Results 31 to 40 of about 132,451 (265)

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Outpatient Nonunion Fracture Repair of the Lower Extremity is Safe with Appropriate Patient Selection: A Propensity-Matched Database Analysis

Journal of Limb Lengthening & Reconstruction
Background: With rising healthcare costs and advances in surgical and anesthetic techniques, outpatient surgery has become increasingly common. This study evaluates differences in postsurgical complications between inpatient and outpatient femur and ...
Jesse Seilern Und Aspang, Amber Alexis Hamilton, Roberto Hernandez-Irizarry   +2 more
doaj   +1 more source

Box rest and analgesia compared to arthroscopic debridement for lame horses with hindlimb subchondral lucencies

Veterinary Evidence, 2023
Category of research Treatment. Number and type of study designs reviewed Two relevant publications were found, both were retrospective case series. Strength of evidence Weak.
Charlotte Taylor, Julia Dubuc
doaj   +1 more source

Intelligent Orthopedics: Machine Learning in Diagnosis of Bone Disease, Implants, and Bone Health Monitoring

Advanced Healthcare Materials, EarlyView.
Efficient recovery from traumatic or degenerative diseases is a great challenge, even after all the advancements in bone and cartilage regeneration. Machine learning (ML) algorithms have presented opportunities to enhance these aspects by accurately analyzing imaging data.
Maryam Kamaei, Hesam Mohammadi, Shamim Golafshan, Mojtaba Alehosseini, Mahsa Mohammadzadeh, Atefeh Golshirazi, Nasim Golafshan, Tatiane Eufrásio‐da‐Silva, Alireza Dolatshahi‐Pirouz, Gorka Orive   +9 more
wiley   +1 more source

Osteofibrous Dysplasia Involving Both Tibia and Fibula: A Rare Campanacci-Type Presentation

Journal of the Belgian Society of Radiology
Teaching point: Osteofibrous dysplasia (OFD) is a rare benign fibro‑osseous lesion primarily affecting the tibial cortex in children and adolescents; simultaneous involvement of the fibula is exceptional and may mimic more aggressive tumors such as ...
Caroline Chabot, Daniel Janssens
doaj   +1 more source

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Case Report: 3D-Printed Prosthesis for Limb Salvage and Joint Preservation After Tibial Sarcoma Resection

Frontiers in Surgery, 2022
IntroductionReconstruction of massive tibial defects in ankle joint-preserving surgery remains challenging though biological and prosthetic methods have been attempted.
Zehao Guo, Ran Zhang, Yukang Que, Bo Hu, Shenglin Xu, Yong Hu   +5 more
doaj   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

Dynamic Mechanical Loading Modulates Extracellular Vesicle Production and Cargo in Meniscus Fibrochondrocytes

Advanced Materials Interfaces, EarlyView.
Dynamic mechanical loading of outer meniscus fibrochondrocytes increases extracellular vesicle (EV) yield and alters EV composition. When applied to progenitor cells, these mechanically primed EVs modulate the expression of matrix‐related genes.
Catherine Cheung, Zizhao Li, Sung‐Han Jo, Se‐Hwan Lee, Il Keun Kwon, Jina Ko, Su Chin Heo   +6 more
wiley   +1 more source

Anatomy of the Medial Meniscotibial Ligament of the Knee: A Systematic Review

Revista Brasileira de Ortopedia, 2023
Objectives To perform a systematic review of the literature on the anatomy of the medial meniscotibial ligaments (MTLs), and to present the most accepted findings, as well as the evolution of the anatomical knowledge on this structure.
Jonatas Brito de Alencar Neto, Amanda Progênio dos Santos, Márcio Bezerra Gadelha Lopes, Lana Lacerda de Lima, Renata Clazzer, Diego Ariel de Lima   +5 more
doaj   +2 more sources