Results 61 to 70 of about 62,552 (337)

Parallel Genome‐Wide CRISPR Screens Reveal SORL1 and ZFYVE19 as Sequential Host Determinants of Salmonella Infection

Advanced Science, EarlyView.
To distinguish how Salmonella invades cells vs how it survives long‐term, a parallel CRISPR screening platform is developed. This approach reveals the host proteins that the bacterium exploits at different stages of infection. The study identifies SORL1 as a novel host factor for invasion and demonstrates that blocking it with an antibody effectively ...
Sehee Yun, Seoyeon Kim, Seonggyu Kim, Minsoo Noh, Dae‐Kyum Kim, Eun‐Jin Lee, Hunsang Lee   +6 more
wiley   +1 more source

F‐Box and Leucine‐Rich Repeat Protein 4 (FBXL4) Maintains Sarcomere Integrity and Cardiac Function by Enhancing K48‐Linked Ubiquitinated Degradation of Profilin‐1 (PFN1)

Advanced Science, EarlyView.
Schematic diagram depicting the proposed signaling mechanisms underlying the effects of FBXL4 in the setting of cardiac hypertrophy. Under hypertrophic stimulation, cardiomyocytes‐specific overexpression FBXL4 maintains sarcomere integrity and cardiac function by enhancing K48‐linked ubiquitinated degradation of PFN1 at the K70 site.
Xingda Li, Xueqi He, Xinyuan Hao, Yu Zhang, Xin Zhao, Shuang Wang, Zhenru Wang, Haonan Du, Hongda Li, Lian Yi, Zhimin Du, Weijie Du   +11 more
wiley   +1 more source

Enhanced tidal disruption rates from massive black hole binaries

, 2009
"Hard" massive black hole (MBH) binaries embedded in steep stellar cusps can shrink via three-body slingshot interactions. We show that this process will inevitably be accompanied by a burst of stellar tidal disruptions, at a rate that can be several ...
Alberto Sesana, Baker, Blecha, Brown, Chen, Donley, F. K. Liu, Haehnelt, Hairer, Hills, Komossa, Levin, Lippai, Liu, Madau, Milosavljević, Perets, Piero Madau, Sesana, Sesana, Sesana, Sesana, Sesana, Shields, Volonteri, Volonteri, Wang, Wyithe, Xian Chen, Yu   +29 more
core   +1 more source

Tidal scattering of stars on supermassive black holes in galactic centers [PDF]

, 2001
Some of the mass that feeds the growth of a massive black hole (BH) in a galactic center is supplied by tidal disruption of stars that approach it on unbound, low angular momentum orbits.
Frank J., Frank J., Genzel R., Komossa S., Komossa S., Mario Livio, Tal Alexander, Ulmer A.   +7 more
core   +2 more sources

A Unified Model for Tidal Disruption Events [PDF]

The Astrophysical Journal Letters, 2018
Abstract In the past few years wide-field optical and UV transient surveys and X-ray telescopes have allowed us to identify a few dozen candidate tidal disruption events (TDEs). While in theory the physical processes in TDEs are ubiquitous, a few distinct classes of TDEs have been observed.
Lixin Dai, Jonathan C. McKinney, Nathaniel Roth, Enrico Ramirez-Ruiz, M. Coleman Miller   +4 more
openaire   +3 more sources

Biomimetic Multiscale‐Structured Biomass Graphene/Polyurethane Sponge Composite for Flexible Pressure Sensors and Intelligent Cushioning Materials

Advanced Science, EarlyView.
In this study, a multifunctional conductive sponge composite (MAPU) is developed using a biomimetic, hierarchical construction strategy emulating the growth process of natural wood. This approach involved integrating biomass‐derived graphitic nanoflakes, synthesized from luffa vine (LVGN), into a polyurethane (PU) sponge matrix.
Runmin Xu, Pusen Cao, Tingting Zhang, Jie Wei, Yue Wang, Zhi Huang, Zhenghang Chen, Jianfeng Xi, Yong Guo, Yuxia Chen   +9 more
wiley   +1 more source

The Double Tidal Disruption Event AT 2022dbl Implies that at Least Some “Standard” Optical Tidal Disruption Events Are Partial Disruptions

The Astrophysical Journal Letters
Flares produced following the tidal disruption of stars by supermassive black holes can reveal the properties of the otherwise dormant majority of black holes and the physics of accretion.
Lydia Makrygianni, Iair Arcavi, Megan Newsome, Ananya Bandopadhyay, Eric R. Coughlin, Itai Linial, Brenna Mockler, Eliot Quataert, Chris Nixon, Benjamin Godson, Miika Pursiainen, Giorgos Leloudas, K. Decker French, Adi Zitrin, Sara Faris, Marco C. Lam, Assaf Horesh, Itai Sfaradi, Michael Fausnaugh, Ehud Nakar, Kendall Ackley, Moira Andrews, Panos Charalampopoulos, Benjamin D. R. Davies, Yael Dgany, Martin J. Dyer, Joseph Farah, Rob Fender, David A. Green, D. Andrew Howell, Thomas Killestein, Niilo Koivisto, Joseph Lyman, Curtis McCully, Morgan A. Mitchell, Estefania Padilla Gonzalez, Lauren Rhodes, Anwesha Sahu, Giacomo Terreran, Ben Warwick   +39 more
doaj   +1 more source

Fundamental scaling relationships revealed in the optical light curves of tidal disruption events [PDF]

, 2023
Andrew Mummery, Sjoert van Velzen, Edward Nathan, Adam Ingram, Erica Hammerstein, Ludovic Fraser-Taliente, Steven A. Balbus   +6 more
openalex   +1 more source

Weighing Black Holes Using Tidal Disruption Events [PDF]

The Astrophysical Journal, 2019
Abstract While once rare, observations of stars being tidally disrupted by supermassive black holes are quickly becoming commonplace. To continue to learn from these events, it is necessary to robustly and systematically compare our growing number of observations with theory.
Brenna Mockler, James Guillochon, Enrico Ramirez-Ruiz   +2 more
openaire   +3 more sources

Remote Activation of Spinal TRPV1 by Magnetic Nanocubes Confers Cardioprotection Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
Fe‐based magnetic nanocubes conjugated with TRPV1 antibodies (FeNCs‐TRPV1) are developed for the specific targeting of TRPV1 channels. Intraspinally injected FeNCs‐TRPV1 induces TRPV1 desensitization in rats exposed to repetitive and transient ACMF.
Xueying Cheng, Shuangyu Liu, Yu Zhang, Kang Peng, Muge Qile, Chao Wu, Mengyun Dou, Liu Liu, Na Yang, Rui Liu, Guiyang Zhang, Liangping Ni, Gaolin Liang, Fang Yang, Ye Zhang, Shufang He   +15 more
wiley   +1 more source