Results 41 to 50 of about 71,185 (259)
Journal of Thoracic Disease, 2019 Prior to publication of the ARDSNet trial of tidal volumes (VT) (1), traditional mechanical ventilation often employed VT of 10–15 mL/kg of unadjusted body weight. While these volumes had long been noted to exceed those of healthy subjects [who usually breathe at 6–8 mL/kg of predicted body weight (PBW)], they were considered necessary for intubated ...
David J, Dries, John J, Marini
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Advanced Science, EarlyView.PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu +17 more
wiley +1 more source
Alveolar Overdistension as a Cause of Lung Injury: Differences among Three Animal Species
The Scientific World Journal, 2012 This study analyses characteristics of lung injuries produced by alveolar overdistension in three animal species. Mechanical ventilation at normal tidal volume (10 mL/Kg) and high tidal volume (50 mL/Kg) was applied for 30 min in each species.
Manuel García-Delgado +5 more
doaj +1 more source
Advanced Science, EarlyView.The uncovered IKKβ‐USP28‐HEY1 axis fuels cancer stemness and immune evasion in hepatocellular carcinoma. USP28 deubiquitinates HEY1 upon IKKβ‐mediated phosphorylation, conferring PD‐1/PD‐L1 blockade resistance. Pharmacological inhibition of USP28 sensitizes resistant tumors to anti‐PD‐1 immunotherapy, revealing a promising therapeutic strategy ...
Na Shao +8 more
wiley +1 more source
Advanced Science, EarlyView.P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang +8 more
wiley +1 more source
Nudging implementation of low tidal volume ventilation: a stepped wedge, cluster randomized trial
Implementation ScienceBackground “Nudges” embedded in the electronic health record (EHR) facilitate desired decisions while preserving autonomy and may provide a scalable strategy to overcome the common implementation barrier of lack of knowledge about a best practice.
Meeta Prasad Kerlin +18 more
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BMC Anesthesiology, 2014 Background Recent evidence suggests that the use of low tidal volume ventilation with the application of positive end-expiratory pressure (PEEP) may benefit patients at risk of respiratory complications during general anaesthesia.
Dharshi Karalapillai +14 more
doaj +1 more source
Critical Care, 2023 Background Pulse pressure variation (PPV) has been widely used in hemodynamic assessment. Nevertheless, PPV is limited in low tidal volume ventilation. We conducted this systematic review and meta-analysis to evaluate whether the tidal volume challenge ...
Xiaoying Wang +4 more
doaj +1 more source
Frontiers in Physiology, 2021 Background: Inspiratory loading is experienced by military divers when they use rebreather device. Our objective was to assess the changes in diaphragm function induced by an increase in inspiratory load at values similar to those experienced by divers ...
Sarah Rives +7 more
doaj +1 more source
Advanced Science, EarlyView.Treatment‐resistant wounds caused by polymicrobial biofilms are refractory to conventional therapies due to the dense extracellular matrices. We developed μBLAST, a microblasting wound dressing that combines MnO2‐doped biosilica and a H2O2‐releasing mesh to generate localized oxygen microbubbles that mechanically disrupt biofilms.
Yujin Ahn +12 more
wiley +1 more source