Results 41 to 50 of about 77,852 (275)

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Genetic and population analyses implicate thyroid‐related regulation of RNF144B in chondrocalcinosis

Arthritis &Rheumatology, Accepted Article.
Objectives Chondrocalcinosis, characterized by calcium crystal deposition within articular cartilage, affects 5–15% of the general population and has recently been identified as an osteoarthritis risk factor. However, Its biological pathways remain unclear.
Yahong Wu, Yanning Xu, Paul C. Okoro, Sirine Saafi, Jard de Vries, Xiaoyi Qi, Edwin H.G. Oei, Sita Bierma‐Zeinstra, Trudy Voortman, David Felson, Joyce BJ van Meurs, Layal Chaker, J. Mark Wilkinson, Michelle S. Yau, Jessica Bertrand, Cindy G. Boer   +15 more
wiley   +1 more source

Review of the risks and/or benefits of thyroxine treatment in ‘mild’ subclinical hypothyroidism [PDF]

, 2013
Subclinical hypothyroidism (SCH) is a form of mild thyroid failure and is a commonly encountered condition in clinical practice. It denotes the presence of a raised serum thyroid stimulating hormone (TSH) and normal serum free thyroid hormone ...
Agius, Rachel
core  

Isolated thyroxine malabsorption treated with intramuscular thyroxine injections

, 2009
An 18-year-old girl with multiple autoimmune endocrinopathies was referred to the endocrinology clinic for management of hypothyroidism. She required increasing doses of thyroxine but remained hypothyroid.
Anderson, Lydia, Patel, Vinod, Goenka, Niru, Joseph, Franklin   +3 more
core   +1 more source

Thyroglobulin as an evolving biomarker of iodine reserve in thyroid dysfunction assessment in pregnancy

Nigerian Journal of Medicine, 2022
Background: Despite the use of routine thyroid function tests, thyroid dysfunction is often missed in pregnant women, who may have fluctuating iodine reserves and this may be associated with an increased risk of adverse maternal and fetal outcomes due to
Terry Terfa Gbaa
doaj   +1 more source

Status and future of recombinant adeno‐associated virus vector manufacturing

Biotechnology Progress, EarlyView.
Abstract Sixty years of adeno‐associated virus (AAV) research illustrates a trajectory marked by basic science exploration, iterative innovation, persistent challenges, a number of clinical setbacks, as well as commercial therapeutic triumphs. This continual evolution has led to recombinant AAV (rAAV) becoming a cornerstone of modern gene therapy ...
Frank Agbogbo, David Dismuke
wiley   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Unforeseen Effect of Thyroxine Binding Globulin when Using the Microencapsulated Antibody Method to Determine Free Thyroxine (FT4): Misleading Results Due to Circulating Unsaturated Thyroxine Binding Globulin [PDF]

, 1989
Summary: The effect of varying concentrations (0 — 52 mg/1) of purified thyroxine binding globulin (TBG) on the microencapsulated antibody method for free thyroxine was investigated.
Nagahara, Mikio, Matsubara, Fujitsugu, Fujitsugu Matsubara, Hashimoto, Takuma, Mikio Nagahara, Takuma Hashimoto, Kaichiro Ishibashi, Ishibashi, Kaichiro   +7 more
core   +1 more source

Physiological-biochemical status of perch (Perca fluviatilis Linnaeus, 1758) and roach in conditions (Rutilus rutilus Linnaeus, 1758) of excessive anthropogenic pressure on the body of water

Ribogospodarsʹka Nauka Ukraïni, 2017
Purpose. To establish during the spring and summer period the physiologically-biochemical response of fish to the effect of excessive anthropogenic contamination on the indicators of the maintenance of hormones and glucose in their blood plasma, and the ...
V. Martseniuk, A. Potrokhov, O. Zinkovskyi, M. Prichepa   +3 more
doaj   +1 more source

A phenomap of TTR amyloidosis to aid diagnostic screening

ESC Heart Failure, Volume 12, Issue 2, Page 1113-1118, April 2025.
Abstract Cardiac amyloidosis due to transthyretin (ATTR) remains an underdiagnosed cause of cardiomyopathy. As awareness of the disease grows and referrals for ATTR increase, clinicians are likely to encounter more atypical forms of the condition in clinical practice.
Alexios S. Antonopoulos, Theodoros Tsampras, George Lazaros, Konstantinos Tsioufis, Charalambos Vlachopoulos   +4 more
wiley   +1 more source