Results 31 to 40 of about 1,772,736 (291)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas. [PDF]

Mol Oncol
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Taqvi A, Huynh TK, Kadam A, Kardan Z, Yan Y, Laham AJ, Loganathan SK.   +6 more
europepmc   +2 more sources

TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma [PDF]

, 2009
Proliferation and survival of Hodgkin and Reed/Sternberg (HRS) cells, the malignant cells of classical Hodgkin lymphoma (cHL), are dependent on constitutive activation of nuclear factor {kappa}B (NF-{kappa}B).
Inga Vater, Giefing, Maciej, Vater, Inga, Hartmann, Sylvia, Martin-Leo Hansmann, Martin-Subero, Jose Ignacio, Bohle, Verena, Küppers, Ralf, Jens Stanelle, Ralf Küppers, Sylvia Hartmann, Gunhild Mechtersheimer, Hansmann, Martin-Leo, Gesk, Stefan, Jose Ignacio Martin-Subero, Stanelle, Jens, Verena Bohle, Siebert, Reiner, Roland Schmitz, Klapper, Wolfram, Maciej Giefing, Wolfram Klapper, Mechtersheimer, Gunhild, Schmitz, Roland, Stefan Gesk, Reiner Siebert   +25 more
core   +1 more source

Oncogene/Tumor Suppressor Molecular Pathways

MedEdPORTAL, 2010
Introduction Tumor suppressor genes and oncogenes are involved in a complex network of intra- and extracellular components that ultimately result in uncontrolled cell reproduction or apoptosis.
Dan Cushman, Robert Warren
doaj   +1 more source

Microbial Regulation of p53 Tumor Suppressor. [PDF]

PLoS Pathogens, 2015
p53 tumor suppressor has been identified as a protein interacting with the large T antigen produced by simian vacuolating virus 40 (SV40). Subsequent research on p53 inhibition by SV40 and other tumor viruses has not only helped to gain a better ...
Alexander I Zaika, Jinxiong Wei, Jennifer M Noto, Richard M Peek   +3 more
doaj   +1 more source

The role of the tumor suppressor CYLD in Yersinia enterocolitica infection [PDF]

, 2012
Recent studies have identified the tumor suppressor CYLD as a key regulator of NF -κB, a transcription factor that promotes cell survival and oncogenesis, as well as host defence to infection.
Liu, Yunying
core   +1 more source

Large 1p36 Deletions Affecting Arid1a Locus Facilitate Mycn-Driven Oncogenesis in Neuroblastoma

Cell Reports, 2020
Summary: Loss of heterozygosity (LOH) at 1p36 occurs in multiple cancers, including neuroblastoma (NBL). MYCN amplification and 1p36 deletions tightly correlate with markers of tumor aggressiveness in NBL.
Jesus García-López, Kirby Wallace, Joel H. Otero, Rachelle Olsen, Yong-dong Wang, David Finkelstein, Brian L. Gudenas, Jerold E. Rehg, Paul Northcott, Andrew M. Davidoff, Kevin W. Freeman   +10 more
doaj   +1 more source

Tumor-suppressor-oncogene-scores (TSOS).

, 2018
(a) Enrichment analysis using expression derived tumor-suppressor-oncogene-score (TSOS) in human tumors microarray and TCGA/GTEx RNAseq datasets for the whole candidate ortholog gene set (n = 619 and n = 637 respectively) in 1 million random samplings ...
Helena E. Richardson (434920), Shane J. F. Cronin (5859743), Lee Willoughby (5859722), Patrick O. Humbert (136871), Andreas Wernitznig (731157), Constantine S. Mitsiades (348466), Sofya Golenkina (5859731), Susanne Gruber (5859737), Ricardo Matos de Simoes (5859725), G. Gregory Neely (113800), Jan Manent (5859719), Elisabeth Eva Kanitz (368265), Kaylene J. Simpson (146322), Josef M. Penninger (113854), Tamara Zoranovic (5859716), John E. La Marca (5859728), Belinda Angjeli (5859740), Xia Cuiping (5859734)   +17 more
core   +1 more source

Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining. [PDF]

, 2015
Deficiencies in DNA double-strand break (DSB) repair lead to genetic instability, a recognized cause of cancer initiation and evolution. We report that the retinoblastoma tumor suppressor protein (RB1) is required for DNA DSB repair by canonical non ...
Spanswick, VJ, Maciej T. Luczynski, Cook, R, Hartley, JA, Paul H. Huang, Victoria J. Spanswick, John A. Hartley, Luczynski, MT, Rieger, S, Mittnacht, S, Moquet, J, Huang, PH, Kai Rothkamm, Jayne Moquet, Zoumpoulidou, G, Georgia Zoumpoulidou, Simone Rieger, Sibylle Mittnacht, Rothkamm, K, Rebecca Cook   +19 more
core   +1 more source

WT1 (Wilms' tumor suppressor gene) [PDF]

, 1999
Review on WT1 (Wilms' tumor suppressor gene), with data on DNA, on the protein encoded, and where the gene is ...
Gessler, M
core   +1 more source

Theoretical and in silico Analyses Reveal MYC as a Dynamic Network Biomarker in Colon and Rectal Cancer

Frontiers in Genetics, 2020
In this article, we make a theoretical and in silico study for uncovering and evaluating biomarkers in colon and rectal cancer (CRC) by the dynamic network biomarker (DNB) theory.
Yanqiu Tong, Yanqiu Tong, Yang Song, Chuanhui Xia, Shixiong Deng   +4 more
doaj   +1 more source