Results 151 to 160 of about 99,710 (378)
Chemistry – A European Journal, EarlyView.Herein, a sequential acyl‐thiol‐ene/S‐deacetylation protocol for selective installation of thiol residues onto synthetic peptides, on‐resin, is demonstrated. The hydrothiolation/S‐deacetylation protocol offers a novel synthetic tool for direct peptide conjugation on‐resin and for the preparation of novel disulfide containing neuropeptides displaying ...
Nikita Ostrovitsa +5 more
wiley +1 more source
International Journal for Parasitology: Parasites and Wildlife, 2022 Haemaphysalis chordeilis Packard, also known as the grouse or bird tick, is a three-host tick native to North America. Literature from the early 20th century reported a widespread distribution of this tick across the US and Canada.
Andrea Egizi, Lauren P. Maestas
doaj
Is Mycobacterial InhA a Suitable Target for Rational Drug Design?
ChemMedChem, EarlyView.InhA is the target of isoniazid, a first‐line antituberculosis drug. Isoniazid is, in fact, a prodrug that needs to be activated. Researchers are trying to develop direct inhibitors of InhA. This includes the resolution of crystallographic structures. The Protein Data Bank contains over a hundred InhA structures.
Julien Rizet +7 more
wiley +1 more source
First paediatric case of autochthonous tick-borne encephalitis in the Netherlands, 2018
New Microbes and New Infections, 2019 Since 2016, sporadic cases of autochthonous tick-borne encephalitis (TBE) have been encountered in the Netherlands, in two distinct geographic regions.
F. Geeraedts +2 more
doaj
Pan-disease clustering analysis of the trend of period prevalence [PDF]
arXiv, 2018 For all diseases, prevalence has been carefully studied. In the "classic" paradigm, the prevalence of different diseases has usually been studied separately. Accumulating evidences have shown that diseases can be "correlated". The joint analysis of prevalence of multiple diseases can provide important insights beyond individual-disease analysis ...
arxiv
Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities
ChemMedChem, EarlyView.Continuous flow technology is exploited for the generation of bicyclic pyrazolines via photo‐click reactions. These heterocyclic species contain a valuable 3D scaffold along with a polar succinimide moiety. Subsequent antimicrobial testing reveals that halogenated moieties such as chlorine atoms and trifluoromethoxy groups enhance the potency of these ...
Debora Caviglia +4 more
wiley +1 more source
Ticks and Tick-Borne DiseasesAs part of the NorthTick project, co-funded by the European Union through the European Regional Development Fund and the North Sea Region Programme, specialists in the field of tick-borne diseases from seven North Sea countries co-operated with patient ...
Randi Eikeland +13 more
doaj
New Pyridobenothiazolone Derivatives Display Nanomolar Pan‐Serotype Anti‐Dengue Virus Activity
ChemMedChem, EarlyView.A ligand‐based strategy is employed, starting from hit compound 2, to develop the C‐2 modified pyridobenzothiazolone 19 as a pan‐serotype nanomolar DENV‐1‐4 inhibitor. Investigations of the mechanism reveal the peculiar ability to abolish the infectivity of virions in a second infection.
Tommaso Felicetti +13 more
wiley +1 more source
Molecular surveillance reveals a potential hotspot of tick-borne disease in Yakeshi City, Inner Mongolia. [PDF]
BMC Microbiol, 2023 Tian J +6 more
europepmc +1 more source
In the United States, the blacklegged tick, Ixodes scapularis, is a vector of seven human pathogens, including those causing Lyme disease, anaplasmosis, babesiosis, Borrelia miyamotoi disease, Powassan virus disease, and ehrlichiosis associated with ...
core