Results 61 to 70 of about 13,578 (179)

Multi‐Omics‐Guided Design and Safety Engineering of Nucleic Acid Therapeutics: From Molecular Perturbation to Predictive Toxicology and Precision Translation

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Multi‐omics (proteomics, metabolomics, and single‐cell/spatial transcriptomics) provides a systems framework to distinguish on‐target efficacy from off‐target and toxicity signatures of chemically modified nucleic acid therapeutics, enabling omics‐guided structure–activity and safety optimisation from discovery to clinical translation. ABSTRACT Nucleic
Gurjit Kaur Bhatti, Anushka Verma, Komal Devi, Naina Khullar, Inderpal Singh Sidhu, Umesh Chand Singh Yadav, Jasvinder Singh Bhatti   +6 more
wiley   +1 more source

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, Volume 293, Issue 15, Page 4680-4703, August 2026.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

Testing for a causal role of thyroid hormone measurements within the normal range on human metabolism and diseases: a systematic Mendelian randomizationResearch in context

EBioMedicine
Summary: Background: Variation in thyroid function parameters within the normal range has been observationally associated with adverse health outcomes. Whether those associations reflect causal effects is largely unknown.
Heba Alwan, Jian'an Luan, Alice Williamson, Julia Carrasco-Zanini, Isobel D. Stewart, Nicholas J. Wareham, Claudia Langenberg, Maik Pietzner   +7 more
doaj   +1 more source

The Significance of the Regulation Between tRF‐31‐U5YKFN8DYDZDD and BMPER in the Pathogenesis of Gastric Cancer (GC)

Journal of Cellular and Molecular Medicine, Volume 30, Issue 16, August 2026.
ABSTRACT tsRNAs are a kind of small non‐coding single‐stranded RNA, which play an important role in many kinds of tumours. Previous studies have identified that tRF‐31‐U5YKFN8DYDZDD can be used as a novel tumour biomarker for the diagnosis and prognosis of gastric cancer (GC).
Yuejiao Huang, Xun Li, Yu Zhang, Xinliang Gu, Shiyi Qin, Ming Zheng, Han Wang, Shaoqing Ju   +7 more
wiley   +1 more source

Rapid determination of thyroxine binding proteins of human serum.

Acta medica Okayama, 1976
A simple method is described for determing thyroxine binding proteins in human serum by electrophoresis at pH 8.6, using cellulose acetate membrane as the supporting medium. The procedure had high reliability in sera of normal subjects, pregnant women and patients with decreased thyroxine binding capacity of thyroxine binding globulin.
Arima, Terukatsu, Takata, Shinji, Imai, Masanobu, Kondo, Tadasuke, Kosaka, Kiyowo   +4 more
openaire   +3 more sources

Thyroxine binding by serum proteins

The Journal of Physiology, 1960
W E, BALFOUR, H E, TUNNICLIFFE
openaire   +3 more sources

<i>Withania somnifera</i> Root Extract Ameliorates PTU-Induced Hypothyroidism by Regulating Hormone Levels and Gene Expression in Rats. [PDF]

Food Sci Nutr
Hossain MS, Shuvo MSP, Talukder MMH, Shahidullah, Jannat S, Niaz SMR, Sohel M, Islam MK.   +7 more
europepmc   +1 more source

The Thyroxine-binding Protein of Bovine Synovial Fluid

Journal of Biological Chemistry, 1959
O W, NEUHAUS, V, SOGOIAN
openaire   +2 more sources

Validation of Immunoassays for Total Thyroxine and Free Thyroxine and Age and Sex-Related Variation in Thyroid Hormone Serum Concentrations in Orangutans (Pongo sp.). [PDF]

J Med Primatol
Fayette MA, Moresco A, Bassiouny E, Agnew DW, Petroff B.   +4 more
europepmc   +1 more source

Ultrasensitive Label-Free Detection of Free Thyroxine (T4) in Physiological Ranges Using Aptamer-Functionalized Silicon Nanowire Field Effect Transistors. [PDF]

Biosensors (Basel)
Klinghammer S, Butko W, Parichenko A, Kastrati G, Kastrati G, Herbawi A, Riemenschneider L, Cuniberti G.   +7 more
europepmc   +1 more source