The Thyrotropin-Releasing Hormone-Degrading Ectoenzyme, a Therapeutic Target? [PDF]
Frontiers in Pharmacology, 2020 Thyrotropin releasing hormone (TRH: Glp-His-Pro-NH2) is a peptide mainly produced by brain neurons. In mammals, hypophysiotropic TRH neurons of the paraventricular nucleus of the hypothalamus integrate metabolic information and drive the secretion of ...
Jean-Louis Charli +6 more
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Efficiency of CIN2+ Detection by Thyrotropin-Releasing Hormone (TRH) Site-Specific Methylation [PDF]
Viruses, 2023 Cervical cancer screening typically involves a Pap smear combined with high-risk human papillomavirus (hr-HPV) detection. Women with hr-HPV positivity but normal cytology, as well as those with precancerous abnormal cytology, such as low-grade squamous ...
Arkom Chaiwongkot +4 more
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Thyrotropin-Releasing Hormone and Food Intake in Mammals: An Update [PDF]
MetabolitesThyrotropin-releasing hormone (TRH; pGlu-His-Pro-NH2) is an intercellular signal produced mainly by neurons. Among the multiple pharmacological effects of TRH, that on food intake is not well understood.
Yamili Vargas +5 more
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Thyrotropin-releasing hormone neurons of different hypothalamic nuclei increase energy expenditure [PDF]
Nature CommunicationsSeveral neuronal populations in the hypothalamus and brainstem express thyrotropin-releasing hormone (TRH). While TRH neurons in the paraventricular nucleus (PVN) regulate the thyroid axis, the roles of other TRH-producing neurons remain largely unknown.
Andreea Constantinescu +18 more
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The Ups and Downs of Thyrotropin-Releasing Hormone [PDF]
Endocrinology, 2009 The synthesis and secretion of thyrotropin-releasing hormone (TRH) is absolutely required for intact thyroid function in humans and rodents. Furthermore, feedback regulation of TRH production by thyroid hormone allows for tight maintenance of circulating thyroid hormone levels and thus establishes the hypothalamic-pituitary-thyroid (H-P-T) axis ...
Anthony Hollenberg +1 more
exaly +3 more sources
Characterization of a novel thyrotropin-releasing hormone receptor, TRHR3, in chickens [PDF]
Poultry Science, 2020 The physiological roles of thyrotropin-releasing hormone (TRH) are proposed to be mediated by TRH receptors (TRHR), which have been divided into 3 subtypes, namely, TRHR1, TRHR2, and TRHR3, in vertebrates.
Xiaoxiao Li +5 more
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Brain Delivery of Thyrotropin-Releasing Hormone via a Novel Prodrug Approach [PDF]
Pharmaceutics, 2019 Using thyrotropin-releasing hormone (TRH) as a model, we explored whether synergistic combination of lipoamino acid(s) and a linker cleaved by prolyl oligopeptidase (POP) can be used as a promoiety for prodrug design for the preferential brain delivery ...
Katalin Prokai-Tatrai +5 more
doaj +2 more sources
Molecular basis for the activation of thyrotropin-releasing hormone receptor [PDF]
Cell Discovery, 2022 Su-Yu Ji +13 more
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Tanycytes and the Control of Thyrotropin-Releasing Hormone Flux Into Portal Capillaries [PDF]
Frontiers in Endocrinology, 2019 Central and peripheral mechanisms that modulate energy intake, partition and expenditure determine energy homeostasis. Thyroid hormones (TH) regulate energy expenditure through the control of basal metabolic rate and thermogenesis; they also modulate ...
Adair Rodríguez-Rodríguez +6 more
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Contribution of Thyrotropin-Releasing Hormone to Cerebellar Long-Term Depression and Motor Learning [PDF]
Frontiers in Cellular Neuroscience, 2018 Thyrotropin-releasing hormone (TRH) regulates various physiological activities through activation of receptors expressed in a broad range of cells in the central nervous system.
Masashi Watanave +6 more
doaj +2 more sources