Results 81 to 86 of about 218 (86)
Global mapping of RNA N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) in human subcutaneous and visceral adipose tissue reveals novel targets that correlate with clinical variables of obesity. [PDF]
Biomark ResRønningen T +17 more
europepmc +1 more source
TIAF1 Participates in the Transforming Growth Factor β1-Mediated Growth Regulation
Annals of the New York Academy of Sciences, 2003 Abstract: TGF‐β induces growth suppression and apoptosis of various types of cells, but supports fibroblast growth. We previously isolated TIAF1 (TGF‐β1‐induced antiapoptotic factor 1), which protects murine L929 fibroblasts from TNF cytotoxicity. Here, we show that TIAF1 induced growth inhibition and apoptosis of monocytic U937 and other types of ...
Nan-Shan Chang
exaly +4 more sources
Weighted burden analysis of exome-sequenced late-onset Alzheimer's cases and controls provides further evidence for a role for PSEN1 and suggests involvement of the PI3K/Akt/GSK-3β and WNT signalling pathways [PDF]
Annals of Human Genetics, 2020 Previous studies have implicated common and rare genetic variants as risk factors for late-onset Alzheimer's disease (LOAD). Here, weighted burden analysis was applied to over 10,000 exome-sequenced subjects from the Alzheimer's Disease Sequencing ...
David Curtis
exaly +3 more sources
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DNA and Cell Biology, 2004
TIAF1 is a TGF-beta 1-induced factor that protects L929 fibroblasts from TNF-mediated apoptosis. In contrast, overexpressed TIAF1 induces growth inhibition and apoptosis of monocytic U937 and various nonfibroblast cells. TIAF1-mediated apoptosis of U937 cells involves upregulation of p53, p21, and Smad2/4, but downregulation of ERK phosphorylation.
James R. Heath +2 more
exaly +3 more sources
TIAF1 is a TGF-beta 1-induced factor that protects L929 fibroblasts from TNF-mediated apoptosis. In contrast, overexpressed TIAF1 induces growth inhibition and apoptosis of monocytic U937 and various nonfibroblast cells. TIAF1-mediated apoptosis of U937 cells involves upregulation of p53, p21, and Smad2/4, but downregulation of ERK phosphorylation.
James R. Heath +2 more
exaly +3 more sources
TIAF1 self-aggregation is essential for Aβ plaque formation in the human hippocampus
FASEB Journal, 2010 Role of TIAF1 in the TGF‐β pathway leading to the pathogenesis of Alzheimer's disease (AD) was investigated. We determined that TIAF1 bound Smad4 and blocked its‐regulated promoter activation. TGF‐β1 induced self‐aggregation of transiently overexpressed TIAF1 in a type II TGF‐β receptor (TβRII)‐independent ...
Nan-Shan Chang +2 more
exaly +2 more sources