Results 41 to 50 of about 35,271 (283)

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Mechanism of Qihuang needle therapy in the management of tic disorders: a clinical trial protocol

Frontiers in Neurology, 2023
BackgroundQihuang needle therapy is a newly developed acupuncture therapy to treat tic disorders in clinical practice. However, the mechanism to reduce tic severity remains unknown.
Yuyuan Tang, Jun'e Wu, Zhirui Xu, Baochao Fan, Xiangli Li, Bingxu Jin, Chunzhi Tang   +6 more
doaj   +1 more source

Therapy of tic-disorders

, 2004
Background: Within the last decade therapeutic approaches to tic disorders are reflected in many new studies. The advent of novel neuroleptics and the more sophisticated behavioural therapeutic techniques may give new hope to children and adolescents ...
Banaschewski, Tobias, Roessner, Veit, Rothenberger, A.   +2 more
core   +1 more source

Covalent Bonds Reinforced Strength and Modulus of Heterocyclic Aramid Fiber by Interfacial Aminated‐MXene Nanosheets

Advanced Science, EarlyView.
We demonstrate the covalent bonds strategy to enhance the mechanical property of PBIA fiber by using interfacial MXene‐NH2 nanosheets. The MXene‐NH2 nanosheets with reactive amino sites that can serve as nucleating agents and chain anchors to enhance orientation, crystallinity and interchain interaction of PBIA fiber via strong interfacial amido ...
Boyuan Chen, Hansheng Liu, Weiheng Kong, Ke Han, Jing Fang, Xingjiang Wu, Jianhong Xu, Hao Li   +7 more
wiley   +1 more source

Tic disorder in allergic rhinitis children and adolescents: a case-control study

BMC Pediatrics
Background Allergic rhinitis is the most common allergic disease. It can accompany psychological disorders such as tic disorders due to the prolonged course of the symptoms of allergic rhinitis.
Hossein Esmaeilzadeh, Mohammad Reza Yousefi, Negar Mortazavi, Mohammad Amin Gholami, Mohebat Vali, Seyed Ali Dastgheib   +5 more
doaj   +1 more source

Functional Motor Disorders in pediatrics: clinical motor correlates and neuropsychiatric profiles

, 2023
Background: Functional Motor Disorders (FMDs) in pediatric age represent an increasing challenge among acute movement manifestations, mostly for functional tic during the pandemic. The aim of our study was to distinguish possible specific clinical motor
Cardona F., Baglioni V., Conte G.
core  

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

The usefulness of heart rate variability in adolescents with tic disorder: Focused on interplay with quality of life.

PLoS ONE
BackgroundTic disorders, characterized by involuntary movements or vocalizations, are influenced by neurological and psychological factors. Although an imbalance in neurotransmitter systems, genetic factors, and environmental influences play a ...
Young Eun Mok, SuHyuk Chi, June Kang, Jeong-An Gim, Jeong-Kyung Ko, Moon-Soo Lee   +5 more
doaj   +1 more source

Expanding the Phenotype of TUFM‐Related Combined Oxidative Phosphorylation Deficiency 4

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Combined oxidative phosphorylation deficiency 4 (COXPD4) is a rare mitochondrial condition caused by biallelic deleterious variants in the nuclear‐encoded gene TUFM. To date, most individuals with COXPD4 have presented with encephalopathy, hypotonia, and abnormal brain imaging. Many of the reported individuals died in infancy. We aim to expand
Noémie Villeneuve‐Cloutier, Jodi Warman‐Chardon, Danielle K. Bourque   +2 more
wiley   +1 more source

A Patient-Centered Perspective on the Future of Tic Disorder Diagnosis: Response to “Tic disorders revisited: Introduction to the term ‘tic spectrum disorders” by Müller-Vahl et al.

, 2019
The paper, “Tic disorders revisited: Introduction to the term ‘tic spectrum disorders,” Müller-Vahl, Sambrani, and Jakubovski (2019) proposes a new diagnostic term “tic spectrum disorders” to encompass and replace diagnoses of Tourette Syndrome (TS ...
Christine Conelea, Ben Brown, Laura Beljaars, Jaleesa Jenkins   +3 more
core   +1 more source