Results 41 to 50 of about 54,446 (197)

Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux

Journal of Lipid Research, 2009
Peroxisome proliferator-activated receptor delta (PPARδ) is involved in regulation of energy homeostasis. Activation of PPARδ markedly increases fecal neutral sterol secretion, the last step in reverse cholesterol transport.
Carlos L.J. Vrins, Astrid E. van der Velde, Karin van den Oever, Johannes H.M. Levels, Stephane Huet, Ronald P.J. Oude Elferink, Folkert Kuipers, Albert K. Groen   +7 more
doaj   +1 more source

Untreated Hair Dye Effluents Enter the Environment: Are They a Threat to Human Health?

Environmental Toxicology, Volume 41, Issue 10, Page 998-1010, October 2026.
ABSTRACT The effluents generated during the process of hair dyeing exhibit a complex composition, comprising chemical compounds with varying toxicity levels. While the adverse impact of hair dyes on human health is acknowledged, there is a notable absence of studies addressing the toxicity associated with effluents produced during these activities. The
Letícia Cristina Gonçalves, Matheus Mantuanelli Roberto, Adriana Fabiana Corrêa da Silva, Maria Aparecida Marin‐Morales   +3 more
wiley   +1 more source

BCG strain S4-Jena: An early BCG strain is capable to reduce the proliferation of bladder cancer cells by induction of apoptosis

Cancer Cell International, 2010
Background Intravesical immunotherapy with Mycobacterium bovis bacillus Calmette-Guérin has been established as the most effective adjuvant treatment for high risk non-muscle-invasive bladder cancer (NMIBC). We investigated the differences between the S4-
Hermann Inge-Marie, Steiner Thomas, Foerster Martin, Schwarzer Katja, Straube Eberhard   +4 more
doaj   +1 more source

Reduction of VLDL secretion decreases cholesterol excretion in niemann-pick C1-like 1 hepatic transgenic mice. [PDF]

PLoS ONE, 2014
An effective way to reduce LDL cholesterol, the primary risk factor of atherosclerotic cardiovascular disease, is to increase cholesterol excretion from the body.
Stephanie M Marshall, Kathryn L Kelley, Matthew A Davis, Martha D Wilson, Allison L McDaniel, Richard G Lee, Rosanne M Crooke, Mark J Graham, Lawrence L Rudel, J Mark Brown, Ryan E Temel   +10 more
doaj   +1 more source

Population Pharmacokinetics and Exposure–Response of Sasanlimab, a Checkpoint Inhibitor, in Patients with Non‐Muscle Invasive Bladder Cancer and Other Solid Tumors

The Journal of Clinical Pharmacology, Volume 66, Issue 9, September 2026.
Abstract Sasanlimab is a monoclonal antibody (mAb) which blocks human programed cell death protein 1. It is administered subcutaneously (SC), currently under development for non‐muscle invasive bladder cancer (NMIBC) with a recommended flat dose of 300 mg every 4 weeks (Q4W).
Joanna C. Masters, Brian Jermain, Alan Liu, Rossano Cesari, Anna Maria Calella, Elisabete Michelon, Caimiao Wei, Susana Liu, Joseph Piscitelli   +8 more
wiley   +1 more source

Synchronous Ultrasonic Impact Treatment for Regulating Microstructure and Properties of Laser‐Directed Energy Deposited In Situ TiC/Ti6Al4V Composites

Rare Metals, Volume 45, Issue 9, September 2026.
ABSTRACT In laser‐directed energy deposition (LDED) of TiC/Ti6Al4V composites, a low content of micron‐sized TiC provides a good strengthening effect on hardness and strength, but the improvement in plasticity remains a challenge. By introducing synchronous ultrasonic impact treatment (UIT) into the LDED process, an ultrasonic‐assisted LDED (UA‐LDED ...
Yuzhou Zeng, Jiandong Wang, Weiming Cui, Qiheng Bai, Chenxinwei Wang, Xu Li, Chengbo Pan, Yunxiang Tong, Liqun Li, Peng He   +9 more
wiley   +1 more source

From philosophy to algorithms: a commentary on the evolution of human behavior and the role of artificial intelligence

Discover Artificial Intelligence
Background This commentary explores the evolution of how human behavior has been understood, from classical philosophical theories to modern applications in Applied Behavior Analysis (ABA), focusing on the emerging role of Artificial Intelligence (AI ...
Luca Vascelli
doaj   +1 more source

« E-maginaires » éducatifs : nécessaires utopies ou inutiles innovations ?

Interfaces Numériques, 2017
Cet article pose un regard critique sur la place de l’imaginaire dans le développement des technologies numériques dans l’enseignement supérieur français, durant les quinze dernières années.
Valérie Campillo-Paquet
doaj   +1 more source

A Fractal Link Between Soil Water Retention and Freezing

Journal of Geophysical Research: Solid Earth, Volume 131, Issue 9, September 2026.
Abstract Soils undergo wetting‐drying and freezing‐thawing cycles, yet their water retention and freezing behaviors are typically described within separate frameworks. This separation raises a fundamental question: do desaturation and freezing share comparable pore‐structure controls?
Hao Wang, Sai K. Vanapalli
wiley   +1 more source

Natural Killer Anti-Tumor Activity Can Be Achieved by In Vitro Incubation With Heat-Killed BCG

Frontiers in Immunology, 2021
Natural Killer cell receptors allow this heterogeneous immune population to efficiently fight both tumors and infection, so their use as immunotherapy agents is an active field of research.
Gloria Esteso, Nacho Aguiló, Esther Julián, Omodele Ashiru, Mei. M. Ho, Carlos Martín, Mar Valés-Gómez   +6 more
doaj   +1 more source