Results 111 to 120 of about 19,735 (198)

Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy

Aggregate, Volume 7, Issue 6, June 2026.
Integrated engineering strategies combining oncolytic virus (OV) design with advanced delivery platforms overcome biological barriers and enhance cancer virotherapy. Genetic engineering improves viral potency and selectivity, while local and systemic delivery systems promote viral protection, tumor targeting, penetration, and tumor microenvironment ...
Jiliang Zhao, Dong Wang, Lei Wang, Hongkai Zhang, Yue Sun, Dan Ding   +5 more
wiley   +1 more source

Synergistic Antitumor Activity of HAT Inhibitor A485 and XPO1 Inhibitor KPT8602 in Multiple Myeloma

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Multiple myeloma (MM) remains the second most common hematologic malignancy, necessitating the identification of novel therapeutic targets. MM is characterized by a distinct epigenetic landscape driven by aberrant chromatin activation and super‐enhancer addiction.
Hong Xu, Wenqi Wu, Yanan Jiang, Jinhuan Wang, Yixin Zhai, Zhigang Zhao   +5 more
wiley   +1 more source

Super‐enhancer‐driven KIAA1522 upregulation suppresses ferroptosis in hepatocellular carcinoma

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Critical points: Aberrantly activated SEs drive the overexpression of the oncogene KIAA1522 in HCC. Targeting SEs and knocking down KIAA1522 facilitate ferroptosis in HCC. As a key downstream effector of KIAA1522, ATF4 plays an essential regulatory role in ferroptosis mediated by the oncoprotein. Abstract Background Aberrantly activated super‐enhancers
Xinyang Li, Siyuan Hu, Haolin Shi, Pan Bian, Ziming Wang, Jiachun Sun   +5 more
wiley   +1 more source

Spatial Epidemiology and Ecological Determinants of Ticks and Tick-Borne Pathogens Co-Circulation in Brijuni National Park, Croatia. [PDF]

Int J Environ Res Public Health
Cvek M, Pustijanac E, Vucelja M, Girotto D, Margaletić J, Bjedov L.   +5 more
europepmc   +1 more source

Individual characteristics, experience, and environmental conditions shape large‐scale patterns of animal activity timing

Ecosphere, Volume 17, Issue 6, June 2026.
Abstract The timing of an animal's activity affects its survival and reproduction because timing determines the nature of every interaction an organism has with its environment. Although the timing of activity may depend on aspects of the individual (e.g., body mass, reproductive status, experience) or the nature of the environment (e.g., temperature ...
Allison M. Brehm, Vania R. Assis, Lynn B. Martin, John L. Orrock   +3 more
wiley   +1 more source

Pathogen screening of Zambian ticks: new insights on the occurrence of tick-borne pathogens in the country. [PDF]

Parasit Vectors
Makayi C, Simainga S, Mertens-Scholz K, Chitimia-Dobler L, Fischer S, Labruna MB, Mans BJ, Dautu G, Brangsch H, Simuunza M, Groschup MH, Schulz A.   +11 more
europepmc   +1 more source

Landscape wetness and beaver wetlands enhance environmental prevalence of Francisella spp.

Ecosphere, Volume 17, Issue 6, June 2026.
Abstract Identifying the contributions of biotic and abiotic factors in pathogen transmission is essential to mitigate vector‐borne and zoonotic disease risk. Francisella tularensis is the etiological agent of the infectious disease tularemia in wildlife and humans. Environmental factors driving transmission in wildlife, including the role of hares and
Lovisa Hökby, Hussein Khalil, Helena Bylund, Mats Forsman, William Lidberg, Anita Norman, Ellinor Spörndly‐Nees, Anneli Ågren, Miriam Maas, Frauke Ecke   +9 more
wiley   +1 more source

Hydrogel Adhesives for Gastrointestinal Perforation: Design Principles and Applications

Exploration, Volume 6, Issue 3, June 2026.
There are few reviews on hydrogel adhesives that comprehensively highlight the design principles, factors affecting adhesion, and applications for gastrointestinal (GI) perforation repair. This review outlines the mainstream design approaches of hydrogel adhesives via covalent and noncovalent molecular interactions, illustrating the underlying adhesive
Yudi Pang, Shuai Tian, Qinyu Han, Yulin Deng, Jiatao Zhang, Enqiang Linghu, Qianqian Chen, Zhimin Wang   +7 more
wiley   +1 more source

Genetic diversity and co-circulation of tick-borne pathogens in Haemaphysalis spp. from Pakistan. [PDF]

Parasitol Res
Javed B, Numan M, Alam P, Haq HU, Ahmed H, Liaqat I, Almutairi MM, Aljasham AT, Ali A.   +8 more
europepmc   +1 more source

Light‐Activated Nucleic Acid Amplification Systems Using Photo‐Caged DNA Polymerase or Primers

Advanced Genetics, Volume 7, Issue 2, June 2026.
ABSTRACT Precise control over nucleic acid amplification is essential for achieving reliable, quantitative, high‐throughput, and multiplexed molecular diagnostics, particularly in point‐of‐care and field settings. However, conventional isothermal amplification methods, especially rapid assays at ambient temperature such as recombinase‐aided ...
Yang Wu, Meng Wu, Yukun Tian, Hao Chen, Xizhe Sun, Chukang Ma, Jiayao Liu, Fuyu Xia, Yu Liu, Xiaomeng Pei, Jing Wang, Guogang Zhao, Nan Wang, Fangfang Wang, Qing Liu, Fei Yu, Xiaofei Fan, Zehe Wang, Elena Ermilova, Jon S. West, Qi Cheng   +20 more
wiley   +1 more source