Results 51 to 60 of about 1,474,594 (273)
Angewandte Chemie, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
Tic disorder in allergic rhinitis children and adolescents: a case-control study
BMC PediatricsBackground Allergic rhinitis is the most common allergic disease. It can accompany psychological disorders such as tic disorders due to the prolonged course of the symptoms of allergic rhinitis.
Hossein Esmaeilzadeh +5 more
doaj +1 more source
Mechanism of Qihuang needle therapy in the management of tic disorders: a clinical trial protocol
Frontiers in Neurology, 2023 BackgroundQihuang needle therapy is a newly developed acupuncture therapy to treat tic disorders in clinical practice. However, the mechanism to reduce tic severity remains unknown.
Yuyuan Tang +6 more
doaj +1 more source
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
Angewandte Chemie, EarlyView.An optimized strategy for the ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is incorporated into the RaPID platform, enabling high‐throughput discovery from topologically defined TiB libraries. Proof‐of‐concept selection against TNIK identifies nanomolar‐affinity ligands with inhibitory activity, while x‐ray crystallography ...
Yue Zhang +5 more
wiley +2 more sources
PLoS ONEBackgroundTic disorders, characterized by involuntary movements or vocalizations, are influenced by neurological and psychological factors. Although an imbalance in neurotransmitter systems, genetic factors, and environmental influences play a ...
Young Eun Mok +5 more
doaj +1 more source
Noradrenaline state in children with a tic disorders
Бюллетень сибирской медицины, 2009 The content of noradrenaline in blood serum in 28 children 6–16 years of age with tic disorder was analyzed. It was detected reliable descent the content of noradrenaline in blood serum of the children with a tic disorders compared the group of healthy ...
I. F. Fedoseyeva +2 more
doaj +1 more source
Validation of screening instruments for neuroepidemiological surveys of tic disorders
, 2011 Background: The main purpose was to validate a multistage protocol to screen tic disorders in mainstream and special education centers and to investigate whether telephone-based interviews were accurate to diagnose tic disorders when compared with in ...
Jose Maria Trejo Gabriel y Galán +19 more
core +1 more source
The Mind From Within: Visceral Roots of Human Cognition
Advanced Science, EarlyView.The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti +1 more
wiley +1 more source
Antipsychotics use in children with tic disorders: a cross-sectional study
Psychiatry and Clinical Psychopharmacology, 2021 INTRODUCTION: Tics are involuntary movements seen commonly and widespread in the childhood period as motor or vocal involuntary muscle contractions which show a sudden, rapid, intermittent, recurrent, non-rhythmic, stereotyped nature. Many patients with
Ebru Sekmen +3 more
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