Results 41 to 50 of about 50,763 (266)

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Cloning, and Molecular Characterization of Polymorphic Iranian Isolate Theileria annulata Surface Protein (Tasp)

Iranian Journal of Parasitology, 2012
Background: Because of the strong immunologic responses of surface protein TaSp in Theileria annu­lata infected host, we tried to characterize this protein in a T. annulata isolate from Iran. Methods: The RNA prepared from T. annulata infected cells was
N Sadr-Shirazi, P Shayan, B Eckert, E Ebrahimzadeh, N Amininia   +4 more
doaj  

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Isolation of Small Number of Cryptosporidium parvum Oocyst Using Immunochromatography

Iranian Journal of Parasitology, 2014
Background: Cryptosporidium parvum causes severe gastroenteritis in immunocompromised human and new borne animals. The organism can be transmitted through water. Since small number of C. parvum is infectious, the aim of the present study was to develop a
Elahe Ebrahimzade, Parviz Shayan, Zeinab Asghari, Sedighe Jafari, Zahra Omidian   +4 more
doaj  

A novel combination of fipronil and permethrin (Frontline Tri-Act®/Frontect®) reduces risk of transmission of Babesia canis by Dermacentor reticulatus and of Ehrlichia canis by Rhipicephalus sanguineus ticks to dogs

Parasites & Vectors, 2015
Background The ability of Frontline Tri-Act®/Frontect®, a topical ectoparasiticide containing fipronil and permethrin for dogs, to prevent the transmission of Babesia canis as well as Ehrlichia canis was evaluated by infesting dogs with infected vector ...
Frans Jongejan, Christa de Vos, Josephus J. Fourie, Frederic Beugnet   +3 more
doaj   +1 more source

Epidemiological aspects of bovine trypanosomosis in an endemic focus of eastern Zambia: The role of trypanosome strain variability in disease pattern

Onderstepoort Journal of Veterinary Research, 2012
Bovine trypanosomosis displays various epidemiological aspects in various areas. In some instances the disease has a high prevalence in animals with high impact on production whereas in other cases the disease has a low impact on production despite a ...
Justin Masumu, G. Tshilenge, V. Mbao
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Molecular detection of Anaplasma phagocytophilum in carrier cattle of Iran - first documented report

Iranian Journal of Microbiology, 2009
Background and Objectives: Anaplasma phagocytophilum is a zoonotic, tick borne rickettsial pathogen. A. phagocytophilum has been detected in North America, Europe, Africa and Asia by molecular methods.
V Noaman, P Shayan
doaj  

Comparative microbiomes of ticks collected from a black rhino and its surrounding environment

International Journal for Parasitology: Parasites and Wildlife, 2019
‘Eliska,’ an endangered black rhino (Diceros bicornis), died suddenly in Mkomazi National Park in Tanzania in 2016. Three Amblyomma gemma ticks were collected from Eliska's body, and four ticks were collected from the surrounding field.
Seogwon Lee, Ju Yeong Kim, Myung-hee Yi, In-Yong Lee, Robert Fyumagwa, Tai-Soon Yong   +5 more
doaj   +1 more source

Determination of Fauna of Hard Ticks on Sheep in Khuzestan Province, Iran

مجله دانشکده پزشکی اصفهان, 2020
Background: Khuzestan Province is one of the most important provinces of Iran in the field of livestock breeding. On the other hand, the infection of sheep with ticks that are important carriers of human and animal pathogens is significant. Ticks can act
Alireza Farahani, Mohammad Hossein Razi-Jalali, Hossein Hamidi-Nejat, Mohammad Reza Tabandeh   +3 more
doaj   +1 more source