Results 211 to 220 of about 77,020 (267)

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

Advanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang, Peipei Song, Xueji Wu, Lei Wang, Wei Xie, Pinning Feng, Chao Cheng, Jianping Guo   +7 more
wiley   +1 more source

Ecological Variation in Species Composition and Attachment Preferences of Ixodid Ticks Infesting <i>Bos taurus</i> in the Eastern Cape Province, South Africa. [PDF]

Microorganisms
Zuko M, Nkululeko N, Mandla Y, Mhlangabezi S, Ishmael J.   +4 more
europepmc   +1 more source

Mastication‐Induced Electrical Stimulation Activates Prg4+ Chondroprogenitors for Osteoarthritis Therapy

Advanced Science, EarlyView.
This study presents a ″trash‐to‐treasure″ strategy that converts harmful joint overloads into beneficial electrical cues. The biodegradable MagPie, by providing piezoelectrical stimulation and releasing Mg2+ during mastication, exerts synergistic pro‐regenerative and anti‐inflammatory effects on Prg4+ cells via the ECM‐mediated FAK‐PI3K‐Akt axis ...
Shi‐Yang Feng, Jing‐Rong Cheng, Yu Qin, Jie Lei, Chen‐Chen Gao, Hong‐Ying Fu, Li‐Ping Wu, Thanh D. Nguyen, Xu‐Liang Deng, Kai‐Yuan Fu, Yang Liu   +10 more
wiley   +1 more source

Investigation of Tick Species and Seasonal Population Dynamics in Sheep, Cattle, and Goats in Ağrı Province, Türkiye. [PDF]

Pathogens
Yilmaz AB, Afsar M, Yasul M, Selcuk MA, Torkamanian-Afshar M, Ozbek A, Yilmaz H.   +6 more
europepmc   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Langat Virus Infection Can Be Demonstrated in Both Tick Salivary Glands and Midgut Within 24 Hours of Blood Feeding. [PDF]

Viruses
Ochwoto M, Offerdahl DK, Ogola EO, Weck BC, Long D, Saturday GA, Bloom ME.   +6 more
europepmc   +1 more source

NFYB Integrates Hormonal Signals into Tissue Allometry by Promoting Protein Biosynthesis

Advanced Science, EarlyView.
In the American cockroach, NFYB acts as a spatiotemporin that translates distinct hormonal cues into tissue‐specific allometry. Juvenile hormone activates NFYB in the early fat body, while 20‐hydroxyecdysone induces it in late wing pads. NFYB then promotes protein biosynthesis via core translational machinery, driving differential growth across the ...
Fangfang Liu, Shiming Zhu, Sishi Xia, Xiaoshuai Zhang, Qin Li, Zhanquan Zeng, Yuqing Liu, Wanyin Liang, Guanyu Zhou, Erxia Du, Suning Liu, Sheng Li   +11 more
wiley   +1 more source

Accelerating Progress on Ticks and Tick-Borne Diseases in Southeast Asia: Regional Challenges, Evidence Gaps, and Priorities (2023-2025). [PDF]

Pathogens
Malleret B, Kwak ML, Chavatte JM.
europepmc   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Tailored D‐π Conjugation Boosts Piezocatalytic CO2 Reduction in a Platinum(II)‐Acetylide Framework

Advanced Science, EarlyView.
The highly conjugated metalII‐acetylide framework demonstrates efficient ultrasound‐driven conversion of CO2 to CO. The piezoelectric field generated by ultrasound facilitates electron transfer from the tetraphenylene π‐column to the MII‐bis(acetylide) moiety, enabling CO2 activation. Compared to PdII‐ and NiII‐based analogues, the stronger d–π orbital
Mude Zhu, Yingtang Zhou, Kai Wang, Xiaoyun Fan, Yang Ding, Wai‐Yeung Wong, Linli Xu   +6 more
wiley   +1 more source