Results 241 to 250 of about 469,795 (310)

Geometrically Encoded Positioning of Introns, Intergenic Segments, and Exons in the Human Genome

open access: yesAdvanced Science, EarlyView.
This study introduces a new hypothesis: exons, introns, and intergenic segments are non‐random projections of the functional layers of 3D structure of chromatin packing domains. Evidence is presented that this “geometric code” may encode volumetric structure, reconciling epigenetic patterns, correlates with oncogenic mutations, acting as a potential ...
Luay M. Almassalha   +11 more
wiley   +1 more source

Blood plasma proteomics for detecting potential biomarkers for tick resistance in a tropically adapted beef cattle breed. [PDF]

open access: yesBMC Genomics
Abduch NG   +7 more
europepmc   +1 more source

EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non‐Small Cell Lung Cancer via Hippo Pathway Activation

open access: yesAdvanced Science, EarlyView.
EM2 directly binds to and activates MST1/2, enhancing their kinase activity and sequentially promoting LATS phosphorylation, which increases YAP phosphorylation. Consequently, YAP nuclear translocation is suppressed, leading to reduced transcription of downstream targets CTGF and CYR61, ultimately exerting a robust inhibitory effect on NSCLC cell ...
Siyu Yang   +15 more
wiley   +1 more source

Tick-borne protozoa in dogs: Combined diagnostic approaches reveal unnoticed carriers of Hepatozoon canis and Theileria orientalis among owned dogs in Northen Italy

open access: hybrid
Filippo Maria Dini   +6 more
openalex   +1 more source

Universal Regulation of DNA Polymerase via Photocaged Primer Enables Light‐Start Isothermal Amplification on Demand

open access: yesAdvanced Science, EarlyView.
A simple and general photoactivatable approach is developed to regulate DNA polymerase activity, enabling light‐start isothermal amplification on demand. The molecular dynamics simulations reveals that the photocaged primer blocks DNA polymerase activity by inhibiting the conformational change of the polymerase.
Min Qing   +7 more
wiley   +1 more source

Neoehrlichia mikurensis in Ticks and Tick-Bitten Persons, Sweden and Finland, 2008-2009. [PDF]

open access: yesEmerg Infect Dis
Hero E   +5 more
europepmc   +1 more source

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