Results 61 to 70 of about 77,852 (275)

Incidence and Predictors of Immune‐Related Hypothyroidism Under Pembrolizumab Across Gynecologic Malignancies and Melanoma: A Real‐World Cohort Study

International Journal of Cancer, EarlyView.
ABSTRACT Immune checkpoint inhibitors (ICIs) frequently cause thyroid immune‐related adverse events (irAEs). Permanent hypothyroidism, the clinically most relevant phenotype, requires lifelong hormone replacement. We investigated its incidence, course, risk factors, and prognostic relevance under pembrolizumab.
Freya Koffka, Johann Kornowski, Elena Laakmann, Barbara Schmalfeldt, Tim Zell, Glenn Geidel, Christoffer Gebhardt, Pia Roser, Volkmar Müller, Julian Kött   +9 more
wiley   +1 more source

Prevalence of Residual Symptoms Following Thyroid-Stimulating Hormone Normalization in Patients with Hypothyroidism [PDF]

مجله دانشگاه علوم پزشکی گرگان
Background and Objective: Hypothyroidism is a clinical syndrome resulting from a deficiency in thyroid hormone production. Despite achieving normalized thyroid-stimulating hormone (TSH) levels through levothyroxine (LT4) therapy, many patients continue ...
Seyed Mohammad Aria, Maryam Zahedi, Fatemeh Mohmmadzade, Alireza Seyedi Niaki, Somayeh Ghorbai   +4 more
doaj  

The diagnosis and management of central hypothyroidism in 2018

Endocrine Connections, 2019
Central hypothyrodism (CeH) is a hypothyroid state caused by an insufficient stimulation by thyrotropin (TSH) of an otherwise normal thyroid gland.
Luca Persani, Biagio Cangiano, Marco Bonomi   +2 more
doaj   +1 more source

Hormone therapy (HT) in women with premature ovarian insufficiency or early menopause: Time to think of a new paradigm for healthy aging. A joint FIGO and IMS position paper

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Premature ovarian insufficiency (POI) and early menopause (EM) affect millions of women worldwide. Compared with normal menopause, they confer a longer duration of estrogen deficiency and are associated not only with a shorter lifespan, but with a reduced healthspan, owing to an increased risk of cardiovascular, skeletal, cognitive and ...
Chiara Benedetto, Suvarna S. Khadilkar, Rossella E. Nappi, Andrea R. Genazzani, Federica Frezet, Laura Cucinella, Hema Divakar, Panagiotis Anagnostis, Nick Panay   +8 more
wiley   +1 more source

Thyroxine and wool follicle activity

, 1979
Serum thyroxine levels were observed in 15 Soay ewes and seven rams for 1 year. From June to November the ewes had thyroxine concentrations 40% higher than the rams, and the level in both sexes increased from December to May, demonstrating a seasonal ...
M. L. Ryder
core   +1 more source

MTHFR gene polymorphisms in hypothyroidism and hyperthyroidism among Jordanian females

Archives of Endocrinology and Metabolism, 2019
Objective Methylenetetrahydrofolate reductase (MTHFR) is involved in DNA methylation that is associated with autoimmune pathology. We investigated the association between MTHFR genetic polymorphisms at g.677C>T and g.1298A>C and their haplotypes, and ...
Diala W. Abu-Hassan, Abdullah N. Alhouri, Nadera A. Altork, Zakaria W. Shkoukani, Tamer Salhab Altamimi, Omar M. Alqaisi, Baha Mustafa   +6 more
doaj   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Effects of Enflurane and Epidural Anesthesia on Thyroid Hormone Changes with or without Liver Dysfunction [PDF]

, 1992
The levels of thyroid hormones are well known to respond to anesthetics and surgical stresses. The conversion of T4 to T3 is also affected by liver function.
Honda, Natsuo, Iwasaka, Hideo, Taniguchi, Kazuo, Okada, Kuniko   +3 more
core  

Initial low‐dose oral levothyroxine in a child with Down syndrome, myxedema, and cardiogenic shock

Clinical Case Reports, 2019
Myxedema is extremely rare in children, and guidelines are lacking. We treated a 12‐year‐old girl with myxedema and cardiogenic shock with initial low dose (0.3‐2.5 μg/kg body weight/day) of oral levothyroxine and intensive care.
Annika Janson, Cathrin Hällström, Magnus Iversen, Mikael Finder, Amira Elimam, Ricard Nergårdh   +5 more
doaj   +1 more source

Optimizing Expectations Leads to Enhanced Efficacy of a Mindfulness‐Based Intervention in Individuals With Low‐Baseline Expectations: A Randomized Controlled Trial

Journal of Clinical Psychology, EarlyView.
ABSTRACT Introduction Treatment expectations for medical and psychological treatments and positive patient‐provider interactions are critical mechanisms driving the placebo effect and may augment an intervention's effects. However, it remains unclear whether optimizing treatment expectations is beneficial for all individuals.
Stefan Salzmann, Frank Euteneuer, Christiane A. Melzig, Winfried Rief, Christoph Benke   +4 more
wiley   +1 more source