Results 221 to 230 of about 431,638 (270)

Clinical Outcomes and Patient Experiences With Celiprolol Therapy in Vascular Ehlers–Danlos Syndrome: The First Non‐European Cohort

American Journal of Medical Genetics Part A, Volume 200, Issue 10, Page 2241-2249, October 2026.
ABSTRACT Vascular Ehlers–Danlos syndrome (vEDS) is a hereditary connective tissue disorder caused by heterozygous pathogenic variants in COL3A1. European studies have shown that celiprolol may reduce the risk of life‐threatening vascular events, but outcomes in non‐European populations and the therapy's psychological impact remain unclear. We conducted
Megumi Furuhata‐Yoshimura, Tomomi Yamaguchi, Tomoki Kosho   +2 more
wiley   +1 more source

Musculoskeletal (Mal)adaptations in Response to a > 30 000‐km Running Challenge

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.
ABSTRACT Background Ultra‐endurance sports are increasingly popular, yet the long‐term physiological consequences of sustained extreme training loads remain poorly understood. In particular, the effects of prolonged ultra‐endurance exercise on skeletal muscle structure, function and molecular remodelling are largely unknown.
Tomas Venckunas, Thomas Chaillou, Leonardo Cesanelli, Danguole Satkunskiene, Saulius Rutkauskas, Audrius Snieckus, Petras Minderis, Darja Nikitina, Jurgita Skieceviciene, Juozas Kupcinskas, Lorenz Webersberger, Johanna T. Lanner, Mantas Mickevicius, Birutė Gumauskiene, Asta Kuzmickaite, Andrejus Subocius, Sigitas Kamandulis   +16 more
wiley   +1 more source

Severe medial tibial plateau fractures: feasibility and functional and radiographic results of an extended approach with medial femoral epicondyle osteotomy. [PDF]

J Orthop Surg Res
Gablac H, Arras C, Behrendt P, Fahlbusch H, Galavics C, Hoffmann M, Frosch KH, Krause M.   +7 more
europepmc   +1 more source

Microanatomical features of bovids long bones: What are the effects of mass and habitat?

Journal of Anatomy, Volume 249, Issue 4, Page 899-923, October 2026.
This study provides the first qualitative and quantitative exploration of inter‐bones and interspecific variations in the microanatomy of long bones in bovids in response to significant changes in body mass and habitat. Abstract Bovids are a valuable group for studying limb long bone adaptations due to differences in size and the environment that the ...
Morgan Proust, Cyril Etienne, Alexandra Houssaye   +2 more
wiley   +1 more source

Dynamic Mechanical Loading Modulates Extracellular Vesicle Production and Cargo in Meniscus Fibrochondrocytes

Advanced Materials Interfaces, Volume 13, Issue 17, 8 September 2026.
Dynamic mechanical loading of outer meniscus fibrochondrocytes increases extracellular vesicle (EV) yield and alters EV composition. When applied to progenitor cells, these mechanically primed EVs modulate the expression of matrix‐related genes.
Catherine Cheung, Zizhao Li, Sung‐Han Jo, Se‐Hwan Lee, Il Keun Kwon, Jina Ko, Su Chin Heo   +6 more
wiley   +1 more source

Mechanical Activation of Piezo1 Drives Osteoarthritis Through Kdm5c‐Mediated Epigenetic Silencing

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Excessive mechanical stress activates Piezo1, triggering Ca2+‐dependent cytoskeletal forces that deform the nucleus and reduce H3K4me3. Kdm5c demethylates H3K4me3 at Col2a1 and Runx3 promoters. Kdm5c knockout rescues degradation. Repurposed telmisartan directly inhibits Kdm5c, blocking this axis and showing disease‐modifying efficacy in mouse OA models
Tianyou Kan, Xuran Li, Han Wang, Lin Sun, Yao Wang, Jiangdong Wu, Junqi Cui, Yiqi Yang, Kai Yuan, Linyang Chu, Liao Wang, Hanjun Li, Mengning Yan, Zhifeng Yu   +13 more
wiley   +1 more source

The Potential Role of Synovial T Cell Infiltration Following Knee Joint Injury in Symptoms and Progression to Osteoarthritis

Arthritis &Rheumatology, Volume 78, Issue 9, Page 1863-1877, September 2026.
Objective Identification of osteoarthritis (OA)–specific synovial inflammatory pathways and their temporal relevance is critical for therapeutic targeting. We compared mononuclear inflammatory/immune cell responses following joint injury that does or does not lead to OA to define bona fide OA‐associated cellular events.
Babak Moradi, Miriam T. Jackson, Cindy C. Shu, Susan M. Smith, Margaret M. Smith, Sanaa Zaki, Hadrian Platzer, Nils Rosshirt, David Giangreco, Carla R. Scanzello, Christopher B. Little   +10 more
wiley   +1 more source

Clinical and MRI Restoration of ACL Continuity Following Functional Complete ACL Rupture in an Adolescent Athlete: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Restoration of ACL continuity and clinical stability may occur in selected adolescents with functional ACL insufficiency. This case highlights the potential value of repeat clinical and MRI assessment before proceeding with definitive ACL reconstruction when clinical circumstances permit.
Hooman Angoorani, Molood Jafari Fesharaki, Chakavak Valadkhani, Hossein Safaei   +3 more
wiley   +1 more source

Report on the 13th international workshop on the CCN family of genes and inaugural ARBIOCOM conference, Nice, France

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Celebration of the 13th ICCNS meeting joint to the 1st ARBIOCOM Conference held on the site of Nice in December 2025. Abstract The 13th International Workshop on the CCN Family of Genes, held in Nice as part of the inaugural ARBIOCOM World Conference, brought together investigators with diverse research backgrounds, disciplines, and expertise. Building
Bernard Perbal, Ralf Weiskirchen, Annick Perbal, Brahim Chaqour   +3 more
wiley   +1 more source

Pie‐crusting the medial collateral ligament is a safe and effective technique for improving visualisation and access in arthroscopic meniscal surgery: A systematic review

Knee Surgery, Sports Traumatology, Arthroscopy, Volume 34, Issue 9, Page 3298-3313, September 2026.
Abstract Purpose To assess the safety, effectiveness, and postoperative outcomes of medial collateral ligament (MCL) pie‐crusting (PC) in arthroscopic meniscus surgery. Methods This systematic review was conducted in accordance with PRISMA guidelines.
Satyavenkata Kotipalli, Benjamin Blackman, Prushoth Vivekanantha, Marc Daniel Bouchard, Amit Meena, Shahbaz Malik, Darren de SA   +6 more
wiley   +1 more source