Results 51 to 60 of about 633,270 (301)

miRNAs link metabolic reprogramming to oncogenesis [PDF]

, 2013
The most profound biochemical phenotype of cancer cells is their ability to metabolize glucose to lactate, even under aerobic conditions. This alternative metabolic circuitry is sufficient to support the biosynthetic and energy requirements for cancer ...
Hatziapostolou, M, Iliopoulos, D, Polytarchou, C   +2 more
core   +1 more source

WWOX tumor suppressor gene.

Histology and histopathology, 2008
Loss of heterozygosity and chromosomal rearrangement of the WWOX gene, which is located at 16q23.3-24.1, have been detected in ovarian, breast, hepatocellular, and prostate carcinomas and in other neoplasias. This gene, which spans the common chromosomal fragile site 16D, contains 9 exons and encodes a 46 kDa WWOX protein that contains 414 amino acids.
Yang, Jilong, Zhang, Wei
openaire   +3 more sources

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Loss of Expression of Reprimo, a p53-induced Cell Cycle Arrest Gene, Correlates with Invasive Stage of Tumor Progression and p73 Expression in Gastric Cancer. [PDF]

PLoS ONE, 2015
Reprimo (RPRM), a downstream effector of p53-induced cell cycle arrest at G2/M, has been proposed as a putative tumor suppressor gene (TSG) and as a potential biomarker for non-invasive detection of gastric cancer (GC).
Kathleen Saavedra, José Valbuena, Wilda Olivares, María José Marchant, Andrés Rodríguez, Verónica Torres-Estay, Gonzalo Carrasco-Avino, Leda Guzmán, Francisco Aguayo, Juan Carlos Roa, Alejandro H Corvalán   +10 more
doaj   +1 more source

Promoter Methylation of Tumor Suppressors in Thyroid Carcinoma: A Systematic Review

Iranian Journal of Public Health, 2021
Background: The tumor suppressor genes play a critical role in cellular and molecular mechanisms such as cell cycle processes, cell differentiation and apoptosis.
Sara Sheikkholeslami, Marjan Zarif -Yeganeh, Samaneh Farashi, Fereidoun Azizi, Sima Kheradmand Kia, Ladan Teimoori-Toolabi, Mehdi Hedayati   +6 more
doaj   +1 more source

PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth. [PDF]

, 2019
p53 acetylation is indispensable for its transcriptional activity and tumor suppressive function. However, the identity of reader protein(s) for p53 acetylation remains elusive. PBRM1, the second most highly mutated tumor suppressor gene in kidney cancer,
Cai, Weijia, Dulaimi, Essel, Jiang, Wei, Langbein, Lauren, Liao, Lili, Liu, Zongzhi Z, Su, Liya, Testa, Joseph R, Uzzo, Robert G, Yan, Qin, Yang, Haifeng, Zhang, Qing, Zhong, Zhijiu   +12 more
core   +1 more source

Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer [PDF]

, 2016
Tumor–stroma interactions contribute to tumorigenesis. Tumor cells can educate the stroma at primary and distant sites to facilitate the recruitment of heterogeneous populations of immature myeloid cells, known as myeloid-derived suppressor cells (MDSCs).
Ali Zamani, Andrea Wang-Gillam, Aude-Hélène Capietto, Barcellos-Hoff, Biancamaria Ricci, Bindea, Capietto, David B. Bumpass, David G. DeNardo, Fowler, Gabitass, Gabrilovich, Gabrilovich, Galon, Hamanishi, Katherine Weilbaecher, Li, Liu, Lucia D’Amico, MacDonald, Mace, Mahmoud, Melissa Meyer, Mitchem, Mundy-Bosse, Pinzone, Porembka, Roberta Faccio, Räsänen, Sahil Mahajan, Schreiber, Sheila A. Stewart, Tian, Trikha, Weilbaecher, Xinming Su, Yaccoby, Yamabuki, Yang, Zhang, Zhang, Zheng, Zhengfeng Yang, Zhu   +43 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Expression of WW Domain-Containing Oxidoreductase WOX1 in Human Nervous System Tumors

Analytical Cellular Pathology, 2013
Background and ObjectiveS: We aimed to evaluate the expression levels of the tumor suppressor WOX1 in nervous system tumors and its co-expression with p53 and neurofibromatosis type 2/merlin (NF2) tumor suppressor gene products.
Ming-Fu Chiang, Shur-Tzu Chen, Chen-Peng Lo, Chun-I Sze, Nan-Shan Chang, Yu-Jen Chen   +5 more
doaj   +1 more source

HuntING4 New Tumor Suppressors [PDF]

Cell Cycle, 2005
The well-characterized function of many tumor suppressors is to directly regulate cell cycle events. We recently reported a genetic screen to identify genes that suppress loss of contact inhibition but do not inhibit normal cell proliferation. ING4, one of the genes identified by the screen, is frequently mutated in human cancer, suggesting a role for ...
openaire   +2 more sources