The adenohypophysis contains five secretory cell types (somatotrophs, lactotrophs, thyrotrophs, corticotrophs, and gonadotrophs), each secreting a different hormone, and controlled by different hypothalamic releasing hormones (HRHs).
Jonathan Rojo-Ruiz +4 more
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Sexually dimorphic dynamics of thyroid axis activity during fasting in rats
Frontiers in Bioscience-Landmark, 2020 Starvation induces tertiary hypothyroidism in adult rodents. Response of the hypothalamus-pituitary-thyroid (HPT) axis to starvation is stronger in adult males than in females.
Patricia Joseph-Bravo +6 more
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GATA2 mediates thyrotropin-releasing hormone-induced transcriptional activation of the thyrotropin β gene. [PDF]
PLoS ONE, 2011 Thyrotropin-releasing hormone (TRH) activates not only the secretion of thyrotropin (TSH) but also the transcription of TSHβ and α-glycoprotein (αGSU) subunit genes.
Kenji Ohba +9 more
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Journal of Medical Case Reports, 2011 Introduction While thyrotropin-releasing hormone is known to be a prolactin-release stimulating factor, thyrotropin-releasing hormone-tartrate and its derivative, taltirelin hydrate, are used for the treatment of spinocerebellar degeneration, a ...
Kanasaki Haruhiko +4 more
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