Results 21 to 30 of about 633,270 (301)
Nature Communications, 2023 The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a favorable prognosis. Here we highlight a function of p140Cap in orchestrating local and systemic tumor-extrinsic events that eventually result in inhibition of the ...
Vincenzo Salemme +32 more
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Down-regulation of myopodin expression reduces invasion and motility of PC-3 prostate cancer cells [PDF]
, 2009 Enhanced motility of cancer cells by remodelling of the actin cytoskeleton is crucial in the process of cancer cell invasion and metastasis. Although several studies propose a tumor suppressor role for the actin bundling protein myopodin, it was also ...
Bracke, Marc +5 more
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At the double for tumor suppressor
eLife, 2016 Research on zebrafish reveals how a tumor suppressor works in two different types of cells, and how hypotonic stress promotes tumor formation when the function of this tumor suppressor is lost.
Mahendra Sonawane
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Advanced Science, 2022 Atovaquone, an FDA‐approved drug for malaria, is known to inhibit mitochondrial electron transport. A recently synthesized mitochondria‐targeted atovaquone increased mitochondrial accumulation and antitumor activity in vitro. Using an in situ vaccination
Mofei Huang +9 more
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Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards [PDF]
, 2016 Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample evidence supports key contributions of MDSC to tumour progression through both immune ...
Brandau, Sven +14 more
core +2 more sources
Frontiers in Oncology, 2013 The role of the promyelocytic leukemia protein (PML) has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature.
Massimiliano eMazza +1 more
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Extracellular vesicles produced in B cells deliver tumor suppressor miR-335 to breast cancer cells disrupting oncogenic programming in vitro and in vivo. [PDF]
, 2018 The successful implementation of miRNA (miR) therapies in humans will ultimately rely on the use of vehicles with improved cellular delivery capability. Here we tested a new system that leverages extracellular vesicles (EVs) laden with a tumor suppressor
Almanza, Gonzalo +5 more
core +2 more sources
The RASSF1A tumor suppressor [PDF]
Journal of Cell Science, 2007 RASSF1A (Ras association domain family 1 isoform A) is a recently discovered tumor suppressor whose inactivation is implicated in the development of many human cancers. Although it can be inactivated by gene deletion or point mutations, the most common contributor to loss or reduction of RASSF1A function is transcriptional silencing of the gene by ...
Howard, Donninger +2 more
openaire +2 more sources
Roles of tumor suppressors in regulating tumor-associated inflammation. [PDF]
, 2014 Loss or silencing of tumor suppressors (TSs) promotes neoplastic transformation and malignant progression. To date, most work on TS has focused on their cell autonomous effects.
Karin, M, Yang, L
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Oncogene/Tumor Suppressor Molecular Pathways
MedEdPORTAL, 2010 Introduction Tumor suppressor genes and oncogenes are involved in a complex network of intra- and extracellular components that ultimately result in uncontrolled cell reproduction or apoptosis.
Dan Cushman, Robert Warren
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