Results 211 to 220 of about 431,638 (270)

Senotherapeutics for Knee Osteoarthritis

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman   +6 more
wiley   +1 more source

Cumulative effects of lifelong systemic excess growth hormone on postcranial skeletal morphology in adult mice

open access: yesJournal of Anatomy, EarlyView.
Our μCT‐based pilot study reveals size and shape disparity in the adult postcranial skeleton of growth‐hormone model (bGH) mice relative to wild‐type mice. bGH mice have larger and more sexually dimorphic bones, with a systemic radiodensity increase in bony sesamoids and associated, but typically uncalcified, soft tissues.
Joseph R. Groenke   +7 more
wiley   +1 more source

Can Knee Arthroscopy Be Considered Entirely Safe for Patients Over 50 Years Old With no Risk of Osteonecrosis? Case Series and Literature Review on Post‐Artrhoscopy Osteonecrosis of the Knee (PAONK)

open access: yesOrthopaedic Surgery, Volume 17, Issue 5, Page 1378-1388, May 2025.
Post‐arthroscopy osteonecrosis is a rare complication occurring in 0.82% of cases, primarily affecting patients over 50 with degenerative meniscal tears. Early detection through MRI and conservative treatment, including bisphosphonates and weight‐bearing avoidance, proved effective in most cases, while some required surgical intervention.
Panagiotis Ntagiopoulos   +9 more
wiley   +1 more source

Biomechanical Superiority of the Chinese Knotting Technique in Posterior Cruciate Ligament Reconstruction: A Cadaveric Study

open access: yesOrthopaedic Surgery, EarlyView.
In cadaveric PCL reconstruction, the Chinese knotting technique preserves graft mechanics, significantly increases maximum load, and limits elongation, supporting early rehabilitation and reducing failure risk. ABSTRACT Objective We previously developed a novel internal tension‐relieving augmentation suture, the Chinese knotting technique (CKT), which ...
Zhengliang Shi   +9 more
wiley   +1 more source

Orthopedic Mechanophenotype: A Structured Narrative Review of Multiscale Biomechanics, Mechanotransduction, and Clinical Decision‐Making

open access: yesOrthopaedic Surgery, EarlyView.
The orthopedic mechanophenotype framework comprises load exposure, tissue susceptibility, and biological adaptability axes to decode mechanical‐biological crosstalk. It guides clinical phenotyping, targeted intervention, and response monitoring for orthopedic disorders beyond static morphological assessment.
Zihao Lan, Zhipeng Mu, Hongjian Li
wiley   +1 more source

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