Results 151 to 160 of about 9,864,889 (296)

Tickborne diseases of the United States : a reference manual for health care providers [PDF]

"228690-A."Based on "Tickborne Diseases in Massachusetts: A Physician's Reference Manual" 2nd ed. [Boston, MA] : Massachusetts Department of Public Health, Division of Epidemiology and Immunization, 2009.On back cover: For more information please contact

core  

A New Recruitable E3 Ligase UHRF1 Supporting Targeted Protein Degradation: A Minimal Azide as a Recruitment Ligand

Advanced Science, EarlyView.
Targeted protein degradation is often limited by the scarcity of usable E3 ligases. Herein, we report the first small‐molecule GPX4 degraders that incorporate either electrophilic warheads or a minimal azide group as an E3 recruitment ligand. The azide‐based degrader DK‐5070 effectively drives potent GPX4 degradation; mechanistic studies reveal that ...
Zehong Lin, Kang Duan, Rui Wan, Tao Jiang, Jinzhe Wei, Miao Sun, Mariia A. Skryl'nikova, Maxim A. Gureev, Zhi‐Min Zhang, Zhang Zhang, Ke Ding, Nan Ma, Tongzheng Liu, Yi Tan, Zhengqiu Li   +14 more
wiley   +1 more source

SynNotch Receptors for Visualizing Immunoreceptor Force Transmission and Downstream Signaling In Vivo

Advanced Science, EarlyView.
A mechanically activated SynNotch reporter platform enables detection of force transmission through receptors as they mediate immune cell interactions. Targeting CD40 on B cells and TCR on T cells records force‐induced reporter activation across 2D coculture, 3D organoid, and implanted in mice, which also reveal force‐amplification of immune receptor ...
Menglan Li, Jintian Lyu, Kaitao Li, Ameya Dravid, Deepali Balasubramani, Amir H. K. Ashkezari, Hyun‐Kyu Choi, Gabriel A. Kwong, Ankur Singh, Cheng Zhu   +9 more
wiley   +1 more source

Innovative granular formulation of Metarhizium robertsii microsclerotia and blastospores for cattle tick control. [PDF]

Sci Rep, 2021
Marciano AF, Mascarin GM, Franco RFF, Golo PS, Jaronski ST, Fernandes ÉKK, Bittencourt VREP.   +6 more
europepmc   +1 more source

Targeting the PHB2–ACSL3 Lipid‐Remodeling Axis Overcomes Cisplatin Resistance by Restoring Ferroptosis in Gastric Cancer

Advanced Science, EarlyView.
ABSTRACT Platinum‐based chemotherapy resistance remains a major obstacle in gastric cancer (GC) treatment. Through integrated transcriptomic profiling of cisplatin‐resistant xenografts and pharmacogenomic interrogation of the NCI‐60 dataset, we identified Prohibitin‐2 (PHB2) as a previously unrecognized determinant of chemoresistance.
Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang, Zhipu Zhu, Man Tong, Lei Jin, Yan Ye   +10 more
wiley   +1 more source

An exploratory study on tick control in the field. [PDF]

Curr Res Parasitol Vector Borne Dis
Wang YD, Liu SS, Yang YC, Du J.
europepmc   +1 more source

Effects of Tick-Control Interventions on Tick Abundance, Human Encounters with Ticks, and Incidence of Tickborne Diseases in Residential Neighborhoods, New York, USA. [PDF]

Emerg Infect Dis, 2022
Keesing F, Mowry S, Bremer W, Duerr S, Evans AS, Fischhoff IR, Hinckley AF, Hook SA, Keating F, Pendleton J, Pfister A, Teator M, Ostfeld RS.   +12 more
europepmc   +1 more source

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

Acaricide resistance in <i>Amblyomma cajennense</i> s.l. and implications for integrated tick control in Ecuadorian cattle systems. [PDF]

Front Vet Sci
Pérez-Otáñez X, Vanwambeke SO, Paucar-Quishpe V, Pérez C, Grijalva-Olmedo J, Cepeda-Bastidas D, Orozco G, Enríquez Morillo S, Saegerman C, Ron-Garrido L, Rodríguez-Hidalgo R.   +10 more
europepmc   +1 more source

Spatial Heterogeneity of Sympatric Tick Species and Tick-Borne Pathogens Emphasizes the Need for Surveillance for Effective Tick Control. [PDF]

Vector Borne Zoonotic Dis, 2021
Machtinger ET, Nadolny RM, Vinyard BT, Eisen L, Hojgaard A, Haynes SA, Bowman L, Casal C, Li AY.   +8 more
europepmc   +1 more source