Results 61 to 70 of about 537,941 (229)

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor

Frontiers in Endocrinology, 2012
Taltirelin (TAL) is a thyrotropin-releasing hormone (TRH) analog that is approved for use in humans in Japan. In this study, we characterized TAL binding to and signaling by the human TRH receptor (TRH-R) in a model cell system.
Nanthakumar eThirunarayanan, Bruce M. Raaka, Marvin C Gershengorn   +2 more
doaj   +1 more source

Thyrotropinoma - the case report about one of the rarest type of pituitary adenomas

Journal of Education, Health and Sport, 2022
Pituitary tumours are a significant diagnostic problem in clinical practice. Considering all the rarity of thyrotropic hormone secreting adenoma it is a diagnostic and therapeutic challenge in part due to the lack of the preoperative standards. TSH-oma,
Piotr Michał Jarosz, Zuzanna Idzik, Jakub Gołacki, Ewa Obel   +3 more
doaj   +1 more source

Intersection of systemic lupus erythematosus and autoimmune thyroid disease: Shared pathophysiology, epidemiology, diagnosis, and management

Rheumatology &Autoimmunity, EarlyView.
A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa, Awalia Awalia, Deasy Ardiany, Henry Sutanto   +3 more
wiley   +1 more source

Investigation of Responsiveness to Thyrotropin-Releasing Hormone in Growth Hormone-Producing Pituitary Adenomas

International Journal of Endocrinology, 2013
Objective. The aim of this study was to investigate how the paradoxical response of GH secretion to TRH changes according to tumor volumes. Methods.
Sang Ouk Chin, Sang Youl Rhee, Suk Chon, You-Cheol Hwang, In-Kyung Jeong, Seungjoon Oh, Sung-Woon Kim   +6 more
doaj   +1 more source

Clinical implications of using adrenocorticotropic hormone diagnostic cutoffs or reference intervals to diagnose pituitary pars intermedia dysfunction in mature horses

Journal of Veterinary Internal Medicine, 2021
Background Diagnosis of pituitary pars intermedia dysfunction (PPID) is problematic because of large variations in ACTH concentrations. Hypothesis/Objectives Compare the test characteristics of baseline and post–thyrotropin‐releasing hormone (TRH ...
Remona Horn, Allison J. Stewart, Karen V. Jackson, Elizabeth L. Dryburgh, Carlos E. Medina‐Torres, François‐René Bertin   +5 more
doaj   +1 more source

Australian collaborative trial of antenatal thyrotropin-releasing hormone: adverse effects at 12-month follow-up

, 1997
Reports a 12-month follow up of the health and development of the children entered into the Australian Collaborative Trial of Antenatal Thyrotropin-Releasing Hormone (ACTOBAT).
Smith, D, HendersonSmart, D, Peres, M, Leslie, G, Ballesty, J, Arnold, J, Child, A, Crowther, C., Edwards, D, Haslam, R., Rowley, M, Nicholl, M, Reynolds, G, Robinson, J., Chin, M, Cook, C, Garvey, P, Gill, A, Evans, C, Walters, W, Downe, L, John, E, Likeman, R, Crowther, CA, Haslam, RR, Hiller, J., Hiller, JE, Fisher, C, Trudinger, B, Roberts, S, Chiltern, H, Giles, W, Robinson, JS, Ellwood, D, Pesce, A   +34 more
core   +1 more source

Microplastics and the Endocrine–Metabolic Interface: Novel Diagnostic Tools Targeting Thyroid–Adipose Axis

Environmental Toxicology, EarlyView.
ABSTRACT Microplastics (MPs) have been identified as major environmental contaminants that can affect organisms directly and act as carriers of particles and chemical additives, thereby aggravating endocrine networks that coordinate metabolic homeostasis.
Sunday Amos Onikanni, Babasola Aiyeku, Marjorie Dardis Murucci, Temitope Aribigbola, Kenia Bispo, Oluwatosin Stella Olayinka, Rômulo Sperduto Dezonne, Sara Gemini Piperni, Paula Soares, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

From Consumer Plastics to Aquatic Toxicants: Oxidative and Endocrine Effects of Microplastics on Fathead Minnow (Pimephales promelas) Larvae

Environmental Toxicology, EarlyView.
ABSTRACT Secondary microplastics (MPs) from single‐use consumer products are rapidly becoming one of the most persistent and widespread pollutants of our time. Freshwater systems act as early sinks for MPs where fragmentation and additive leaching expose aquatic life to a broad spectrum of toxic compounds.
Alisha M. Janiga‐MacNelly, Andrew Barrick, Tham C. Hoang, Ramon Lavado   +3 more
wiley   +1 more source

The 5T Paradox of Triclosan: From Toiletries to Toxic Trash, a Growing Threat to Humanity

Environmental Toxicology, EarlyView.
ABSTRACT Triclosan (TCS) persists as a contaminant of concern in the Anthropocene, despite regulatory actions. Environmental dissemination continues through wastewater effluents, biosolid application, and improper disposal practices. This narrative review synthesizes current evidence regarding triclosan's environmental fate, transformation pathways ...
Temitope Aribigbola, Mauro Ricardo Souza da Luz, Sunday Amos Onikanni, Marjorie Dardis Murucci, Oluwatosin Stella Olayinka, Rodrigo Soares Fortunato, Rômulo Sperduto Dezonne, Omolola Esther Amos, Sara Gemini Piperni, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source