Results 101 to 110 of about 2,440,906 (285)

DUSP26 Regulated by YY1 Lactylation Couples Osteogenesis and Angiogenesis by Dephosphorylating PMPCB at Y141 and Activating Mitophagy in BMSCs

Advanced Science, EarlyView.
p300‐associated YY1 lactylation promotes DUSP26 expression in BMSCs. By regulating PMPCB phosphorylation and PINK1 processing, DUSP26 supports mitophagy, osteogenic differentiation, and pro‐angiogenic factor secretion. BMSC‐derived exosomes carrying a RUNX2 promoter‐driven DUSP26 plasmid favor osteogenic‐lineage transgene expression, partially ...
Yunpeng Lv, Feng Wu, Xiongjie Liang, Chong Liu, Wenhui Guo, Kejian Zhang, Jiawen Niu, Wenjie Jiang, Hongjian Xu, Anlong Jiang, Yang Zheng, Enming Yu, Xintao Wang, Jinglong Yan, Jingjun Xia, Chengchao Song   +15 more
wiley   +1 more source

Northeastern China, a Hotspot for Tick-Borne Viral Diseases

Zoonoses
Northeastern China has a high incidence of tick-borne diseases. Emerging and re-emerging tick-borne viral diseases pose a considerable threat to public health.
Ziyan Liu, Zedong Wang
doaj   +1 more source

Topology‐Driven X‐Shaped DNA as a cGAS Stimulator to Promote Dendritic Cell Activation and Antitumor Vaccine Efficacy

Advanced Science, EarlyView.
X‐shaped DNA promotes multivalent cGAS assembly and enhances cGAS‐STING signaling. When conjugated with antigenic peptides, the resulting X‐DNA‐based peptide vaccine promotes dendritic cell activation, antigen presentation, and antitumor T‐cell responses.
Jiabei Li, Xuan Wang, Dali Wei, Zhejie Chen, Ziyi Wang, Qing Yu, Yu Yang, Shengpeng Wang   +7 more
wiley   +1 more source

Tick Blitz Toolkit [PDF]

The New York State (NYS) Tick Blitz was a collaborative effort between the Cornell University Department of Entomology: Harrington Lab and the New York State Integrated Pest Management Program, as well as the Northeast Regional Center for Excellence in ...
Northeast Regional Center for Excellence in Vector-Borne Diseases
core   +1 more source

Lyme arthritis: Demographic characteristics and Borrelia ospA genospecies in synovial fluid. A 17-year cohort study in Sweden

Ticks and Tick-Borne Diseases
Lyme arthritis (LA) is a recognized manifestation of Lyme borreliosis in Sweden, but data on the causative Borrelia species are limited. This study aimed to describe the demographics of LA and identify Borrelia burgdorferi sensu lato (B. burgdorferi s.l.)
Katharina Ornstein, Camilla Broholm, Ram B. Dessau, Ann-Cathrine Petersson   +3 more
doaj   +1 more source

pH‐Responsive Ultrasmall Iron Oxide Nanoassemblies for Activatable T2/T1 Magnetic Resonance Imaging

Advanced NanoBiomed Research, EarlyView.
This research reports a pH‐responsive ultrasmall iron oxide nanoparticle (USIONs)/polymer nanoassemblies for activatable magnetic resonance imaging. Amphiphilic diphosphonic acid block copolymers compactly encapsulate USIONs to generate T2‐weighted contrast at physiological pH, while acidic conditions trigger disassembly, activating T1‐weighted ...
Xumin Huang, Liwei Liu, Jiayuan Zhu, Xinghao Hu, Changkui Fu, Yao Wang, Lining Arnold Ju, Thomas P. Davis, Andriansjah Rukmana, Shaohua Ma, Zheng Zhang, Ruirui Qiao   +11 more
wiley   +1 more source

Performance of the French national hospital discharge database algorithm to identify hospitalised Lyme borreliosis cases, France, 2017–2018

BMC Infectious Diseases
Background In France, surveillance of Lyme borreliosis (LB) is based on general practitioners of a sentinel network and the national hospital discharge database (PMSI). Given the known limitations of the PMSI for epidemiological surveillance, we assessed
Alexandra Septfons, Leslie Grammatico-Guillon, Jean Capsec, Christophe Garborit, Adrien Lemaignen, Philippe Lanotte, Solène Patrat Delon, Pierre Tattevin, Alexandre Scanff, Florian Bouchet-Crivat, Brigitte Degeilh, Yves Hansmann, Claire Sauvage, Amandine Woerly, Benoit Jaulhac, Thierry Blanchon, Alice Raffetin, Julie Figoni, Jean Claude Desenclos, Henriette De Valk   +19 more
doaj   +1 more source

Engineering Rapid Payload Release Rate in 1,6‐Elimination Processes of Self‐Immolative Linkers

Angewandte Chemie, EarlyView.
The payload release rate of self‐immolative linkers was greatly improved through stabilization of an intermediate carbocation, thereby achieving an up to 10 000‐fold improvement in rate constant. Furthermore, lipophilicity was identified as another factor that affects the release rate. This new strategy is applicable to different payloads and different
Albert Marten Schulte, Gülbahar Bozan, Francesca Amoroso, Bart Cornelissen, Wiktor Szymanski   +4 more
wiley   +1 more source

Records of ticks (Acari: Ixodidae) on humans and distribution of spotted-fever cases and its tick vectors in Paraná State, southern Brazil

, 2020
Brazilian spotted fever (BSF) is the deadliest rickettsiosis in the world. Although the epidemiology of the disease has been established in Brazil, there are still limited data available on distribution of tick vectors and tick species parasitizing ...
Silva, Patrícia W., Arzua, Márcia, Silva, Aparecida M., Labruna, Marcelo B., Martins, Thiago F., Valente, Jessica D.M., Barros-Battesti, Darci M. [UNESP], Vieira, Rafael F.C., Vieira, Thállitha S.W.J.   +8 more
core   +1 more source

Duck Orbivirus and Egg Production: A Newly Identified Duck Orbivirus Is the Etiological Agent of Egg Production Decline in Chinese Breeder Ducks

Animal Research and One Health, EarlyView.
Field samples from breeder duck farms with egg‐production decline were subjected to viral detection, genome sequencing, and virus isolation. Experimental infection demonstrated that duck orbivirus (DORV) causes a significant and persistent reduction in egg production in breeder ducks.
Bing Li, Jianhua Wang, Xuezhi Cui, Xinxing Chu, You Wang, Dongmin Hao, Mingqing Xu, Haixia Chang, Huihui Li, Mingtian Mao, Mian Wu, Chengguang Lu, Jing Tang, Suyun Liang, Zhanbao Guo, Zhengkui Zhou, Youxiang Diao, Shuisheng Hou, Yi Tang   +18 more
wiley   +1 more source