Results 91 to 100 of about 264,615 (344)

Best PEEP trials are dependent on tidal volume [PDF]

Critical Care, 2018
Determining the optimal positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome remains an area of active investigation. Most trials individualizing PEEP optimize one physiologic parameter (e.g., driving pressure) by titrating PEEP while holding other ventilator settings constant.
Todd W. Rice, Andrew C. McKown, Matthew W. Semler   +2 more
openaire   +4 more sources

Stability, chaos and entrapment of stars in very wide pairs

, 2011
The relative motion of stars and other celestial objects in very wide pairs, separated by distances of the order of 1 pc, is strongly influenced by the tidal gravitational potential of the Galaxy.
Anosova, Astakhov, Beech, Beech, Bertolami, Caballero, Chambers, Fukushige, Hayes, Hayes, Hénon, Jiang, King, Kouwenhoven, Makarov, Makarov, Makarov, Milgrom, Shaya, Valeri V. Makarov, Wertheimer   +20 more
core   +1 more source

Activation of Lysosomal Retrograde Transport Triggers TPC1‐IP3R1 Ca2+ Crosstalk at Lysosome‐ER MCSs Leading to Lethal Depleting of ER Calcium

Advanced Science, EarlyView.
The flavonoid compound LW‐213 exerts its antitumor effects through a novel mechanism involving lysosomal‐ER calcium regulation. Specifically, LW‐213 binds to LIMP2, which induces perinuclear clustering of lysosomes and facilitates calcium‐mediated lysosome‐ER interactions.
Meng‐yuan Zhu, Yong‐jian Guo, Yu‐qi Zhu, Hong‐zheng Wang, Hai‐di Wang, Hong‐yu Chen, Yue‐xin Jiang, Hui Li, Hui Hui   +8 more
wiley   +1 more source

A systematic numerical study of the tidal instability in a rotating triaxial ellipsoid [PDF]

, 2010
The full non-linear evolution of the tidal instability is studied numerically in an ellipsoidal fluid domain relevant for planetary cores applications.
Aldridge, Bayly, Benton, Boubnov, Chan, Craik, D. Cébron, Eloy, Eloy, Gledzer, Gledzer, Gledzer, Greenspan, Haj-Hariri, Herreman, Hollerbach, Hough, J. Leontini, Kelvin, Kerswell, Kerswell, Kerswell, Lacaze, Lacaze, Lacaze, Lacaze, Lainey, Le Bars, Le Bars, Le Dizès, Le Dizès, Leblanc, Leblanc, Leweke, Leweke, Lundgren, M. Le Bars, Malkus, Mason, McAlister, Meunier, Moore, Munk, P. Le Gal, P. Maubert, Pierrehumbert, Poincaré, Potylitsin, Rieutord, Roy, Seyed-Mahmoud, Seyed-Mahmoud, Shangli, Sipp, Sipp, Thess, Touma, Vladimirov, Waleffe, Widnall, Williams   +60 more
core   +4 more sources

Comprehensive Characterization of the Immune Microenvironment Based on Nested Resampling Machine Learning Framework Identifies TRAF3 Interacting Protein 3 as a Promising Regulator to Improve the Resistance to Immunotherapy in Glioma

Advanced Science, EarlyView.
This study develops a nested resampling machine learning framework to establish the Immune Glioma Survival Signature (IGLoS), which stratifies glioma patients and predicts immunotherapy resistance. Multi‐omics analyses reveal TRAF3IP3 as a pivotal regulator of PD‐L1 expression and T‐cell exhaustion via ERK‐NFATC2 signaling.
Yanbo Yang, Fei Wang, Yulian Zhang, Run Huang, Chuanpeng Zhang, Lu Zhao, Hanhan Dang, Xinyu Tao, Yue Lu, Dengfeng Lu, Yunsheng Zhang, Kun He, Jiancong Weng, Zhouqing Chen, Zhong Wang, Yanbing Yu   +15 more
wiley   +1 more source

Numerical study of variable lung ventilation strategies

, 2015
Mechanical ventilation is used for patients with a variety of lung diseases. Traditionally, ventilators have been designed to monotonously deliver equal sized breaths.
Bagler, Ganesh, Ghatge, Mayur, Hiremath, Kirankumar, Yadav, Reena   +3 more
core   +1 more source

Lateral Marsh Edge Erosion as a Source of Sediments for Vertical Marsh Accretion [PDF]

, 2018
With sea level rise accelerating and sediment inputs to the coast declining worldwide, there is concern that tidal wetlands will drown. To better understand this concern, sources of sediment contributing to marsh elevation gain were computed for Plum ...
Barbier, Bauer, Blum, Blum, Cahoon, Cavatorta, Claessens, Cook, Costanza, Day, Day, Dhillon, Donnelly, Donnelly, Engelhart, Eyre, Fagherazzi, Fagherazzi, Foley, Forbrich, French, Ganju, Ganju, Geyer, Gittman, Gosselink, Hayden, Hein, Hobbs, Hopkinson, Hughes, Kirwan, Kirwan, Kirwan, Koch, Lane, Leonardi, Leonardi, Leonardi, Levin, Magirl, Marcus, Mariotti, Mariotti, Mariotti, Mattheus, McGeehin, McKee, Meade, Meade, Megonigal, Millette, Milliman, Mineau, Morris, Morris, Morris, Morris, Morris, Mudd, Pasternack, Pavich, Priestas, Rahmstorf, Raymond, Redfield, Redfield, Redfield, Reed, Rovere, Schmidt, Schwimmer, Sholkovitz, Stuiver, Swales, Syvitski, Townsend, Trimble, Vallino, Vallino, Walsh, Warrick, Warrick, Watson, Weston, Wilson, Wollheim, Wollheim, Worm, Yarbro, Zhao   +90 more
core   +3 more sources

Cellular Adaptation to Mechanical Stress Emerges via Cell Shrinkage Triggered by Nonlinear Calcium Elevation

Advanced Science, EarlyView.
Here, a decision‐making mechanism underlying mechanical adaptation is demonstrated. This study demonstrates that cellular adaptation to mechanical stress can be induced by applying low‐amplitude stretch to cells. When the stretch reaches a critical amplitude threshold, it triggers Ca2⁺‐dependent positive feedback, which induces cholesterol efflux and ...
Zhengyan Wang, Zihan Li, Lei Wang, Haitao Zhang, Xiaoshan Yang, Lili Bao, Geng Dou, Lili Ren, Yajing Fu, Lan Li, Shengkai Gong, Yang Zhou, Feng Ding, Lu Yu, Haotian Luo, Yao Liu, Fuyang Zhang, Hui Yu, Siying Liu, Xueming Liu, Fulan Wei, Shiyu Liu   +21 more
wiley   +1 more source

Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis

Advanced Science, EarlyView.
The study in this paper found that activating the α2A receptors of astrocytes in the thoracic spinal cord can reduce the release of inflammatory factors, thereby decreasing the necroptosis of GABAergic neurons and consequently alleviating myocardial injury caused by sepsis.
Ruilin He, Bin Wu, Liuhu Han, Mingde Li, Wenli Guo, Jiajing Fu, Bin Mei, Eric R. Gross, Xuesheng Liu, Yao Lu   +9 more
wiley   +1 more source

Kinematically Detected Halo Streams

, 2016
Clues to the origins and evolution of our Galaxy can be found in the kinematics of stars around us. Remnants of accreted satellite galaxies produce over- densities in velocity-space, which can remain coherent for much longer than spatial over-densities ...
Smith, Martin C.
core   +1 more source