Results 161 to 170 of about 182,962 (367)

Remote Conformational Control of a Chloride‐Binding Site

open access: yesChemistryEurope, EarlyView.
Chloride‐binding foldamers have been developed that have stereogenic C‐ and N‐terminal groups separated by a helical α‐aminoisobutyric acid (Aib) body. Chloride affinity is sensitive to the sense and strength of screw‐sense induction by each N‐terminal residue.
Rhodri Ll. Evans   +6 more
wiley   +1 more source

Nanogel‐Mediated Immunotherapy to Tackle Cancer and Inflammatory Diseases

open access: yesChemistryEurope, EarlyView.
Nanogels formed through self‐assembly, microemulsion, or precipitation polymerization method enable precise delivery of immunotherapeutic factors and immune cell targeting, thus effectively modulating immune responses. This review highlights recent advances in stimuli‐responsive nanogel design, underlying mechanisms, and their potentials to tackle ...
Ziwen Zhang   +7 more
wiley   +1 more source

Unlocking Biomolecule Modification with Light‐Promoted Photocatalyst‐Free Approaches: Current Tools, Challenges, and Perspectives

open access: yesChemistryEurope, EarlyView.
This Perspective focuses on photocatalyst‐free, photoinduced modifications of biomolecules, emphasizing transformations mediated by electron donor–acceptor complexes. Mechanistic aspects, current limitations, and future opportunities are discussed, providing insight into the field of bioconjugation.
Milene Hornink   +3 more
wiley   +1 more source

Fluorinated Guanidino‐Polyamine Conjugates With Ribonuclease Activity – Toward a Therapeutic Tool for Multi‐Drug Therapy

open access: yesChemistry – A European Journal, EarlyView.
This study presents a first‐in‐class demonstration of polymeric cationic gene delivery vectors that exhibit intrinsic artificial ribonuclease activity. Based on low‐generation PAMAM dendrimers and low molecular weight PEI polymers functionalized with a fluorinated linker containing a guanidino group, our conjugates simultaneously enable gene ...
Carola Romani   +4 more
wiley   +1 more source

Bioorthogonal Chemistry in Biomolecule Quantification: A Review of Reactions and Strategies

open access: yesChemistry – A European Journal, EarlyView.
This review summarizes the application of catalyst‐free bioorthogonal reactions: Staudinger ligation, strain promoted azide alkyne cycloaddition, inverse electron‐demand Diels–Alder, and 2‐cyanobenzothiazole cysteine condensation in the semi‐quantitative and quantitative analysis of biomolecules.
Mingze Yang, Shiqi Wang
wiley   +1 more source

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

open access: yesChemistry – A European Journal, EarlyView.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow   +2 more
wiley   +1 more source

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