Results 121 to 130 of about 495,246 (243)

Tick-Borne Flaviviruses and the Type I Interferon Response

, 2018
Flaviviruses are globally distributed pathogens causing millions of human infections every year. Flaviviruses are arthropod-borne viruses and are mainly transmitted by either ticks or mosquitoes.
Lindqvist, Richard, Arunkumar Upadhyay, Överby, Anna K., Anna K. Överby, Anna Överby, Överby, Anna K.,, Upadhyay, Arunkumar S., Anna K. Överby, Upadhyay, Arunkumar S.,, Richard Lindqvist, Lindqvist, Richard,   +10 more
core   +1 more source

Ezh2 Inhibits the Differentiation of Short‐Lived Effector CD8+ T Cells and Promotes T Cell‐Dependent Antitumor Immunity

Cancer Science, EarlyView.
The antitumor immune response is attenuated in T cell‐specific Ezh2 knockout mice. ABSTRACT Appropriate regulation of the differentiation balance between effector CD8+ T cells and memory CD8+ T cells is crucial for an appropriate immune response. We previously reported that the tumor suppressor menin suppresses the differentiation of CD8+ T cells into ...
Kenji Takagi, Junpei Suzuki, Yuko Matsuoka, Makoto Kuwahara, Taro Oshikiri, Masakatsu Yamashita   +5 more
wiley   +1 more source

Mitochondrial Morphology Dynamics Remodel Metabolism and Affect TKI Sensitivity in EGFR‐Mutated Lung Cancer

Cancer Science, EarlyView.
TKI treatment promotes mitochondrial fission and metabolic reprogramming toward oxidative phosphorylation in residual EGFR‐mutant lung cancer cells. Targeting this metabolic vulnerability restores TKI sensitivity and provides a promising strategy to overcome acquired resistance.
Yu Zhao, Yuqiang Liu, Mingxuan Xie, Zhiming Ye, Hong Huang, Maojin Yao, Feng Zhou, Jianzhu Zhao, Jun Tang   +8 more
wiley   +1 more source

Tick-borne diseases in the North Sea region–A comprehensive overview and recommendations for diagnostics and treatment

As part of the NorthTick project, co-funded by the European Union through the European Regional Development Fund and the North Sea Region Programme, specialists in the field of tick-borne diseases from seven North Sea countries co-operated with patient ...
Lindgren, Per-Eric, Y. Kerlefsen, Lebech, Anne Mette, Dobler, Gerhard, Hovius, Joppe W.,, Fingerle, Volker,, Lernout, Tinne, Kerlefsen, Yvonne,, Vrijlandt, Amber, Mavin, Sally,, Henningsson, Anna J.,, L. Chin, Lim, Chin,, Kerlefsen, Yvonne, Lebech, Anne-Mette,, Lernout, Tinne,, A.M. Lebech, G. Dobler, H. Reiso, Henningsson, Anna J., Lindgren, Per Eric, Mavin, Sally, J.W. Hovius, Dobler, Gerhard,, Fingerle, Volker, S. Mavin, T. Lernout, Lim, Chin, Eikeland, Randi, Lindgren, Per-Eric,, Gynthersen, Rosa M.,, A. Vrijlandt, Lebech, Anne-Mette, Reiso, Harald, Eikeland, Randi,, P.E. Lindgren, Vrijlandt, Amber,, Gynthersen, Rosa M., R. Eikeland, Reiso, Harald,, R.M. Gynthersen, A.J. Henningsson, Hovius, Joppe W., F. Volker   +43 more
core   +1 more source

Structural insights into tyrosine sulfation of CCR5 by human tyrosylprotein sulfotransferase‐1

The FEBS Journal, EarlyView.
Structural analysis of human tyrosylprotein sulfotransferase‐1 (hTPST1) bound to a CCR5 N‐terminal peptide reveals how hTPST1 recognizes the Tyr3 sulfation site. Structure‐guided models of additional CCR5 sulfation states and full‐length assemblies provide a framework for understanding CCR5 tyrosine sulfation, a post‐translational modification relevant
Shinnosuke Tanaka, Hirai Asano, Kota Toyoda, Toshiaki Nishiyori, Hidetaka Kojo, Kazuto Kiyomatsu, Katsuhisa Kurogi, Yoichi Sakakibara, Etsuko Nishimoto, Takamasa Teramoto, Yoshimitsu Kakuta   +10 more
wiley   +1 more source

A scoping review of the acceptability, feasibility and effectiveness of opt‐out blood‐borne virus (BBV) testing in secondary healthcare settings, in the UK and similar settings, using APEASE criteria

HIV Medicine, EarlyView.
Abstract Background Earlier diagnosis of blood‐borne viruses (BBVs)—HIV, hepatitis B (HBV) and hepatitis C (HCV)—remains a significant public‐health focus. Opt‐out testing in secondary healthcare settings can improve early diagnosis and linkage to care as part of BBV transmission elimination targets.
Becky Metcalfe, Karen J. Maxwell, Kirsten Trayner, Max Wilkinson, Sharon Hutchinson, Claudia Estcourt, Alison J. Rodger   +6 more
wiley   +1 more source

Social Media Is a Threat for Democracy! A Political Perspective for Analysing and Diminishing Harm

Journal of Management Studies, EarlyView.
Abstract Social media platforms, once hailed as potential champions of dialogue, have evolved into commodified spaces in which their business models incentivize hate speech, misinformation, polarization, and the political fragmentation of society, benefiting corporate and political elites while eroding democracy.
Itziar Castelló, Elanor Colleoni, Andreas Georg Scherer, Hannah Trittin‐Ulbrich   +3 more
wiley   +1 more source

Generics favor stability

Mind &Language, EarlyView.
Humans seek to predict, explain, and control their environments. Generalizations—like those expressed by “children like candy” and “cigarettes cause cancer”—provide one resource to facilitate these tasks. We develop a proposal tying the acceptability judgments of generics to the psychological functions of generalizations.
Katherine Ritchie, Ny Vasil
wiley   +1 more source

Come together: Data sharing to support one health responses to vector‐borne disease threats

Medical and Veterinary Entomology, EarlyView.
A One Health framework integrating diverse data across human, animal and environmental sectors is essential for effective surveillance and response is vital for responding to vector‐borne disease risks. Communities adopting global data standards, depositing data in shared repositories, and responsible data use can significantly improve VBD data ...
Francis Windram, Sarah Kelly, Stanislav Modrak, Isabelle Dietrich, Corrado Minetti, Karen L. Mansfield, Frederik Seelig, Adam M. Fisher, Maisie Vollans, Nina Billows, Fahad Ahmed, Marta Shocket, Susana Campino, Scott Tytheridge, Sara L. Gandy, Estela Gonzalez, Jolyon M. Medlock, Matthew Baylis, Grant L. Hughes, David A. Ewing, Bethan V. Purse, Georgia Kirby, Clare Strode, Arran J. Folly, David Starns, Heather Ferguson, Simon Smith‐Mullally, Helen Roberts, Christopher M. Jones, Hannah Rose Vineer, Marion England, Christopher Sanders, Samraat Pawar, William D. Pearse, Steven M. White, Robert T. Jones, Lauren J. Cator   +36 more
wiley   +1 more source

Virus‐Mediated Self‐Assembly of Functional Cyclodextrins for Antiviral Inhibition

Angewandte Chemie, Volume 138, Issue 38, 14 September 2026.
A sialic acid (SA)‐functionalized cyclodextrin (CD) self‐assembles on SARS‐CoV‐2 through ligand–receptor recognition, nucleating cooperative supramolecular polymer growth that blocks infection. The adaptive assembly requires both ligand binding and host–guest polymerization, remains active across variants, and can be tuned by coassembly, establishing ...
Pedro J. Hernando, Laora Boulo, Léonid Lavnevich, Elisa Teyssou, Stéphane Marot, Adélie Gothland, Jean‐Michel Guigner, Anne‐Geneviève Marcelin, Mickaël Ménand, Vincent Calvez, Matthieu Sollogoub   +10 more
wiley   +2 more sources