Results 1 to 10 of about 1,772,736 (291)
Is PML a tumor suppressor? [PDF]
Frontiers in Oncology, 2013 The role of the promyelocytic leukemia protein (PML) has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature.
Massimiliano eMazza +1 more
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At the double for tumor suppressor
eLife, 2016 Research on zebrafish reveals how a tumor suppressor works in two different types of cells, and how hypotonic stress promotes tumor formation when the function of this tumor suppressor is lost.
Mahendra Sonawane
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Tumor suppressor genotype influences the extent and mode of immunosurveillance in lung cancer [PDF]
Nature CommunicationsThe impact of cancer driving mutations on immunosurveillance throughout tumor development remains poorly understood. To better understand the contribution of tumor genotype to immunosurveillance, we generated and validated lentiviral-based vectors that ...
Keren M. Adler +8 more
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Lowered Expression of Tumor Suppressor Candidate MYO1C Stimulates Cell Proliferation, Suppresses Cell Adhesion and Activates AKT. [PDF]
PLoS ONE, 2016 Myosin-1C (MYO1C) is a tumor suppressor candidate located in a region of recurrent losses distal to TP53. Myo1c can tightly and specifically bind to PIP2, the substrate of Phosphoinositide 3-kinase (PI3K), and to Rictor, suggesting a role for MYO1C in ...
Kittichate Visuttijai +10 more
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Tumor suppressor network dysregulation in neuroblastoma: molecular mechanisms and precision therapeutic opportunities [PDF]
Frontiers in Cell and Developmental BiologyNeuroblastoma is the most common extracranial solid malignancy in children and accounts for nearly 15% of paediatric cancer-related mortality, underscoring its substantial clinical burden.
Rohan Gupta +8 more
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SIRT1, Is It a Tumor Promoter or Tumor Suppressor? [PDF]
International Journal of Biological Sciences, 2009 SIRT1 has been considered as a tumor promoter because of its increased expression in some types of cancers and its role in inactivating proteins that are involved in tumor suppression and DNA damage repair. However, recent studies demonstrated that SIRT1
Chu-Xia Deng
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Biomolecules, 2022 Epstein-Barr virus (EBV) is ubiquitous and carried by approximately 90% of the world’s adult population. Several mechanisms and pathways have been proposed as to how EBV facilitates the pathogenesis and progression of malignancies, such as Hodgkin’s ...
Adelaide Ohui Fierti +4 more
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Retinoblastoma Protein Paralogs and Tumor Suppression
Frontiers in Genetics, 2022 The retinoblastoma susceptibility gene (RB1) is the first tumor suppressor gene discovered and a prototype for understanding regulatory networks that function in opposition to oncogenic stimuli.
Mauricio Flores, David W. Goodrich
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Tumor suppressor genes in the tumor microenvironment
Disease Models & MechanismsABSTRACT Tumor suppressor genes (TSGs) are thought to suppress tumor development primarily via cancer cell-autonomous mechanisms. However, the tumor microenvironment (TME) also significantly influences tumorigenesis. In this context, a role for TSGs in the various cell types of the TME in regulating tumor growth is emerging.
Bahareh Tabanifar +2 more
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Life Science Alliance, 2023 Deep mutational interaction perturbation scanning of NF2 with conformation-dependent interaction partners KDM1A, EMILIN, and PIK3R3 revealed two regions critical for NF2 tumor suppressor function. NF2 (moesin–ezrin–radixin-like [MERLIN] tumor suppressor)
Christina S Moesslacher +9 more
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