Results 41 to 50 of about 484,531 (179)

Incidence and Predictors of Immune‐Related Hypothyroidism Under Pembrolizumab Across Gynecologic Malignancies and Melanoma: A Real‐World Cohort Study

International Journal of Cancer, EarlyView.
ABSTRACT Immune checkpoint inhibitors (ICIs) frequently cause thyroid immune‐related adverse events (irAEs). Permanent hypothyroidism, the clinically most relevant phenotype, requires lifelong hormone replacement. We investigated its incidence, course, risk factors, and prognostic relevance under pembrolizumab.
Freya Koffka, Johann Kornowski, Elena Laakmann, Barbara Schmalfeldt, Tim Zell, Glenn Geidel, Christoffer Gebhardt, Pia Roser, Volkmar Müller, Julian Kött   +9 more
wiley   +1 more source

Neurotensin-induced antinociception in mice: antagonism by thyrotropin-releasing hormone

, 1981
Neurotensin (NT), administered intracisternally to mice, produced significant dose-dependent antinociception in three analgesic tests: tail immersion, hot-plate and acetic acid writhing. Naloxone (1-5 mg/kg), an opiate antagonist administered i.p. 20 min
Nemeroff, C B, Luttinger, D, Mason, G A, Osbahr, 3rd, A J, Prange, Jr, A J   +4 more
core   +3 more sources

Studying Periostin as a Diagnostic Marker in Sera of Iraqi Patients Hypothyroidism

Ibn Al-Haitham Journal for Pure and Applied Sciences
Hypothyroidism is one of the most common thyroid diseases in adults. Hypothyroidism is a condition that results from a deficiency of thyroid hormone and can range from being asymptomatic to life-threatening.
Duha Khalil Ibrahim, Layla Othman Farhan
doaj   +1 more source

Transcriptomic identification of starfish neuropeptide precursors yields new insights into neuropeptide evolution [PDF]

Open Biology, 2016
Neuropeptides are evolutionarily ancient mediators of neuronal signalling in nervous systems. With recent advances in genomics/transcriptomics, an increasingly wide range of species has become accessible for molecular analysis.
Dean C. Semmens, Olivier Mirabeau, Ismail Moghul, Mahesh R. Pancholi, Yannick Wurm, Maurice R. Elphick   +5 more
doaj   +1 more source

Hormone therapy (HT) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto, Suvarna S. Khadilkar, Rossella E. Nappi, Andrea R. Genazzani, Federica Frezet, Laura Cucinella, Hema Divakar, Panagiotis Anagnostis, Nick Panay   +8 more
wiley   +1 more source

Effects of Thyrotropin-Releasing Hormone in Depression [PDF]

, 1972
Ten euthyroid women with unipolar depression were treated with a single injection of thyrotropin-releasing hormone (T.R.H.) and a single injection of saline in a double-blind, crossover comparison. T.R.H.
Prange, A.J., Jr., Alltop, L.B., Wilson, I.C., Lara, P.P., Breese, George R.   +4 more
core   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Afferent Neuronal Control of Type-I Gonadotropin Releasing Hormone Neurons in the Human. [PDF]

, 2013
Understanding the regulation of the human menstrual cycle represents an important ultimate challenge of reproductive neuroendocrine research. However, direct translation of information from laboratory animal experiments to the human is often complicated ...
Zsolt Liposits, Hrabovszky, Erik, Liposits, Zsolt, Erik Hrabovszky   +3 more
core   +1 more source

Roxadustat and transfusional iron overload induced hypothyroidism in a hemodialysis patient: a case report with a literature review

Renal Replacement Therapy
Background Although roxadustat has been reported to cause central hypothyroidism, the details of the mechanisms and clinical characteristics of patients who are prone to developing hypothyroidism with roxadustat are uncertain. Case presentation A 53-year-
Chikako Yamashita, Yuri Hirai, Toshiya Nishigaito, Kensuke Mitsumoto, Aya Mizumoto, Manabu Kawakami, Takashi Uzu   +6 more
doaj   +1 more source

Dampak Klinis Thyroid-Stimulating Hormone

Jurnal Kesehatan Andalas, 2017
Thyroid-Stimulating Hormone (TSH), yang disebut juga dengan tirotropin, adalah glikoprotein yang disekresikan oleh bagian anterior dari kelenjar hipofisis. Sintesis dan sekresi dari TSH diatur oleh faktor dari hipotalamus yang didominasi oleh thyrotropin-
Eva Decroli, Alexander Kam
doaj   +1 more source